Research Journal of Pharmacy and Technology

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Formulation and In vitro Evaluation of Matrix Tablets containing Pioglitazone


Affiliations
1 B.L.D.E.A’s SSM College of Pharmacy and Research Centre, Vijayapura,-586103, India
2 S.J.M College of Pharmacy, S J M Campus, Chitradurga,-577502, India
     

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The objective of the study was to develop matrix tablet of Pioglitazone. Tablets of Pioglitazone were prepared by the wet granulation method using polymers like Hydroxy propyl methylcellulose, Sodium CMC, Methyl cellulose, Ethyl cellulose in different ratios. Matrix tablet were evaluated by different methods for parameters such as thickness, hardness, weight uniformity, drug content uniformity, and in vitro drug release studies, stability studies. The tablets were evaluated for in vitro release in pH7.4 phosphate buffer for 12 hours in standard dissolution apparatus. Mucoadhesion strength is increased with increase in the concentration of HPMC. In order to determine the mode of release, the data was subjected to Zero order, First order, Higuchi and Peppas diffusion model. Short term stability studies on the promising formulation indicated that, there are no significant changes in drug content. IR spectroscopic indicated that there are no drug- excipients interaction. All the granules of the formulation showed in compliance with Pharmacopeial Standards. The developed sustain released matrix tablet of Pioglitazone drug showed 12 hours of drug release and overcome the disadvantage of conventional tablets.

Keywords

Matrix Tablet: Pioglitazone, HPMC, Sodium CMC, Methyl Cellulose, Ethyl Cellulose.
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  • Lachman L, Lieberman A, Kanig J. The theory and practice of Industrial Pharmacy. Mumbai: Varghese publishing house 1990; 3: 430-431.

  • Tripathi KD. Essentials of Medical Pharmacology. New Delhi: Jaypee Brothers, Medical publishers (P) LTD 2003; 5: 235-249.

  • Koichiro T. Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methyl cellulose 2910. J Cntrl Rel 1995; 35:59-66.

  • Shalin A. ModI, P. D. Gaikwad, V. H. Bankar, S. P. Pawar, Sustained Release Drug Delivery System: A Review 2011, IJPRD/2011/PUB/ARTI/VOV-2/ISSUE-12/FEB/016.

  • Srivastav M, Prabhakar B. Omray A, 2011 “Extended Release Tablet Technologies –Matrix, Melt Granulation and Multi Particulates: An Overview”, Int.J of Uni Pharm And Life Sci.

  • Vicky D. Ranpura, Atul Kathiriya, Ketan V. Shah. Formulation, Development and Characterization Of Sustained Release Bilayered Tablet Of Valsartan And Pioglitazone Hcl. Vol - 4, Issue - 3, Apr-Jul 2013.

  • Prasanth Sai. R.V et al. Formulation, Evaluation and Characterization Of Sustained-Release Matrix Tablets Of Timolol Maleate Using Hydrophilic, Hydrophobic And Plastic Polymers. IJPT 3(2) , 2011,2807-2847.

  • Kamlesh J. Wadher.et al. Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers. Bri J of Pharmaceutical Research 1(2): 29-45, 2011

  • Mantada et al. Formulation and In-Vitro Evaluation Of Sustained Release Matrix Tablets of Pioglitazone Hydrochloride. IJDFR 2(4),2011.

  • Jorapur P, Reddy V, vijapure VK, Biradar S. Formulation and evaluation of Gastroretentive microspheres of Cefpodoxime proxetil, Research J. Pharm. and Tech. 10(6): June 2017.

  • Patidar et al. Formulation and Evaluation of Pioglitazone Hydrochloride Matrix Tablet Containing Aloe Barbadensis Miller Mucilage Natural Antidiabetic Agent. International Journal of Drug Discovery and herbal research (IJDDHR) 1(3).2011, 157163.

  • Sekharan R.T., Palanichamy S., Shanmuganathan S., Tamilvanan S 2009 “Formulation and evaluation of theophylline controlled release matrix tablets using Guar gum” ARS Pharmaceutical vol 50 n°4: 205-214.

  • V Pandit et al. Preparation and Characterization of Pioglitazone Cyclodextrin Inclusion Complexes. J Young Pharm. 3(4): 2011.267–274.

  • Patil CC, Patel B, Vijapure VK, formulation and evaluation of transdermal drug delivery system of ramipril. Research J. Pharm. and Tech. 9(12): 2016.

  • Nayak RK, Manjunath B, Swamy VBN, Senthil A, Thakkar HK, Kumar DM, Mahalaxmi R. Design and Evaluation of sustained release floating tablets of Loratadine. Asian J. Pharm. Res. 2011; 3(1): 105-124.


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  • Formulation and In vitro Evaluation of Matrix Tablets containing Pioglitazone

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Authors

C. C. Patil
B.L.D.E.A’s SSM College of Pharmacy and Research Centre, Vijayapura,-586103, India
Shedyal Bhairappa
S.J.M College of Pharmacy, S J M Campus, Chitradurga,-577502, India
K. Vijapure Vitthal
S.J.M College of Pharmacy, S J M Campus, Chitradurga,-577502, India

Abstract


The objective of the study was to develop matrix tablet of Pioglitazone. Tablets of Pioglitazone were prepared by the wet granulation method using polymers like Hydroxy propyl methylcellulose, Sodium CMC, Methyl cellulose, Ethyl cellulose in different ratios. Matrix tablet were evaluated by different methods for parameters such as thickness, hardness, weight uniformity, drug content uniformity, and in vitro drug release studies, stability studies. The tablets were evaluated for in vitro release in pH7.4 phosphate buffer for 12 hours in standard dissolution apparatus. Mucoadhesion strength is increased with increase in the concentration of HPMC. In order to determine the mode of release, the data was subjected to Zero order, First order, Higuchi and Peppas diffusion model. Short term stability studies on the promising formulation indicated that, there are no significant changes in drug content. IR spectroscopic indicated that there are no drug- excipients interaction. All the granules of the formulation showed in compliance with Pharmacopeial Standards. The developed sustain released matrix tablet of Pioglitazone drug showed 12 hours of drug release and overcome the disadvantage of conventional tablets.

Keywords


Matrix Tablet: Pioglitazone, HPMC, Sodium CMC, Methyl Cellulose, Ethyl Cellulose.

References