Formulation and In vitro Evaluation of Matrix Tablets containing Pioglitazone

The objective of the study was to develop matrix tablet of Pioglitazone. Tablets of Pioglitazone were prepared by the wet granulation method using polymers like Hydroxy propyl methylcellulose, Sodium CMC, Methyl cellulose, Ethyl cellulose in different ratios. Matrix tablet were evaluated by different methods for parameters such as thickness, hardness, weight uniformity, drug content uniformity, and in vitro drug release studies, stability studies. The tablets were evaluated for in vitro release in pH7.4 phosphate buffer for 12 hours in standard dissolution apparatus. Mucoadhesion strength is increased with increase in the concentration of HPMC. In order to determine the mode of release, the data was subjected to Zero order, First order, Higuchi and Peppas diffusion model. Short term stability studies on the promising formulation indicated that, there are no significant changes in drug content. IR spectroscopic indicated that there are no drug- excipients interaction. All the granules of the formulation showed in compliance with Pharmacopeial Standards. The developed sustain released matrix tablet of Pioglitazone drug showed 12 hours of drug release and overcome the disadvantage of conventional tablets.