Research Journal of Pharmacy and Technology

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Formulation and Evaluation of Immediate Release Tablets of Topiramate using Sodium Starch Glycolate


Affiliations
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, India
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, India
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, India
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, India
     

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The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.

Keywords

IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.
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  • Formulation and Evaluation of Immediate Release Tablets of Topiramate using Sodium Starch Glycolate

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Authors

Kanhu Charan Panda
Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, India
Niranjan Panda
Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, India
Chinmaya Keshari Sahoo
Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, India
Jimidi Bhaskar
Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, India
D. Venkata Ramana
Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, India

Abstract


The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.

Keywords


IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.

References