Open Access
Subscription Access
Open Access
Subscription Access
Formulation and Evaluation of Immediate Release Tablets of Topiramate using Sodium Starch Glycolate
Subscribe/Renew Journal
The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.
Keywords
IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.
Subscription
Login to verify subscription
User
Font Size
Information
- Lachman L, liberman HA, Kanig JL. The theory and practice of industrial pharmacy. Tablets, Edition 3, 1990: 293-335.
- Srinivas P. Preparation and in vitro Evaluation of Nizatidine immediate release tablets. International Journal of Pharm Tech Research, 3(3), 2011, 1688-1692.
- Chetan NY, Sagar SD, Amit G, Ganga S. Formulation and Evaluation of Immediate Release Tablet of Paroxetine Hydrochloride. Journal of Pharmacy Research 3(8), 2010, 1736-1738.
- 4.Sahoo CK, Venkata Ramana D, Sahoo NK, Panda KC, Panigrahy UP. Formulation and Evaluation of Immediate release Tablets of Dasatinib using Croscarmelose Sodium, Research J. Pharm. and Tech. 10(3), 2017, 833-838.
- Patel N, Naruka PS, Chauhan CS, Modi J. Formulation Development and Evaluation of Immediate Release Tablet of Topiramateanti Epileptic Drug. JPSBR 3(2),2013, 58-65.
- Sahoo CK, Mohanty D, Bhaskar J, Ramana DV. Formulation and Evaluation of Fast Dissolving Tablets of Carvedilol using Sodium Starch Glycolate. Int. J. Pharm. Sci. Rev. Res., 51(1), 2018, 35-40.
- Ahmed JA. A Review on fast dissolving tablet dosage form. Int. J. of Pharmacy and Pharmaceutical Research. 2 (3),2015,1-17.
- Sahoo CK, Sahoo NK, Sahu M, Moharana AK, Sarangi DK. Formulation and Evaluation of Orodispersible Tablets of Granisetron Hydrochloride Using Agar as Natural Super disintegrants. Pharm Methods 7(1),2016, 17-22.
- Srinivas P, Mahalaxmi R. Preparation and invitro evaluation of nizatidine fast dissolving tablets. Int. J. Pharmtech Res.3 (3); 2011: 1688-1692.
- Sahoo CK, Sahoo TK, Moharana AK. Designing of orodispersible tablet of diethyl carbamazine citrate for the treatment of filariasis, Inter J Appl Biol Pharm Tech. 2,2011,70-74.
- Sahoo CK, Sahoo NK, Sahu M, Alagarsamy V, Moharana AK, Sarangi DK, Satyanarayana K.Formulation and evaluation of orodispersible tablets of granisetron hydrochloride using platago ovate as natural superdisintigrants, Indonesian J. Pharm. 27(1), 2016, 35-43.
- Tiwari AK, Shah A, Rajpoot A, Manmohan Singhal. Formulation and In-vitro Evaluation of Fast dissolving tablets of Drotaverine HCl. J. Chem. Pharm. Res. 3(4); 2011:333-341
- Rai VK, Pathak N, Bhaskar R, Nandi BC, Dey S, Tyagi LK. Optimization of fast dissolving tablet of Raloxifene hydrochloride by wet granulation method. Int J Pharm Sci and drug Res. 1(1),2009,51-54.
- Sahoo CK, Sudhakar M, Bhanja S, Panigrahy UP, Panda KC. Development and evaluation of immediate release tablets of dasatinib using sodium starch glycolate as super disintegrants, Innoriginal International Journal of Sciences 4(1), 2017, 1-4.
- ICH harmonized tripartite guideline, Stability testing of new drug substance and product.Q1A (R2). Federal Register 2003; 68:65717-18.
Abstract Views: 357
PDF Views: 0