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Repurposing Drugs for Management of Alzheimer Disease


Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, Ooty, Tamilnadu-643001, India
2 Affiliated by JSS Academy of Higher Education and Research, Mysuru, Karnataka, India
     

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Alzheimer's disease (AD), or Alzheimer’s, It is neurodegenerative disease starts very slowly and with time it got worse one of the biggest challenge of the CNS drug delivery scientist. Mental and physic exercise, Cholinesterase Inhibitors, and avoiding adipositas may reduce the risk of the AD. Currently, existing/approved drugs for the treatment of the AD are based on neurotransmitter or enzyme replacement/modulation. Existing therapies gives just an optimum advantage and consequently, in present, there is an evident desire for advanced medications or therapies. Drug repurposing is one of the latest trend and the alternative approach in drug advancement, with a history of successful reuse of currently available drugs. A signify category of the drugs reuse in the management of the AD among them the prominent category is the anticancer, antiepileptic, antibiotics, ant diabetic etc. The review focuses on mechanism and application for the repurposing of the existing drugs in the light of the clinical and pre-clinical evidences.

Keywords

Alzheimer’s Disease, Repurposing Drugs, Repurposed Drugs Pathways, Preclinical Data, Clinical Evidences.
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  • Repurposing Drugs for Management of Alzheimer Disease

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Authors

Senthil Venkatachalam
Department of Pharmaceutics, JSS College of Pharmacy, Ooty, Tamilnadu-643001, India
Ayush Jaiswal
Department of Pharmaceutics, JSS College of Pharmacy, Ooty, Tamilnadu-643001, India
Anindita De
Affiliated by JSS Academy of Higher Education and Research, Mysuru, Karnataka, India
Rohith Krishnan Vijayakumar
Affiliated by JSS Academy of Higher Education and Research, Mysuru, Karnataka, India

Abstract


Alzheimer's disease (AD), or Alzheimer’s, It is neurodegenerative disease starts very slowly and with time it got worse one of the biggest challenge of the CNS drug delivery scientist. Mental and physic exercise, Cholinesterase Inhibitors, and avoiding adipositas may reduce the risk of the AD. Currently, existing/approved drugs for the treatment of the AD are based on neurotransmitter or enzyme replacement/modulation. Existing therapies gives just an optimum advantage and consequently, in present, there is an evident desire for advanced medications or therapies. Drug repurposing is one of the latest trend and the alternative approach in drug advancement, with a history of successful reuse of currently available drugs. A signify category of the drugs reuse in the management of the AD among them the prominent category is the anticancer, antiepileptic, antibiotics, ant diabetic etc. The review focuses on mechanism and application for the repurposing of the existing drugs in the light of the clinical and pre-clinical evidences.

Keywords


Alzheimer’s Disease, Repurposing Drugs, Repurposed Drugs Pathways, Preclinical Data, Clinical Evidences.

References