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Nigella sativa:Phytochemistry, Pharmacology and its Therapeutic Potential


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1 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, India
     

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Nigella sativa belonging to family ranunculaceae. This plant is an extensively used as medicinal plant in India as well as all over the world. Nigella sativa (N. sativa) is well known plant of traditional systems of medicine such as Ayurveda, Siddha and Unani. It is also known as nutmeg flower, black seed, black cumin, black caraway, fennel flower, roman coriander, and kalonji. Alkaloids, phenols, flavonoids, glycosides, terpenoids and steroids are the important phyto constituents of N. sativa. The active constituents of N. sativa are thymohydroquinone, p-cymene, dithymoquinone, thymoquinone, carvacrol, sesquiterpene longifolene. N. sativa seed also contains pentacyclic triterpene, alpha-hederin, protein, carbohydrates, crude fibre, fat and saponin. N. sativa oil contains oleic acid, palmitic acid, linoleic acid. Aromatics contain α-thujene, thymol, α-pinene, thymoquinone, dihydrothymoquinone. N. sativa has been used as stimulant, emmenagogue, appetizer, pungent, anthelmintic, pungent, deodorant, carminative, purgative, expectorant, febrifuge, deodorant etc. N. sativa possess numerous pharmacological action such as antibacterial, antifungal, anticancer, hepatoprotective, antioxidant, antiinflammatory, analgesic, immunomodulatory, antidiabetic, dyslipidemia, antiepileptic, gastroprotective, antioxytocic, anti-fertility, respiratory, dermatological, nephroprotective, antiviral, testicular-protective, antidepressant and anticonvulsant activity. So considering the medicinal value and its therapeutic potential this review article would spotlight on phytochemistry, chemical composition and pharmacological activity of N. sativa.

Keywords

Nigella sativa, Phytochemistry, Black Seed, Nutmeg Flower, Pharmacological Activity.
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  • Samajdar S. Extraction and chemical tests on Nigella Sativa l. collected from Punjab region of India. Pharma Tutor. 2017; 5 (12): 54-57.

  • Ramadan MF. Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. International journal of food science & technology. 2007; 42(10): 1208-1218.

  • Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine. 2013; 3(5): 337-352.

  • Darakhshan S, Pour AB, Colagar AH, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. Pharmacological research. 2015; 95: 138-158.

  • Alamgir AN. Pharmacognostical Botany: Classification of medicinal and aromatic plants (MAPs), botanical taxonomy, morphology, and anatomy of drug plants. In Therapeutic Use of Medicinal Plants and Their Extracts: Volume 1 2017: 177-293.

  • Forouzanfar F, Bazzaz BS, Hosseinzadeh H. Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects. Iranian journal of basic medical sciences. 2014; 17(12): 929.

  • Al-Jassir MS. Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia. Food Chem. 1992; 45: 239-242.

  • Atta-Ur-Rahman Nigellidine-a new indazole alkaloid from the seed of Nigella sativa. Tetrahedron Lett. 1995; 36(12): 1993-1994.

  • Nickavar B, Mojab F, Javidnia K, Amoli MA. Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch C. 2003; 58(9–10):629–631.

  • Cheikh-Rouhou S, Besbes S, Lognay G, Blecker C, Deroanne C, Attia H. Sterol composition of black cumin (Nigella sativa L.) and Aleppo pine (Pinus halpensis Mill.) seed oils. J Food Comp Anal. 2008; 21(2):162-168.

  • Bourgou S, Ksouri R, Bellila A, Skandrani I, Falleh H, Marzouk B. Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and ischolar_mains. C R Biol. 2008; 331(1): 48-55.

  • Nickavar B, Mojab F, Javidnia K, Amoli MA. Chemic al composition of the fixed and volatile oils of Nigella sativa L. from Iran. Z Naturforsch C. 2003; 58(9)10: 629-631.

  • Morikawa T, Xu F, Ninomiya K, Matsuda H, Yoshikawa M. N. mines A3, A4, A5 and C, new dolabellane-type diterpene alkaloids with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. Chem Pharm Bull. 2004; 52(4): 494-497.

  • Morikawa T, Xu F, Kashima Y, Matsuda H, Ninomiya K, Oshikawa M. Noveldolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Org Lett. 2004; 6(6): 869-872.

  • Ali Z, Ferreira D, Carvalho P, Avery MA, Khan IA. Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa. J Nat Prod. 2008; 71(6): 1111-1112.

  • Mehta BK, Pandit V, Gupta M. New principles from seeds of Nigella sativa. Nat Prod Res. 2009; 23(2): 138-48.

  • Yarnell E, Abascal K. Nigella sativa: holy herb of the middle East. Altern Compl Therap. 2011; 17(2): 99-105.

  • Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity-the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008; 6: 495-510.

  • Bakathir HA, Abbas NA. Detection of the antibacterial effect of nigella sativa ground seeds with water. African Journal of Traditional, Complementary and Alternative Medicines. 2011; 8(2): 159-164.

  • Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation. BMC complementary and alternative medicine. 2011; 11(1): 29.

  • Hannan A, Saleem S, Chaudhary S, Barkaat M, Arshad MU. Anti-bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. J Ayub Med Coll Abbottabad. 2008; 20(3): 72-74.

  • Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, et al. et al. Comparative study of Nigella sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol. 2010; 16(3): 207-214.

  • Aljabre SH, Alakloby OM, Randhawa MA. Dermatological effects of Nigella sativa. Journal of Dermatology & Dermatologic Surgery. 2015; 19(2): 92-98.

  • Yousefi M, Barikbin B, Kamalinejad M, Abolhasani E, Ebadi A, Younespour S, Manouchehrian M, Hejazi S. Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema. Journal of the European Academy of Dermatology and Venereology. 2013; 27(12): 1498-1504.

  • Ghorbanibirgani A, Khalili A, Rokhafrooz D. Comparing Nigella sativa oil and fish oil in treatment of vitiligo. Iranian Red Crescent Medical Journal. 2014; 16(6): 4515.

  • Halamova K, Kokoska L, Flesar J, Sklenickova O, Svobodova B, Marsik P. In vitro antifungal effect of black cumin seed quinones against dairy spoilage yeasts at different acidity levels. J Food Prot. 2010; 73(12):2291-2295.

  • Salem ML, Alenzi FQ, Attia WY. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro. British journal of biomedical science. 2011; 68(3): 131-137.

  • Mahmoud SS, Torchilin VP. Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. Cell biochemistry and biophysics. 2013; 66(3): 451-460.

  • Hagag AA, Elaal AM, Elsheik A, Elzamarany EA. Protective effect of Nigella Sativa oil against methotrexate induced hepatotoxicity in children with acute lymphoblastic leukemia. Journal of Leukemia. 2013; 20: 1-8.

  • Abdel-Hamid NM, Abdel-Ghany MI, Nazmy MH, Amgad SW. Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?. Environmental health and preventive medicine. 2013; 18(1): 49.

  • Mariod AA, Ibrahim RM, Ismail M, Ismail N. Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake. Food Chem. 2009; 116(1): 306-312.

  • Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem Biol Interact. 2012; 197(1):40-46.

  • Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. J Diabetes. 2010; 2(4):256-266.

  • Altan MF, Kanter M, Donmez S, Kartal ME, Buyukbas S. Combination therapy Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats. Acta Histochem. 2007; 109(4): 304-314.

  • Alemi M, Sabouni F, Sanjarian F, Haghbeen K, Ansari S. Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content. AAPS PharmSci Tech. 2013; 14(1):160-167.

  • Majdalawieh AF, Hmaidan R, Carr RI. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol. 2010, 131(2): 268-275.

  • Ghonime M, Eldomany R, Abdelaziz A, Soliman H. Evaluation of immunomodulatory effect of three herbal plants growing in Egypt. Immunopharmacol Immunotoxicol. 2011; 33(1):141-145.

  • Assayed ME. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Immunopharmacol Immunotoxicol. 2010, 32(2): 284-296.

  • Moeen-Ud-Din HA, Murad SH, Fatima AJ. Placebo controlled study on comparison of effects of Nigella sativa and nicotinic acid along with low fat diet and physical exercise on LDL-cholesterol and HDL-cholesterol. Pak J Med Health Sci. 2014; 8(2): 306-309.

  • Sahebkar A, Beccuti G, Simental-Mendia LE, Nobili V, Bo S. Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacological research. 2016; 106: 37-50.

  • Tasawar Z, Siraj Z, Ahmad N, Lashari MH. The effects of Nigella sativa (Kalonji) on lipid profile in patients with stable coronary artery disease in Multan, Pakistan. Pak J Nutr. 2011; 10(2): 162-167.

  • Ibrahim RM, Hamdan NS, Mahmud R, Imam MU, Saini SM, Rashid SN, Ghafar SA, Ab Latiff L, Ismail M. A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women. Journal of translational medicine. 2014; 12(1): 82.

  • Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR, Soukhtanloo M. Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chinese journal of integrative medicine. 2015; 21(6): 438-444.

  • Islam MH, Ahmad IZ, Salman MT. Neuroprotective effects of Nigella sativa extracts during germination on central nervous system. Pharmacognosy magazine. 2015; 11(1): 182.

  • El-Dakhakhny M, Barakat M, El-Halim MA, Aly SM. Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. Journal of ethnopharmacology. 2000; 72(1-2): 299-304.

  • Islam MT, Guha B, Hosen S, Riaz TA, Shahadat S. Nigellalogy: A Review on Nigella sativa. MOJ Bioequiv Availab. 2017; 3(6): 00056.

  • Aqel M, Shaheen R. Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharm. 1996; 52(1): 23-26.

  • Ijaz H, Tulain UR, Qureshi J, Danish Z, Musayab S, Akhtar MF, Saleem A, Khan KA, Zaman M, Waheed I, Khan I. Nigella sativa (Prophetic Medicine): A Review. Pakistan journal of pharmaceutical sciences. 2017; 30(1): 229-234.

  • Maghsoudi H, Haj-allahyari S. Anti-inflammatory Effect of Alcoholic Extract of Nigella sativa L on Bovine Fibroblast-like synoviocyte and THP-1. International Journal of Contemporary Research and Review. 2018; 9(02): 20181-20191.

  • Boskabady MH, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010; 17(10): 707-713.

  • Oysu C, Tosun A, Yilmaz HB, Sahin-Yilmaz A, Korkmaz D, Karaaslan A. Topical Nigella sativa for nasal symptoms in elderly. Auris Nasus Larynx. 2014; 41(3): 269-272.

  • Oladejo BO, Obameso JO, Anibijuwon II. Evaluation of Lemon and Black Seed Oils on Bacteria Isolated from HIV Positive Patients. Asian Journal of Biological Sciences. 2018; 11: 108-113.

  • Onifade AA, Jewell AP, Adedeji WA. Nigella sativa concoction induced sustained seroreversion in HIV patient. African Journal of Traditional, Complementary and Alternative Medicines. 2013; 10(5): 332-335.

  • Aljabre SH, Alakloby OM, Randhawa MA. Dermatological effects of Nigella sativa. Journal of Dermatology & Dermatologic Surgery. 2015; 19(2):92-98.

  • Ali SA, Meitei KV. Nigella sativa seed extract and its bioactive compound thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores. Journal of Pharmacy and Pharmacology. 2011; 63(5): 741-746.

  • Yousefi M, Barikbin B, Kamalinejad M, Abolhasani E, Ebadi A, Younespour S, Manouchehrian M, Hejazi S. Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema. Journal of the European Academy of Dermatology and Venereology. 2013; 27(12): 1498-1504.

  • Saleem U, Ahmad B, Rehman K, Mahmood S, Alam M, Erum A. Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits. Pak J Pharm Sci. 2012; 25(4): 727-730.

  • Abul-Nasr SM, El-Shafey MDM, Osfor MMH. Amelioration by Nigella sativa of methotrexate induced toxicity in male albino rats: a biochemical, haematological and histological study. Scintia Agri Bohemica. 2001; 32: 123-160.

  • Yildiz F, Coban S, Terzi A, Savas M, Bitiren M, Celik H, et al. et al. Protective effects of Nigella sativaagainst ischemia-reperfusion injury of kidneys. Ren Fail. 2010; 32(1): 126-131.

  • Gokce A, Oktar S, Koc A, Yonden Z. Protective effects of thymoquinone against methotrexate-induced testicular injury. Hum Exp Toxicol. 2011; 30(8): 897-903.

  • Al-Naggar TB, Gomez-Serranillos MP, Carretero ME, Villar AM. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003; 88(1): 63-68.

  • Perveen T, Abdullah A, Haider S, Sonia B, Munawar AS, Haleem DJ. Long-term administration of Nigella sativa effects nociceotion and improves learning and memory in rats. Pak J Biochem Mol Biol. 2008; 41(3): 141-143.

  • Noor NA, Aboul Ezz HS, Faraag AR, Khadrawy YA. Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. Epilepsy Behav. 2012; 24(2): 199-206.

  • Majumdar M, Samanta A, Roy A. Study of wound healing activity of different formulations of Nigella sativa seed extract. Research J. Pharm. and Tech. 2016; 9(12): 2097.


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  • Nigella sativa:Phytochemistry, Pharmacology and its Therapeutic Potential

Abstract Views: 473  |  PDF Views: 1

Authors

Prashant Tiwari
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, India
Susmita Jena
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, India
Swaroop Satpathy
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, India
Pratap Kumar Sahu
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar-751029, India

Abstract


Nigella sativa belonging to family ranunculaceae. This plant is an extensively used as medicinal plant in India as well as all over the world. Nigella sativa (N. sativa) is well known plant of traditional systems of medicine such as Ayurveda, Siddha and Unani. It is also known as nutmeg flower, black seed, black cumin, black caraway, fennel flower, roman coriander, and kalonji. Alkaloids, phenols, flavonoids, glycosides, terpenoids and steroids are the important phyto constituents of N. sativa. The active constituents of N. sativa are thymohydroquinone, p-cymene, dithymoquinone, thymoquinone, carvacrol, sesquiterpene longifolene. N. sativa seed also contains pentacyclic triterpene, alpha-hederin, protein, carbohydrates, crude fibre, fat and saponin. N. sativa oil contains oleic acid, palmitic acid, linoleic acid. Aromatics contain α-thujene, thymol, α-pinene, thymoquinone, dihydrothymoquinone. N. sativa has been used as stimulant, emmenagogue, appetizer, pungent, anthelmintic, pungent, deodorant, carminative, purgative, expectorant, febrifuge, deodorant etc. N. sativa possess numerous pharmacological action such as antibacterial, antifungal, anticancer, hepatoprotective, antioxidant, antiinflammatory, analgesic, immunomodulatory, antidiabetic, dyslipidemia, antiepileptic, gastroprotective, antioxytocic, anti-fertility, respiratory, dermatological, nephroprotective, antiviral, testicular-protective, antidepressant and anticonvulsant activity. So considering the medicinal value and its therapeutic potential this review article would spotlight on phytochemistry, chemical composition and pharmacological activity of N. sativa.

Keywords


Nigella sativa, Phytochemistry, Black Seed, Nutmeg Flower, Pharmacological Activity.

References