Research Journal of Pharmacy and Technology

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Novel Approaches in Nanoparticulate Drug Delivery System to Overcome Human Immunodeficiency Virus


Affiliations
1 Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore, Karnataka-560035, India
     

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The development of antiretroviral medication has considerably modified the perception of Human Immunodeficiency virus /Acquired immunodeficiency syndrome (HIV/AIDS) as a fatal to a last stage manageable sickness. The convenience and organization of antiretroviral medicinal consideration has essentially diminished mortality and horribleness related to HIV and AIDS. Antiretroviral drug deficiency remains a serious drawback in underserved populations worldwide. Partnerships among pharmaceutical corporations, tutorial investigators and government and nongovernment agencies is necessary to boost access to life-saving regimens. Nanomedicine opens new restorative roads for assaulting viral diseases and for enhancing treatment achievement rates. Significantly, nanomaterials like dendrimers and numerous other inorganic nanoparticles like gold, silver, zinc, and iron can be utilized for HIV treatment. Moreover, nanoparticles could best go about as adjuvants, convoys throughout vaccine delivery, nanomedicine could also be an appropriate methodology in HIV/AIDS treatment by methods for offering lower dose and aspect impact, better patient-to-persistent consistency and HIV diagnosis. This article explores the varied applicable methods for delivery of antiretroviral drugs within the style of liposomes, dendrimers, solid lipid nanoparticles, microspheres and polymeric nanoparticles. These approaches of delivery are verified to supply innovative and direct delivery of antiretroviral medication by enhancing the therapeutic effectiveness, targeting the location of action and increasing the activity and safety of the medication.

Keywords

Antiretroviral Drug, Drug Delivery, HIV, Nanocarriers, Nanomedicine.
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  • Farokhzad OC. Nanotechnology for drug delivery: the perfect partnership. Expert opinion on drug delivery. 2008;5(9):927-9.

  • Jana U, Pal S, Mohanta GP, Manna PK, Manavalan R. Nanoparticles: A Potential Approach for Drug Delivery. Research Journal of Pharmacy and Technology. 2011;4(7):1016-9.

  • Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, Andrian UV, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine. 2010;5(2):269-85.

  • Singhal G, Bhavesh R, Kasariya K, Sharma AR, Singh RP. Biosynthesis of silver nanoparticles using Ocimum sanctum (Tulsi) leaf extract and screening its antimicrobial activity. Journal of Nanoparticle Research. 2011;13(7):2981-8.

  • Nachega JB, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Research and Human Retroviruses. 2004;20(10):1053-6.

  • Maheshwari P, Sunny M. A Prospective Study on the Knowledge, Attitude and Perception on HIV/AIDS among the Nursing and other Healthcare Professionals. Research Journal of Pharmacy and Technology. 2016;9(9):1403.

  • Velmurugan S, ALIa MA, Kumar P. Microparticulate drug carriers: A promising approach for the delivery of anti-HIV drugs. Int J. Pharm. Pharm Sci. 2014;6(2):31-9.

  • Corsi F, Sorrentino L, Mazzucchelli S, Truffi M, Capetti A, Rizzardini G, Fiandra L. Antiretroviral therapy through barriers: a prominent role for nanotechnology in HIV-1 eradication from sanctuaries. Journal of Pharmacy and Pharmacology. 2016;2016(4):328-40.

  • Lembo D, Cavalli R. Nanoparticulate delivery systems for antiviral drugs. Antiviral Chemistry and Chemotherapy. 2010;21(2):53-70.

  • Kumar P, Jacob J, Ajina K. Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug. Research Journal of Pharmacy and Technology. 2016 May 1;9(5):538.

  • Saravanan M, Asmalash T, Gebrekidan A, Gebreegziabiher D, Araya T, Hilekiros H, Barabadi H, Ramanathan K. Nano-Medicine as a Newly Emerging Approach to Combat Human Immunodeficiency Virus (HIV). Pharmaceutical nanotechnology. 2018;6(1):17-27.

  • Bala R, Madaan R, Arora S. Green Synthesis and Characterization of silver nanoparticles using Kinnowmandarian peels extract and its application in Shampoo Formulation. Research Journal of Pharmacy and Technology. 2017;10(8):2461-6.

  • Heger Z, Cernei N, Adam V, Kizek R. Nanomedicine in the future of HIV treatment.

  • Panda S, Pattnaik S, Maharana L, Teja CK. HIV and AIDS: Need of an Effective Drug Delivery. Research Journal of Pharmacy and Technology. 2014;7(6):686.

  • Murthy B, Vishakha K, Prakash P. Formulation and in vitro evaluation of liposomes loaded with mupirocin. International Journal of Research in Pharmaceutical and Nano Sciences. 2018;4(3):162-174.

  • Srikanth K, Nappinnai M, Gupta VR. Proniosomes: A novel drug carrier system. Research Journal of Pharmacy and Technology. 2010;3(3).

  • Begum MY, Shaik MR, Abbulu K, Sudhakar M. Ketorolac Tromethamine Loaded Liposomes: Development, Characterization and In Vitro Evaluation. Research Journal of Pharmacy and Technology. 2011;4(11):1766-71.

  • Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K. Liposome: classification, preparation, and applications. Nanoscale research letters. 2013;8(1):102.

  • Maurya SD, Prajapati S, Gupta A, Saxena G, Dhakar RC. Formulation development and evaluation of ethosome of stavudine. Int J Pharm Edu Res. 2010; 13:16.

  • Pai R, Devi KV. Lamivudine liposomes for transdermal delivery- formulation, characterization, stability and in vitro evaluation. Int J Pharm Sci Nanotechnol. 2009; 1:317-26.

  • James ND, Coker RJ, Tomlinson D, Harris JR, Gompels M, Pinching AJ, Stewart JS. Liposomal doxorubicin (Doxil): an effective new treatment for Kaposi's sarcoma in AIDS. Clinical oncology. 1994;6(5):294-6.

  • Kaur CD, Nahar M, Jain NK. Lymphatic targeting of zidovudine using surface-engineered liposomes. Journal of drug targeting. 2008;16(10):798-805.

  • Ahammed V, Narayan R, Paul J, Nayak Y, Roy B, Shavi GV, Nayak UY. Development and in vivo evaluation of functionalized ritonavir proliposomes for lymphatic targeting. Life sciences. 2017; 183:11-20.

  • Avti PK, Kakkar A. Dendrimers as anti-inflammatory agents. Brazilian Journal of Pharmaceutical Sciences. 2013;49(SPE):57-65.

  • Kumar PD, Kumar PV, Saravanan G. Strategies in Dendritic architecture for drug delivery-An over review. Indian Journal of Research in Pharmacy and Biotechnology. 2013;1(6):922.

  • Kumar S. in-vitro and in-vivo Evaluation of Poly (Propyl Ether Imine) (PETIM) Dendrimer for Sustained Delivery of Zidovudine. Journal of Antivirals and Antiretrovirals. 2013;05(06).

  • Dutta T, Garg M, Jain NK. Targeting of efavirenz loaded tuftsin conjugated poly (propyleneimine) dendrimers to HIV infected macrophages in vitro. European journal of pharmaceutical sciences. 2008;34(2-3):181-9.

  • Dutta T, Jain NK. Targeting potential and anti-HIV activity of lamivudine loaded mannosylated poly (propyleneimine) dendrimer. Biochimica et Biophysica Acta (BBA)-General Subjects. 2007;1770(4):681-6.

  • Prabhakar C, Krishna KB. A Review on Polymeric Nanoparticles. Research Journal of Pharmacy and Technology. 2011;4(4):496-8.

  • Parboosing R, Maguire GE, Govender P, Kruger HG. Nanotechnology and the treatment of HIV infection. Viruses. 2012;4(4):488-520.

  • Mapari S, Patil P. Nanoparticles for the treatment of HIV fungal infections. Int J Pharm Bio Sci 2015; 6(1): (P) 149 – 169.

  • Leyva-Gómez G, Pinon-Segundo E, Mendoza-Muñoz N, Zambrano-Zaragoza ML, Mendoza-Elvira S, Quintanar-Guerrero D. Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art. International journal of molecular sciences. 2018;19(6):1549.

  • Shah LK, Amiji MM. Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS. Pharmaceutical research. 2006;23(11):2638-45.

  • Rashmi C, J Adlin Jino Nesalin, Tamizh Mani T. Preparation and evaluation of Nevirapine nanoparticle. International Journal of Research in Pharmacy and Pharmaceutical Sciences.2017;2(3):41-46.

  • Hari BV, Narayanan N, Dhevedaran K. Efavirenz–eudragit E-100 nanoparticle-loaded aerosol foam for sustained release: in-vitro and ex-vivo evaluation. Chemical Papers. 2015;69(2):358-67.

  • das Neves J, Araújo F, Andrade F, Michiels J, Ariën KK, Vanham G, Amiji M, Bahia MF, Sarmento B. In vitro and ex vivo evaluation of polymeric nanoparticles for vaginal and rectal delivery of the anti-HIV drug dapivirine. Molecular pharmaceutics. 2013;10(7):2793-807.

  • Singh G, Pai RS. Atazanavir-loaded Eudragit RL 100 nanoparticles to improve oral bioavailability: optimization and in vitro/in vivo appraisal. Drug delivery. 2016;23(2):532-9.

  • Mukherjee S, Ray S, Thakur RS. Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian journal of pharmaceutical sciences. 2009;71(4):349.

  • Ram DT, Debnath S, Babu MN, Nath TC, Thejeswi B. A review on solid lipid nanoparticles. Research Journal of Pharmacy and Technology. 2012;5(11):2.

  • Garud A, Singh D, Garud N. Solid lipid nanoparticles (SLN): method, characterization and applications. International Current Pharmaceutical Journal. 2012;1(11):384-93.

  • Alukda D, Sturgis T, Youan BB. Formulation of tenofovir‐loaded functionalized solid lipid nanoparticles intended for HIV prevention. Journal of pharmaceutical sciences. 2011;100(8):3345-56.

  • Shah R, Eldridge D, Palombo E, Harding I. Optimisation and Stability Assessment of Solid Lipid Nanoparticles using Particle Size and Zeta Potential. Journal of Physical Science. 2014;25(1).

  • Javan F, Vatanara A, Azadmanesh K, Nabi‐Meibodi M, Shakouri M. Encapsulation of ritonavir in solid lipid nanoparticles: in‐vitro anti‐HIV‐1 activity using lentiviral particles. Journal of Pharmacy and Pharmacology. 2017;69(8):1002-9.

  • Shegokar R, Singh KK. Preparation characterization and cell-based delivery of stavudine surface modified lipid nanoparticles. J Nanomed Biotherapeut Discov. 2012;2(3):1-9.

  • Makwana V, Jain R, Patel K, Nivsarkar M, Joshi A. Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: elucidation of mechanism of uptake using chylomicron flow blocking approach. International journal of pharmaceutics. 2015;495(1):439-46.

  • Chattopadhyay N, Zastre J, Wong HL, Wu XY, Bendayan R. Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line. Pharmaceutical research. 2008;25(10):2262-71.

  • Desai J, Thakkar H. Darunavir-Loaded Lipid Nanoparticles for Targeting to HIV Reservoirs. AAPS Pharm Sci Tech. 2018;19(2):648-60.

  • Prasad BS, Gupta VR, Devanna N, Jayasurya K. Microspheres as Drug Delivery System–A Review. J global trends pharm sci. 2014;5(3):1961-72.

  • Kadam NR, Suvarna V. Microsphere: A Brief Review. Asian J Biomed pharm sci. 2015;5(47):13-9.

  • Dasari A, Velmurugan S. Formulation and evaluation of nevirapine mucoadhesive microspheres. Int J Pharm Pharm Sci. 2015;7(6):342-8.

  • Velmurugan S, Alla MA, Kumar P. Formulation and evaluation of ritonavir mucoadhesive microspheres. Journal of Chemical and Pharmaceutical Research, 2014, 6(5):952-960.

  • Ghosh A, Nayak UK, Rout P, Nag T, Roy P. Preparation, Evaluation and in vitro-in vivo Correlation (IVIVC) study of Lamivudine Loaded Microspheres. Research Journal of Pharmacy and Technology. 2008;1(4):353-6.

  • Reddy BV, Krishnaveni K. Formulation and evaluation of efavirenz microspheres. Der Pharmacia letters. 2015;7(6):1-9.

  • Bashir Khan A, Sharnagat Thakur R. Formulation and evaluation of mucoadhesive microspheres of tenofovir disoproxil fumarate for intravaginal use. Current drug delivery. 2014;11(1):112-22.

  • Asha K, Vikash D. Formulation and evaluation of zidovudine loaded chitosan microspheres for controlled release.Int. J. Drug Dev. and Res. 2012;4 (1): 96-105.

  • Murthy SK. Nanoparticles in modern medicine: state of the art and future challenges. Int J Nanomedicine 2007; 2(2): 129-41.

  • Ham AS, Cost MR, Sassi AB, Dezzutti CS, Rohan LC. Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles. Pharm Res 2009; 26(3): 502-11.

  • Kuo YC, Chen HH. Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across the in vitro bloodbrain barrier. Int J Pharm 2006; 327(1-2): 160-9.

  • Rao KS, Ghorpade A, Labhasetwar V. Targeting anti-HIV drugs to the CNS. Expert Opin Drug Deliv 2009; 6(8): 771-84.

  • Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C. Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnology 2010; 8: 1.

  • Bowman MC, Ballard TE, Ackerson CJ, Feldheim DL, Margolis DM, Melander C. Inhibition of HIV fusion with multivalent gold nanoparticles. J Am Chem Soc 2008; 130(22): 6896-7.

  • Rossi JJ, June CH, Kohn DB. Genetic therapies against HIV. Nat Biotechnol 2007; 25(12): 1444-54.

  • Mintzer MA, Simanek EE. Nonviral vectors for gene delivery. Chem Rev 2009; 109(2): 259-302.

  • Mitsuyasu RT, Merigan TC, Carr A, et al. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells. Nat Med 2009; 15(3): 285-92.

  • Pett SL. Immunotherapies in HIV-1 infection. Curr Opin HIV AIDS 2009; 4(3): 188-93.

  • Rinaldo CR. Dendritic cell-based human immunodeficiency virus vaccine. J Intern Med 2009; 265(1): 138-58.

  • Letvin NL. Progress and obstacles in the development of an AIDS vaccine. Nat Rev Immunol 2006; 6(12): 930-9.

  • Pascual A, Cachafeiro A, Funk ML, Fiscus SA. Comparison of an assay using signal amplification of the heat-dissociated p24 antigen with the Roche Monitor human immunodeficiency virus RNA assay. J Clin Microbiol 2002; 40(7): 2472-5.


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  • Novel Approaches in Nanoparticulate Drug Delivery System to Overcome Human Immunodeficiency Virus

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Authors

M. Roopa
Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore, Karnataka-560035, India
Arthi Mohan
Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore, Karnataka-560035, India

Abstract


The development of antiretroviral medication has considerably modified the perception of Human Immunodeficiency virus /Acquired immunodeficiency syndrome (HIV/AIDS) as a fatal to a last stage manageable sickness. The convenience and organization of antiretroviral medicinal consideration has essentially diminished mortality and horribleness related to HIV and AIDS. Antiretroviral drug deficiency remains a serious drawback in underserved populations worldwide. Partnerships among pharmaceutical corporations, tutorial investigators and government and nongovernment agencies is necessary to boost access to life-saving regimens. Nanomedicine opens new restorative roads for assaulting viral diseases and for enhancing treatment achievement rates. Significantly, nanomaterials like dendrimers and numerous other inorganic nanoparticles like gold, silver, zinc, and iron can be utilized for HIV treatment. Moreover, nanoparticles could best go about as adjuvants, convoys throughout vaccine delivery, nanomedicine could also be an appropriate methodology in HIV/AIDS treatment by methods for offering lower dose and aspect impact, better patient-to-persistent consistency and HIV diagnosis. This article explores the varied applicable methods for delivery of antiretroviral drugs within the style of liposomes, dendrimers, solid lipid nanoparticles, microspheres and polymeric nanoparticles. These approaches of delivery are verified to supply innovative and direct delivery of antiretroviral medication by enhancing the therapeutic effectiveness, targeting the location of action and increasing the activity and safety of the medication.

Keywords


Antiretroviral Drug, Drug Delivery, HIV, Nanocarriers, Nanomedicine.

References