Research Journal of Pharmacy and Technology

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Formulation Development and In vitro Characterization of Solid Self Nano Emulsifying Drug Delivery System for Curcumin to Target Colon Adenocarcinoma


Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
     

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Cancer is the abnormal growth of cells in any part of the body; where when we are considering the Indian scenario, colon cancer stand to be forth in men and third in woman with the respect to mortality and incidence rate. The different dosage forms are available, oral delivery is most prominent and economic option for cancer treatment. In this present era the cost of the parenteral dosage form is increasing day by day hence the use of the oral drug delivery is more prominent, economical and convenient option for the cancer treatment. Curcumin is a flavonoid used in our day to day life which is proven to have an anti-cancer activity. For providing a colon specific action curcumin spheroid were formulated containing curcumin loaded self-nano emulsifying drug delivery system (SNEDDS) were prepared and evaluated. DSC reports confirmed the purity of the curcumin to be 99.25%. From the Preformulation studies report the solubility of the curcumin was found to be at maximum in Capryol 90. After the preparation of spheroids its characterisation, in vitro studies were performed which revealed the maximum release of 88.91% at pH 6.8. From IC50 value was found to be 21.1μg/ml. Therefore, curcumin loaded or entrapped in SNEDDS were formulated to spheroids and can be useful for the treatment of colorectal cancer.

Keywords

Colon Cancer, Pectin, SNEDDS, Curcumin, in vitro Studies, Spheroids.
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  • Formulation Development and In vitro Characterization of Solid Self Nano Emulsifying Drug Delivery System for Curcumin to Target Colon Adenocarcinoma

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Authors

Chenmala Karthika
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
R. Sureshkumar
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
Dheepak Upadhyay
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
S. K. Janani
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
C. Vasanthi
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
M. Raja
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India
Sai Surya Nikitha Upathyayula
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to the JSS Academy of Higher Education and Research, Mysuru), India

Abstract


Cancer is the abnormal growth of cells in any part of the body; where when we are considering the Indian scenario, colon cancer stand to be forth in men and third in woman with the respect to mortality and incidence rate. The different dosage forms are available, oral delivery is most prominent and economic option for cancer treatment. In this present era the cost of the parenteral dosage form is increasing day by day hence the use of the oral drug delivery is more prominent, economical and convenient option for the cancer treatment. Curcumin is a flavonoid used in our day to day life which is proven to have an anti-cancer activity. For providing a colon specific action curcumin spheroid were formulated containing curcumin loaded self-nano emulsifying drug delivery system (SNEDDS) were prepared and evaluated. DSC reports confirmed the purity of the curcumin to be 99.25%. From the Preformulation studies report the solubility of the curcumin was found to be at maximum in Capryol 90. After the preparation of spheroids its characterisation, in vitro studies were performed which revealed the maximum release of 88.91% at pH 6.8. From IC50 value was found to be 21.1μg/ml. Therefore, curcumin loaded or entrapped in SNEDDS were formulated to spheroids and can be useful for the treatment of colorectal cancer.

Keywords


Colon Cancer, Pectin, SNEDDS, Curcumin, in vitro Studies, Spheroids.

References