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Evaluation of Hypoglycemic effect of Extracts from Derris scandens and Thunbergia erecta Leaves in Swiss albino mice


Affiliations
1 Department of Pharmacy, University of Development Alternative, 4/4, Block A, Lalmatia, Dhaka-1207, Bangladesh
2 Department of Pharmacy, Jagannath University, 9-10, Chittaranjan Ave, Dhaka-1100, Bangladesh
3 Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh
     

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Derris scandens and Thunbergia erecta are two medicinal plants have been identified to have many reported phytochemicals and significant medicinal value. Both of these medicinally valuable plants are available in Bangladesh as well as many other countries of the world. The objective of this study was to determine the hypoglycemic effects of extracts from leaves of two medicinal plants Derris scandens and Thunbergia erecta in Swiss albino mice. In vivo Oral Glucose Tolerance Test (OGTT) method was applied to measure the hypoglycemic effects of methanol extract of leaves of Derris scandens (MEDS) and methanol extract of leaves of Thunbergia erecta (METE). MEDS at doses 200 and 400 mg/kg BW reduced the blood glucose level by 23.45% and 29.62% respectively on the other hand METE reduced the blood glucose level by 22.22% and 40.74% at doses 200 and 400 mg/kg BW respectively. These percentage reduction of blood glucose levels for both MEDS and METE at doses 200 and 400 mg/kg BW were comparable with the blood sugar reduction potential (28.80%) showed by the standard drug glibenclamide at dose 10 mg/kg BW. This study manifest that both MEDS and METE have potency for hypoglycemic effects in the animal model.

Keywords

Derris scandens, Thunbergia erecta, Hypoglycemic, OGTT, Phytochemicals.
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  • Evaluation of Hypoglycemic effect of Extracts from Derris scandens and Thunbergia erecta Leaves in Swiss albino mice

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Authors

Md. Mahbubur Rahman Bhuiyan
Department of Pharmacy, University of Development Alternative, 4/4, Block A, Lalmatia, Dhaka-1207, Bangladesh
Ummey Jannatun Nahar
Department of Pharmacy, Jagannath University, 9-10, Chittaranjan Ave, Dhaka-1100, Bangladesh
Anawara Begum
Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh

Abstract


Derris scandens and Thunbergia erecta are two medicinal plants have been identified to have many reported phytochemicals and significant medicinal value. Both of these medicinally valuable plants are available in Bangladesh as well as many other countries of the world. The objective of this study was to determine the hypoglycemic effects of extracts from leaves of two medicinal plants Derris scandens and Thunbergia erecta in Swiss albino mice. In vivo Oral Glucose Tolerance Test (OGTT) method was applied to measure the hypoglycemic effects of methanol extract of leaves of Derris scandens (MEDS) and methanol extract of leaves of Thunbergia erecta (METE). MEDS at doses 200 and 400 mg/kg BW reduced the blood glucose level by 23.45% and 29.62% respectively on the other hand METE reduced the blood glucose level by 22.22% and 40.74% at doses 200 and 400 mg/kg BW respectively. These percentage reduction of blood glucose levels for both MEDS and METE at doses 200 and 400 mg/kg BW were comparable with the blood sugar reduction potential (28.80%) showed by the standard drug glibenclamide at dose 10 mg/kg BW. This study manifest that both MEDS and METE have potency for hypoglycemic effects in the animal model.

Keywords


Derris scandens, Thunbergia erecta, Hypoglycemic, OGTT, Phytochemicals.

References