Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Development and Characterization of Transdermal Patches of Tramadol Hydrochloride: An Approach to Pain Management


Affiliations
1 NKBR College of Pharmacy and Research Centre, Meerut, U.P. – 245206., India
     

   Subscribe/Renew Journal


Transdermal drug delivery leads direct access to the systemic circulation through the skin which bypass drug from the hepatic first pass metabolism leading to increase bioavailability. Because Tramadol hydrochloride has low bioavailability, it was selected as a model drug. The present study was aimed to develop and characterize transdermal patches of Tramadol hydrochloride by solvent casting method. Two polymers Ethyl cellulose (EC) and Poly vinyl pyrrrolidine (PVP) in different combination or alone were used to form matrix system. Dibutylpthlate and Glycerine were incorporated as plasticizers. All the patches were characterized for parameters like Thickness, Weight variation, Drug content uniformity, Tensile strength, % elongation, folding endurance, moister content, In-vitro drug permeation study etc. Amongst all formulations, formulation F6 had more desirable characteristic & shows 82.82% drug permeation in 10 hr. Release kinetic can be described by Higuchi model with anomalous diffusion as a release mechanism. The Transdermal patch formulated from Ethyl Cellulose (EC) and PVP showed satisfactory physicochemical properties. So, it can be concluded that such a matrix type patches of Ethyl Cellulose (EC) and PVP could be a good carrier in transdermal delivery of Tramadol HCl. FTIR studies showed there were no incompatibilities between drug and other excipients.

Keywords

Transdermal patch, Tramadol hydrochloride, PVP, Folding endurance, In vitro permeation.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Chein YW. Novel Drug Delivery Systems. 2nd ed. New York: Marcel Dekker; 1992; 1-2.

  • Tyle P. Drug Delivery Devices. Fundamentals and Applications. New York: Marcel Dekker; 1998; 385-417.

  • ChienYie W. Parenteral drug delivery and delivery systems. 2nd ed. New York: Marcel Dekker Inc; 1992; 301-50.

  • Elias PM. Lipids and the epidermal permeability barrier. Arch Dermatol. 1981, 270: 95-117.

  • Nikhil S. A review: Transdermal drug delivery system: A tool for novel drug delivery system. Int. J. Drug Dev. & Res..2011; 3(3): 70-84.

  • Patil R, Patil N, Patil A, Shid SJ, Dange VN, Magdum CS and Mohite SK. Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride. Asian J. Pharm. Tech. 2016; 6 (3): 183-185

  • Vasavi G, Haritha PN and Chandrashekar B. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Asian J. Res. Pharm. Sci. 2018; 8(3):123-129

  • Suja C., Ramasamy C. and Narayanacharyulu R. Development and Evaluation of Lisinopril Transdermal Patches. Research J. Pharm. and Tech. 4(8): August 2011; Page 1260-1264.

  • Patel RP, Patel G, Patel H and Baria A. Formulation and Evaluation of Transdermal Patch of Aceclofenac. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 108-115.

  • Jatav VS, Saggu JS , Sharma AK, Sharma A and Jat RK. Formulation and Evaluation of Transdermal Patches of Nebivolol Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2012; 4(5): 272-277

  • Megha B, Nagesh C, Devdatt Jani and Chandrashekhara S. Development and Evaluation of Transdermal Drug Delivery System using Natural Polysaccharides.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(5): 278-284.

  • Solanki SS, Patel KB, Patel JG, Patel MP and Patel JK. Development of Matrix Type Transdermal Patches of Granisetron Hydrochloride: Physicochemical and in-Vitro Characterization. Research J. Pharm. and Tech. 5(7): July 2012; Page 973-977.

  • Chakraborty P, Dey B K., Bahadur S, Thakkar S and Das S. Design, Development, Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose - Povidone Matrices. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 168-172.

  • Dey BK, Kar PK and Nath LK. Formulation Design, Preparation and In vitro – In vivo Evaluation of Propranolol Hydrochloride Transdermal Patches using Hydrophilic and Hydrophobic Polymer complex. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 155-160

  • Gaur S and Sharma A K. Development and Evaluation of Transdermal Drug Delivery System of Ivabradine Hydrochlride. Research J. Pharma. Dosage Forms and Tech. 2013; 5(4): 237-241.

  • Das A, Ghosh S, Das S, Dey B K and Ghosh T K. Formulation and In Vitro Evaluation of Transdermal Patches of Metformin Hydrochloride Using Hydrophilic and Hydrophobic Polymer Complex. Research J. Pharm. and Tech. 4(4): April 2011; Page 561-565.

  • Lal N and Verma N. Development and Evaluation of Transdermal Patches containing Carvedilol and Effect of Penetration Enhancer on Drug Release. Research J. Pharm. and Tech 2018; 11(2):745-752.

  • Hussain I, Kumar R, Narayanaswamy VB, Haque I andHoque M. Design and Evaluation of Transdermal Patches Containing Risperidone. Asian J. Res. Pharm. Sci. 2016; 6(4): 208-222.

  • Bavaskar SR, Agrawal AD, Agrawal YS, Amrutkar AN and Kawatikwar PS. Spectrophotometric Estimation of Tramadol Hydrochloride in Bulk and Tablet Dosage Form. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 714-715.

  • Rao V, Mamatha T, Mukkanti K and Ramesh. Transdermal drug delivery system for atomoxetine hydrochloride – in vitro and ex vivo evaluation. Current Trends in Biotechnology and Pharmacy 2009; 3(2):188-96


Abstract Views: 102

PDF Views: 0




  • Development and Characterization of Transdermal Patches of Tramadol Hydrochloride: An Approach to Pain Management

Abstract Views: 102  |  PDF Views: 0

Authors

Pooja Dhama
NKBR College of Pharmacy and Research Centre, Meerut, U.P. – 245206., India
Sachin Kumar
NKBR College of Pharmacy and Research Centre, Meerut, U.P. – 245206., India
Manoj Kumar Sagar
NKBR College of Pharmacy and Research Centre, Meerut, U.P. – 245206., India

Abstract


Transdermal drug delivery leads direct access to the systemic circulation through the skin which bypass drug from the hepatic first pass metabolism leading to increase bioavailability. Because Tramadol hydrochloride has low bioavailability, it was selected as a model drug. The present study was aimed to develop and characterize transdermal patches of Tramadol hydrochloride by solvent casting method. Two polymers Ethyl cellulose (EC) and Poly vinyl pyrrrolidine (PVP) in different combination or alone were used to form matrix system. Dibutylpthlate and Glycerine were incorporated as plasticizers. All the patches were characterized for parameters like Thickness, Weight variation, Drug content uniformity, Tensile strength, % elongation, folding endurance, moister content, In-vitro drug permeation study etc. Amongst all formulations, formulation F6 had more desirable characteristic & shows 82.82% drug permeation in 10 hr. Release kinetic can be described by Higuchi model with anomalous diffusion as a release mechanism. The Transdermal patch formulated from Ethyl Cellulose (EC) and PVP showed satisfactory physicochemical properties. So, it can be concluded that such a matrix type patches of Ethyl Cellulose (EC) and PVP could be a good carrier in transdermal delivery of Tramadol HCl. FTIR studies showed there were no incompatibilities between drug and other excipients.

Keywords


Transdermal patch, Tramadol hydrochloride, PVP, Folding endurance, In vitro permeation.

References