Research Journal of Pharmacy and Technology

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In-vitro Antifungal Evaluation of Some Cu and Ni Complexes


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1 Department of Chemistry, Jaipur National University, Jaipur-302017, Rajasthan,, India
     

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The interaction of Copper and Nickel chloride with oximes of 2-Acetylfuran, 2-Acetylthiophene and 2-Acetylpyridine in absence of an external base resulted in formation of the complexes of the type [MCl2L2] (A) and [MCl2L2].H2O (A.H2O) {Here M: Cu or Ni; L: HON=C(CH3) Ar; where Ar = C4H3S, C4H3O or C5H4N}. The parent ligands were synthesized by green method using water as a solvent. Complexes were characterized by elemental analysis, 1H-NMR, IR spectral studies and these spectra were compared with that of free ligands. Spectral measurements suggest an octahedral or distorted octahedral geometry for all these complexes. The in-vitro Antifungal activity of all these complexes has proven that they are active against Candida albicans even at lower concentrations.

Keywords

Oximes, Transition Metal Complexes, Copper Complexes, Nickel Complexes, Antifungal Activity.
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  • In-vitro Antifungal Evaluation of Some Cu and Ni Complexes

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Authors

Purnima Nag
Department of Chemistry, Jaipur National University, Jaipur-302017, Rajasthan,, India
Deepankar Sharma
Department of Chemistry, Jaipur National University, Jaipur-302017, Rajasthan,, India

Abstract


The interaction of Copper and Nickel chloride with oximes of 2-Acetylfuran, 2-Acetylthiophene and 2-Acetylpyridine in absence of an external base resulted in formation of the complexes of the type [MCl2L2] (A) and [MCl2L2].H2O (A.H2O) {Here M: Cu or Ni; L: HON=C(CH3) Ar; where Ar = C4H3S, C4H3O or C5H4N}. The parent ligands were synthesized by green method using water as a solvent. Complexes were characterized by elemental analysis, 1H-NMR, IR spectral studies and these spectra were compared with that of free ligands. Spectral measurements suggest an octahedral or distorted octahedral geometry for all these complexes. The in-vitro Antifungal activity of all these complexes has proven that they are active against Candida albicans even at lower concentrations.

Keywords


Oximes, Transition Metal Complexes, Copper Complexes, Nickel Complexes, Antifungal Activity.

References