Research Journal of Pharmacy and Technology

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Development and in Vitro Evaluation of a Large-intestinal Drug Delivery System


Affiliations
1 Faculty of Pharmacy, Philadelphia University, Amman,, Jordan
2 Faculty of Pharmacy, Jordan University of Science and Technology, Irbid,, Jordan
     

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The development of large intestinal drug delivery systems has gained increased attention for the effective treatment of some associated disorders, such as ulcerative colitis, where the therapeutic agent acts locally on the affected parts. The main aim of this study was to develop polymerized carriers capable to deliver drugs effectively to the lower part of the gastrointestinal tract (large intestine). Polymeric pellets, based on hydroxyethyl methacrylate with different crosslinker concentrations, were synthesized using a bulk polymerization method. Mesalazine, which is frequently used to treat inflammatory disorders associated with the large intestine, was selected as a model drug. Swelling and in vitro release studies were performed to assess the developed systems and study the effect of the crosslinker concertation. The swelling and release profiles have decreased significantly with increasing the crosslinker concertation. The produced pellets exhibited a delayed-controlled drug release up to 24 hours, which indicated their potential applicability as successful large-intestinal drug delivery systems.

Keywords

Ulcerative colitis, Specific delivery system, Inflammatory bowel disease, Drug targeting, Mesalazine.
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  • Sudarshan S, Sangeeta S, Sheth NR, Roshan P, Ushir YV, Gendle R. Colon specific drug delivery system of mesalamine for eradication of ulcerative colitis. Research Journal of Pharmacy and Technology. 2009; 2(4): 819-823.

  • Jain P, Parkhe G. Alternative Colon Targeted Drug Delivery Approaches for the Treatment of Inflammatory Bowel Disease. Research Journal of Pharmacy and Technology. 2020; 13(11): 5562-5568.

  • Bayan MF, Bayan RF. Recent advances in mesalamine colonic delivery systems. Future Journal of Pharmaceutical Sciences. 2020; 6(1): 1-7.

  • Bayan MF. Drug Release Control and Enhancement Using Carriers with Different Concentrations of Capmul® MCM C8. International Journal of Applied Pharmaceutics. 2021; 13(1): 249-252.

  • Ugandhar C. Formulation and Evaluation of Mesalazine Solid Dispersion. Research Journal of Pharmacy and Technology. 2012; 5(6): 809-812.

  • Akshaya K, Chitra V. A review on Pathological state and herbal remedies on ulcerative colitis. Research Journal of Pharmacy and Technology. 2019; 12(3): 1409-1417.

  • Rehman F, Rahim A, Airoldi C, Volpe PL. Preparation and characterization of glycidyl methacrylate organo bridges grafted mesoporous silica SBA-15 as ibuprofen and mesalamine carrier for controlled release. Materials Science and Engineering: C. 2016; 59: 970–979.

  • Mirabbasi F, Dorkoosh FA, Moghimi A, Shahsavari S, Babanejad N, Seifirad S. Preparation of mesalamine nanoparticles using a novel polyurethane-chitosan graft copolymer. Pharmaceutical Nanotechnology. 2017; 5(3): 230–239.

  • Kadam SD, Dhole S, Chitlange S. Formulation and evaluation of sustained release colon targeted mesalamine tablet. Research Journal of Pharmacy and Technology. 2020; 13(5): 2241-2245.

  • Gyles DA, Castro LD, Silva JOC, Ribeiro-Costa RM. A review of the designs and prominent biomedical advances of natural and synthetic hydrogel formulations. European Polymer Journal. 2017; 88: 373-392.

  • Cretu A, Gattin R, Brachais L, Barbier-Baudry D. Synthesis and degradation of poly (2-hydroxyethyl methacrylate)-graft-poly (ε-caprolactone) copolymers. Polymer Degradation And Stability. 2004; 83(3): 399-404.

  • Kumar NA, Ganapathy HS, Kim JS, Jeong YS, Jeong YT. Preparation of poly 2-hydroxyethyl methacrylate functionalized carbon nanotubes as novel biomaterial nanocomposites. European Polymer Journal. 2008; 44(3): 579-586.

  • Pradeepkumar P, Subbiah A, Rajan M. Synthesis of bio-degradable poly (2-hydroxyethyl methacrylate) using natural deep eutectic solvents for sustainable cancer drug delivery. SN Applied Sciences. 2019; 1(6): 568.

  • Jain A, Bajpai J, Bajpai AK, Mishra A. Thermoresponsive cryogels of poly (2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide)(P (HEMA-co-NIPAM)): fabrication, characterization and water sorption study. Polymer Bulletin. 2020; 77(8): 4417-4443.

  • Roointan A, Farzanfar J, Mohammadi-Samani S, Behzad-Behbahani A, Farjadian F. Smart pH responsive drug delivery system based on poly (HEMA-co-DMAEMA) nanohydrogel. International Journal of Pharmaceutics. 2018; 552(1-2): 301-311.

  • Zia MA, Sohail M, Minhas MU, Sarfraz RM, Khan S, de Matas M, et al. HEMA based pH-sensitive semi IPN microgels for oral delivery; a rationale approach for ketoprofen. Drug Development and Industrial Pharmacy. 2020; 46(2): 272-282.

  • Obaidat RM, Tashtoush BM, Bayan MF, Al Bustami RT, Alnaief M. Drying using supercritical fluid technology as a potential method for preparation of chitosan aerogel microparticles. AAPS PharmSciTech. 2015; 16(6): 1235-1244.

  • Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010; 67(3): 217-223.

  • Datta P, Rewers-Felkins K, Kallem RR, Baker T, Hale TW. Determination of mesalamine levels in human milk as a function of dose. Breastfeeding Medicine. 2019; 14(2): 98-101.

  • Emerson JA, Toolan DT, Howse JR, Furst EM, Epps III TH. Determination of solvent–polymer and polymer–polymer Flory–Huggins interaction parameters for poly (3-hexylthiophene) via solvent vapor swelling. Macromolecules. 2013; 46(16): 6533-6540.

  • Tran NPD, Yang MC. Synthesis and characterization of silicone contact lenses based on TRIS-DMA-NVP-HEMA hydrogels. Polymers. 2019; 11(6): 944.

  • Nagpal M, Singh SK, Mishra D. Synthesis characterization and in vitro drug release from acrylamide and sodium alginate based superporous hydrogel devices. International Journal of Pharmaceutical Investigation. 2013; 3(3): 131-140.

  • Garnica-Palafox IM, Sánchez-Arévalo FM. Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels. Carbohydrate Polymers. 2016; 151: 1073-1081.

  • Onoyima CC, Okibe FG, Sholadoye QO. Kinetics and mechanisms of doxorubicin release from hydroxyapatite-sodium alginate nanocomposite. Nigerian Journal of Pharmaceutical and Applied Science Research. 2020; 9(3): 7-13.

  • Sharma P, Tailang M. Design, optimization, and evaluation of hydrogel of primaquine loaded nanoemulsion for malaria therapy. Future Journal of Pharmaceutical Sciences. 2020; 6(1): 1-11.

  • Kadam SD, Dhole S, Chitlange S. Formulation and Evaluation of Sustained Release Colon Targeted Mesalamine Tablet. Research Journal of Pharmacy and Technology. 2020; 13(5): 2241-2245.

  • Raj SB, Chandrasekhar KB, Reddy KB. Formulation, in-vitro and in-vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system. Future Journal of Pharmaceutical Sciences. 2019; 5(1): 1-14.

  • Rezaei A, Nasirpour A. Evaluation of release kinetics and mechanisms of curcumin and curcumin-β-cyclodextrin inclusion complex incorporated in electrospun almond gum/PVA nanofibers in simulated saliva and simulated gastrointestinal conditions. BioNanoScience. 2019; 9(2): 438-445.

  • Gupta P, Purwar R. Electrospun pH responsive poly (acrylic acid-co-acrylamide) hydrogel nanofibrous mats for drug delivery. Journal of Polymer Research. 2020; 27(10): 1-10.

  • Quintanilla de Stéfano JC, Abundis-Correa V, Herrera-Flores SD, Alvarez AJ. pH-sensitive starch-based hydrogels: synthesis and effect of molecular components on drug release behavior. Polymers. 2020; 12(9): 1974.


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  • Development and in Vitro Evaluation of a Large-intestinal Drug Delivery System

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Authors

Mohammad F. Bayan
Faculty of Pharmacy, Philadelphia University, Amman,, Jordan
Mutaz S. Salem
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid,, Jordan
Rana F. Bayan
Faculty of Pharmacy, Philadelphia University, Amman,, Jordan

Abstract


The development of large intestinal drug delivery systems has gained increased attention for the effective treatment of some associated disorders, such as ulcerative colitis, where the therapeutic agent acts locally on the affected parts. The main aim of this study was to develop polymerized carriers capable to deliver drugs effectively to the lower part of the gastrointestinal tract (large intestine). Polymeric pellets, based on hydroxyethyl methacrylate with different crosslinker concentrations, were synthesized using a bulk polymerization method. Mesalazine, which is frequently used to treat inflammatory disorders associated with the large intestine, was selected as a model drug. Swelling and in vitro release studies were performed to assess the developed systems and study the effect of the crosslinker concertation. The swelling and release profiles have decreased significantly with increasing the crosslinker concertation. The produced pellets exhibited a delayed-controlled drug release up to 24 hours, which indicated their potential applicability as successful large-intestinal drug delivery systems.

Keywords


Ulcerative colitis, Specific delivery system, Inflammatory bowel disease, Drug targeting, Mesalazine.

References