Open Access
Subscription Access
Open Access
Subscription Access
Evaluation of Dextromethorphan Hbr and Glyceryl Guaiacolate Mixture in Syrup Preparation by Derivative Spectrophotometry Methods
Subscribe/Renew Journal
The derivative spectrophotometric methods are the goal of evaluating the simultaneous level of Dextromethorphan HBr and Glyceryl Guaiacolate mixture in Syrup. The determination of the mixture is used the derivative spectrophotometry method with methanol-water (50:50) for Dextromethorphan HBr and Glyceryl Guaiacolate. The derivative spectrophotometric method on 1st derivatization with Δλ 2 nm have wavelength 263.6 nm for Dextromethorphan HBr and 2nd derivatization with Δλ 2 nm at 285 nm for Glyceryl guaiacolate, The locally producted syrup samples met the level requirements mixture of Dextromethorphan and Glyceryl guaiacolate less than 90.0% and not over 110.0% of the amount stated on the label. The validation test showed that these two methods had met the validation parameter. The derivative spectrophotometry method was used to determine a mixture of Dextromethorphan HBr and Glyceryl guaiacolate and fulfilling the validation requirements and level requirements according to USP 30.
Keywords
Dextromethorphan HBr, Derivative spectrophotometry, Glyceryl guaiacolate, Validation.
Subscription
Login to verify subscription
User
Font Size
Information
- G1 oodman and Gilman’s The Pharmacological Basis of Therapeutics.Goodman, GA, Hardman JG, and Limbird LE. Editor. 10th Ed, The McGraw-Hill Companies, Inc, Medical Publishing Division, 2006; p.117. DOI: 10.1036/0071422803
- Indonesian Pharmacopoeia, Fifth edition, Jakarta, Ministry of Health of the Republic of Indonesia, 2014; p. 498, 848, 1077.
- The United States Pharmacopeia, USP 30.The National Formulary, NF XXII, Rockville, MD: U.S Pharmacopeial Convention, Inc. 1989; p. 1293.
- Analysis of Drugs and Poisons, Moffat AC, Osselton MD, Widdop B, and Galichet LY. Editors. Clarke’s 4th ed, London, Pharmaceutical Press. 2011. p. 1087. 1468, 1856.
- Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril by UV-Spectrophotometric Method in Pharmaceutical Dosage Form. Vanaja N, Preethi Ch, Manjunath SY, Krishanu Pal. Asian J. Pharm. Ana. 2015;5(4):, 2015; Page 187-194. DOI: 10.5958/2231-5675.2015.00030.7
- Development and Validation of RP-HPLC method for simultaneous Estimation of Metformin HCl and Gliclazide. Pawar J, Sonawane S, Chhajed S , Kshirsagar S. Asian J. Pharm. Ana. 2016; 6(3): p. 151-154. DOI: 10.5958/2231-5675.2016.00024.7
- Development and Validation of UV Spectrophotometric Method for The Simultaneous Estimation of Rosuvastatin and Ezetimibe in Pharmaceutical Dosage Form.Sireesha. D, Monika ML, Bakshi V. Asian J. Pharm. Ana. 2017; 7(3): pp 135-140. DOI: 10.5958/2231-5675.2017.00021.7.
- Validated Derivative Spectrophotometric method for simultaneous estimation of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride from tablet formulations.Dyade GK. Asian J. Pharm. Ana. 2019; 9(1):01-04. DOI: 10.5958/2231-5675.2019.00001.29.
- Development and Validation of HPLC Method for the Estimation of Metaxalone in Spiked Human Plasma. Gangurde P, Sonawane S, Kshirsagar S, and Chhajed S. Asian J. Pharm. Ana. 2019; 9(4): p.210-214. DOI: 10.5958/2231-5675.2019.00035.8
- Method Development and Validation for Simultaneous Estimation of Telmisartan and Chlorthalidone by RP-HPLC in Pharmaceutical Dosage Form. Vanaja N, Preethi CH, Manjunath SY, and Krishanu Pal K. Asian J. Pharm. Ana. 2015; 5(4): p 171-177. DOI: 10.5958/2231-5675.2015.00027.7
- Implementation UV-Spectrophotometry approach for Determination of Tamsulosin HCl in tablets using area under Curve Technique. Prajakta D. Mhaske, Burhan A. Bohari, Suraj R. Chaudhari, Pritam S. Jain, Atul A. Shirkhedkar. Asian J. Pharm. Ana. 2020; 10(2): 86-90. DOI: 10.5958/2231-5675.2020.00015.0
- Simultaneous Spectrophotometric Estimation of Naphazoline Nitrate and Hydrocortisone in Nasal drops. Jetal Patel, Dhara Patel, Sharav Desai. Asian J. Pharm. Res. 2016; 6(2): 61-66. DOI: 10.5958/2231-5691.2016.00011.3
- Validated First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Lansoprazole and Aspirin in Tablet G. Kumaraswamy, Repudi. Lalitha, D. Sudheer Kumar . Dosage Forms. Asian J. Res. Pharm. Sci. 2016; 6(3): 185-190. DOI: 10.5958/2231-5659.2016.00025.4.
- New potentiometric and spectrophotometric methods for the determination Dextromethorphan in pharmaceutical preparations. Elmosallamy MA, and Amin ASAnal Sci 2014;30:pp. 419-425.
- A Review on UV Spectrophotometric Method for Estimation of Dextromethorphan in Bulk and Syrup Formulation by Area Under Curve Method. Kamal AH, El-Malla SF, and Hammad SF. International Journal of Pharmaceutical ang Chemical Science. 2016; 2(4): pp. 348-360
- Development of UV spectroscopic method for the determination of guaifenesin in bulk and formulation Pushpalatha E, Tejaswini P, Najboonbi M, Vineesha S, Madhanna MD, and Kumar TA.. Int J Pharm Res Anal 2015;5: pp. 90-95.
- Analytical Method Development and Validation of Stability Indicating assay method of analysis for Dolutegravir/Lamivudine/Tenofovir Disoproxil Fumarate tablets using High Performance Liquid ChromatographySaravanan. R, Somanathan. T, Gavaskar D, Tamilvanan M. Research Journal of Pharmacy and Technology. 2021; 14(5):2434-9. DOI: 10.52711/0974-360X.2021.00428 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-12
- High performance liquid chromatographic method for the determination of guaifenesin in pharmaceutical syrups and in environmental samples. Ahmed NR, and Lottfi SN. Baghdad Sci J 2012;10:pp. 1014-1021.
- Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine Aluri JB, and Stavchansky. Journal of Pharmaceutical and Biomedical Analysis. 1993;11(9): pp. 803-808. DOI:10.1016/0731-7085(93)80072-9
- Determination of Guaifenesin and Dextromethorphan by UPLC. Suneetha G, Venkateswarlu P, and Prasad PSS Der Pharma Chemica. 2012; 4 (3): pp.1019-1025.
- Pharmaceutical Chemistry Analysis. Rohman A, First print, Yogyakarta: Student Library.Yogyakarta: Student library. 2007; p. 220-262
- Bioanalytical Method Validation. Kadam AS, Pimpodkar NV, Gaikwad PS, and Chavan SD.. Asian J. Pharm. Ana. 2015;5(4): p219-225
- Implementation Guidelines and the Calculation Method Validation. Harmita F. Jakarta: Pharmaceutical Science Magazine; 2004, pp. 118-20.
- An Overview of Concept of Pharmaceutical Validation Raul SK, Padhy GK, Mahapatra AK, and Charan SA.. Research J. Pharm. and Tech. 2014; 7(9): p. 1081-1090.
- A Guide to Best Practice: Method Validation in Pharmaceutical Analysis. Ermer J. and Miller JH. Weinheim: Wiley-Vch Verlag GmBH & Co. KGaA. 2005;
Abstract Views: 137
PDF Views: 0