Research Journal of Pharmacy and Technology

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Synthesis of Novel 6-(Chloromethyl) - N2- (1 - (4-substituted Phenyl) - 3-phenyl - 1h-pyrazol - 4-yl) Methylene)-n4- Aryl-1, 3, 5-triazine - 2, 4-diamine Derivatives and Their Antimicrobial Activity


Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, UP.,, India
2 Associate professer Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001,, India
     

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A series of 6-(chloromethyl)-N2-(1-(4-substituted phenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4-aryl-1, 3, 5-triazine - 2, 4-diamine 7(Aa-Gd) were synthesized using the appropriate synthetic procedure and characterized by spectral analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. The antibacterial activity was evaluated against Gram-positive strains (Staphylococcus aureus, Streptococcus aureus) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) using benzyl penicillin and streptomycin as standard drugs. Further, these compounds were studied for antifungal activity against three strains of fungi (Candida albicans, Aspergillus fumigate and Aspergillus flavus) using Ketoconazole as a standard drug. In the presented study all the synthesized compounds showed significant antibacterial and antifungal activities.

Keywords

Triazine, Pharmacophore, Antibacterial, Antifungal, Heterocyclic.
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  • Synthesis of Novel 6-(Chloromethyl) - N2- (1 - (4-substituted Phenyl) - 3-phenyl - 1h-pyrazol - 4-yl) Methylene)-n4- Aryl-1, 3, 5-triazine - 2, 4-diamine Derivatives and Their Antimicrobial Activity

Abstract Views: 142  |  PDF Views: 0

Authors

Neelottama Kushwaha
Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, UP.,, India
C.S. Sharma
Associate professer Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001,, India

Abstract


A series of 6-(chloromethyl)-N2-(1-(4-substituted phenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4-aryl-1, 3, 5-triazine - 2, 4-diamine 7(Aa-Gd) were synthesized using the appropriate synthetic procedure and characterized by spectral analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. The antibacterial activity was evaluated against Gram-positive strains (Staphylococcus aureus, Streptococcus aureus) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) using benzyl penicillin and streptomycin as standard drugs. Further, these compounds were studied for antifungal activity against three strains of fungi (Candida albicans, Aspergillus fumigate and Aspergillus flavus) using Ketoconazole as a standard drug. In the presented study all the synthesized compounds showed significant antibacterial and antifungal activities.

Keywords


Triazine, Pharmacophore, Antibacterial, Antifungal, Heterocyclic.

References