Research Journal of Pharmacy and Technology

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Clinical Significance of Erythrocyte Sedimentation Rate in Tuberculosis


Affiliations
1 Professor of Pathology, Saveetha Medical College, Thandalam, Chennai , Tamilnadu, India
2 AHS MLT, Saveetha Medical College, Thandalam, Chennai , Tamilnadu, India
3 Stanley Medical College, Chennai, Tamilnadu., India
     

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Background: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis and still it is a common disease in developing countries. A variety of hematological parameters are studied in tuberculous patients such as decreased Hb(anemia), increased WBC count, increased ESR, and thrombocytopenia. Nowadays TB is a curable and preventable disease. The present study was undertaken to study the ESR values in TB patients and compare their values with ZiehlNelson staining. Method: The present study was carried out on 328 patients who had sputum smear-positive for AFB. based on the recommendation of the RNTCP grading system of AFB in Sputum ZiehlNelson staining, the cases of PTB group were further categorized into four subgroups AFB– 3+, AFB – 2+, AFB –1+ and scanty. The ESR was performed by a rapidly modified Westergren method on EDTA whole blood sample. Results: out of the 324 cases of tuberculosis collected from our hospital, male 252, female 72 from 14-80 years of age. ESR was elevated in patients with an increased grading of sputum positive (3+). The distribution of the mean value of, ESR in different grades of ZN staining of sputum in AFB positive patients was scanty(35.5), 1+(27.5), 2+(30.2),3+(42.4). respectively. Conclusion: Our study concluded that active TB is associated mostly with very high ESR values (≥ 100 mm/h) and with markedly raised values in all the grades of sputum AFB positive patients.

Keywords

Tuberculosis, erythrocyte sedimentation rate, Westergreens Method, AFB positive, ZN staining.
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  • Banerjee M, Chaudhary BL, Shukla S. Hematological profile among pulmonary tuberculosis patients in tertiary care Hospital. International Journal of Bioassays.2015;4(05):3900-2.

  • Yaranal PJ, Umashankar T, Harish SG. Hematological profile in pulmonary tuberculosis. Int J Helth Rehbil Sci.2013;2(1):50-5.

  • Uma Sankarviriti, Swarna Latha Surakala, Arun Satyadev Sidhanadam, Neelima Peela. Influence of HIV, Malnutrition and Patient Non-Compliance on the Prevalence and Prognosis of Tuberculosis: A Fatal Infectious Disease. Research J. Pharm. and Tech. 8(10): Oct., 2015; Page 1365-1368.

  • Olaniyi JA, Aken ‘Ova YA.Haematological profile of patients with pulmonary tuberculosis in Ibadan, Nigeria. Afr J Med Sci 2003; 32:239-42.

  • Levay PF, Retief JF.Causes of high erythrocyte sedimentation rates in an in patient population.SAfr Med J 2005;95(1):45-46.

  • AL-Marri MR, Kirkpatrick MB.Erythrocyte sedimentation rate in childhood tuberculosis is it still worthwhile? Int J Tuberc Lung Dis 2000;4:237-239.

  • Blumberg HM, Burman WJ, Chaisson RE. American Throacic Society/ Centers for Disease Control and Prevention/ Infectious Diseases Society of America: treatment for TB.Am J Resp Criti Care Med. 2003;167(4):603-662.

  • Mirsacidi SM, Tabarsi P, Amiri MV. Clinical and radiological presentation of adult tuberculous spondylitis. Tanaffos 2003;2:59-65.

  • Lama Doya, Danial Dalloul, Mohammad Alkhayer, Haissam Yazigi. The importance of diagnosing Mycobacterium tuberculosis by real time PCR Compared with the approved diagnostic methods in the Clinical Laboratory. Research J. Pharm. and Tech 2018; 11(4): 1513-1515.

  • Oleg A. Zemlyansky., Elena B. Tyurina., Andrey A. Bashkirev., Elena V. Kalyuzhnaya., Ludmila O. Zemlyanskaya. Experience and Efficiency of Laboratory Diagnosis of Tuberculosis with PCR Detector System GeneXpert in Belgorod Region. Research J. Pharm. and Tech. 2017; 10(3): 743-746.

  • Sandip Zine, Shweta A. Patankar, Sushmita S. Raopati. Rise of Antibiotic Resistance in Tuberculosis. Research J. Pharm. and Tech 2018; 11(7): 3201-3204.

  • Bala J, Bagdi R, BediS,KumarA.Tuberculosis As A cause of change in Hematological Parameters In A Teritiary Care Hospital.Natl J Integr Res Med 2015;6(4):31-35.

  • Thatoi PK, Khadanga S.Pulmonary Tuberculosis and its haematological correlates. Thatoi PK/ Transworld Medical Journal. 2013; 1(1):1113.

  • Hungund BR, Sangolli SS, Bannur HB. Blood and bone marrow findings in tuberculosis in adults-A cross sectional study. Al Ameen J Med Sci.2012;5(4):362-6.

  • Zaman K. Tuberculosis a global health problem J of health, Population and Nutrition. 2010;1:111-3. 16. Vijaya Kumar S, Nookala L, Prakash S, Vivean PR. Ziehl-Neelsen (ZN) Stained Method: Presence and Absence of Acid Fast Bacilli (AFB) of Pulmonary and Non Pulmonary Tuberculosis Patients Under Went Anti-Tuberculosis Treatment. Research J. Pharm. and Tech. 8(5): May, 2015; Page 529-532.

  • Amany SH. Jabe, Kadhimmohan Manhi, Imanhadi Alfayyadh, Saad S. Hamim. Prevalence of Tuberculosis from 2010-2015 in Nasiriyah City/Iraq. Research J. Pharm. and Tech. 2019; 12(5):2275-2278.

  • Ukpe IS, Southern L. Erythrocyte sedimentation rate values in active tuberculosis with and without HIV co-infection.SAfr Med J2006;96:427-428.

  • Muhammad Yousuf, Salih Bin Salih, Sameera Al-Johani, Adel Alothman. “Erythrocyte sedimentation rate at diagnosis in culturepositive cases of active tuberculosis” Pak J Med Sci January – March 2012 Vol. 28 No. 1 87-90.

  • Sarkar K, Baraily S, Dasgupta S. Erythrocyte sedimentation rate maybe an indicator for screening of tuberculosis patients for underlyingHIV infection, particularly in resource-poor settings: An experiencefrom India. J Health Popul Nutr 2004; 22:220-221.

  • Chakraborti AK, Dutta AK, Dasgupta B. Hematological changes in disseminates tuberculosis. Ind J Tuber.1995;42:165-8.

  • Janssens A, Rodeghiero F, Anderson D, Chong BH, Boda Z, Pabinger I, et al. Changes in bone marrow morphology in adults receiving romiplostim for the treatment of thrombocytopenia associated with primary immune thrombocytopenia. Annals of Hematology. 2016;95(7):1077-87.

  • Roy RK, Roy DK, Rupak KC, Patel I, Poudel K, Shah P, Bhuyan S, Bhuyan SK,Bhuyan R. Knowledge regarding Tuberculosis among undergraduate medical students at Nepalgunj Medical College - Banke, Nepal. Research J. Pharm. and Tech 2020; 13(6): 2833-2837.

  • P. Mangala Gowri, G. Bhuvaneswari, C. Manoj, R. Varatharajan, Subhashini, Jomcy, Epsimal. Assess the knowledge and associated factors of DOTS defaulter among Tuberculosis clients. Research J. Pharm. and Tech 2018; 11(6):2313-2316.

  • Susi Ari Kristina, Tri Murti Andayani, Galih Putri Wulandari. A Systematic Review of the Direct and Indirect Costs among Tuberculosis Patients. Research J. Pharm. and Tech. 2020; 13(1): 456-460.

  • Sr. Prabha Grace. A Personal Experience with a Tuberculosis patient: A Case Report. Int.J of Advances in Nur. Management. 2018; 6(4): 290-292.


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  • Clinical Significance of Erythrocyte Sedimentation Rate in Tuberculosis

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Authors

Sonti Sulochana
Professor of Pathology, Saveetha Medical College, Thandalam, Chennai , Tamilnadu, India
Gayathri
AHS MLT, Saveetha Medical College, Thandalam, Chennai , Tamilnadu, India
Jalvadi Rahul Siddartha
Stanley Medical College, Chennai, Tamilnadu., India
Jennifer fathima
AHS MLT, Saveetha Medical College, Thandalam, Chennai , Tamilnadu, India

Abstract


Background: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis and still it is a common disease in developing countries. A variety of hematological parameters are studied in tuberculous patients such as decreased Hb(anemia), increased WBC count, increased ESR, and thrombocytopenia. Nowadays TB is a curable and preventable disease. The present study was undertaken to study the ESR values in TB patients and compare their values with ZiehlNelson staining. Method: The present study was carried out on 328 patients who had sputum smear-positive for AFB. based on the recommendation of the RNTCP grading system of AFB in Sputum ZiehlNelson staining, the cases of PTB group were further categorized into four subgroups AFB– 3+, AFB – 2+, AFB –1+ and scanty. The ESR was performed by a rapidly modified Westergren method on EDTA whole blood sample. Results: out of the 324 cases of tuberculosis collected from our hospital, male 252, female 72 from 14-80 years of age. ESR was elevated in patients with an increased grading of sputum positive (3+). The distribution of the mean value of, ESR in different grades of ZN staining of sputum in AFB positive patients was scanty(35.5), 1+(27.5), 2+(30.2),3+(42.4). respectively. Conclusion: Our study concluded that active TB is associated mostly with very high ESR values (≥ 100 mm/h) and with markedly raised values in all the grades of sputum AFB positive patients.

Keywords


Tuberculosis, erythrocyte sedimentation rate, Westergreens Method, AFB positive, ZN staining.

References