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Potency of Nigella Sativa Linn. Seed as Antidiabetic (Preclinical Study)


Affiliations
1 Medical faculty of Universitas Muhammadiyah Surakarta, Indonesia
2 Pharmacy faculty of Universitas Muhammadiyah Surakarta, Indonesia
     

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Background: Nigella sativa is reported to have an antioxidant effect, so allegedly has anti-diabetic effect. Objectives:The aim of this study is to explore ethyl acetate fraction of ethanol extract of Nigela sativa Linn. (EANS) effect toward blood glucose level in diabetic rats induced by alloxan. Materials and Methods: Twenty five male rats (150–200 g). The rats were divided into five groups in which there were 5 rats in each group. Group I was treated by glibenclamide 0.63 mg/kg bw (positive control); Group II was treated by aqueous 2,5 ml/200 g bw (negative control); and Groups III; IV and V were treated by ethyl acetate of ethanol extract of N. sativa seed at a dosage of 250 mg/kg bw; 500 mg/kg bw and 1000mg/kg bw respectively. Results: The results of this study are EANS can reduced blood glucose level on diabetic rats induced by alloxan. Nigella sativa has potencies anti-diabetic effect. Conclusion: Nigella sativa Linn. seed has potency as anti-diabetic candidate.

Keywords

Nigella sativa, anti-diabetic, ethyl acetate.
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  • Potency of Nigella Sativa Linn. Seed as Antidiabetic (Preclinical Study)

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Authors

Em Sutrisna
Medical faculty of Universitas Muhammadiyah Surakarta, Indonesia
Tanti azizah
Pharmacy faculty of Universitas Muhammadiyah Surakarta, Indonesia
Sri Wahyuni
Medical faculty of Universitas Muhammadiyah Surakarta, Indonesia

Abstract


Background: Nigella sativa is reported to have an antioxidant effect, so allegedly has anti-diabetic effect. Objectives:The aim of this study is to explore ethyl acetate fraction of ethanol extract of Nigela sativa Linn. (EANS) effect toward blood glucose level in diabetic rats induced by alloxan. Materials and Methods: Twenty five male rats (150–200 g). The rats were divided into five groups in which there were 5 rats in each group. Group I was treated by glibenclamide 0.63 mg/kg bw (positive control); Group II was treated by aqueous 2,5 ml/200 g bw (negative control); and Groups III; IV and V were treated by ethyl acetate of ethanol extract of N. sativa seed at a dosage of 250 mg/kg bw; 500 mg/kg bw and 1000mg/kg bw respectively. Results: The results of this study are EANS can reduced blood glucose level on diabetic rats induced by alloxan. Nigella sativa has potencies anti-diabetic effect. Conclusion: Nigella sativa Linn. seed has potency as anti-diabetic candidate.

Keywords


Nigella sativa, anti-diabetic, ethyl acetate.

References