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Protective Effect of Colocasia Esculenta on Tnbs Induced Ulcerative Colitis in Mice


Affiliations
1 Assistant Professor, Jakir Hossain Institute of Pharmacy, Miapur, Murshidabad,742225., India
2 Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India
3 Assistant Professor, School or pharmacy, Techno India University, Salt Lake, Kolkata-700091, W.B., India
     

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Objective: Ulcerative colitis (UC) is a recurrent ulceroinflammatory disease that is mainly restricted to colonic mucosa with variable colonic architecture distortion. Different types of drugs are used for management of UC namely Salfasalazine, Balsalazide, Mesalamine etc. However, they are associated with different types of adverse effects such as nausea, vomiting, skin rash, headache. Hence, we narrowed in on Colocasia esculenta and its available in India, Bangladesh, Pakistan. In our present study the anticolitic effects Colocasia esculenta in treatment the TNBS induced model for UC in mice were examined. Methods: Male mice, 7 weeks of age, are selected. They are divided into various categories:Negative control groups treated with normal saline solution ,positive control group treated with TNBS5%, standard group treated with Balsalazide 4mg/kg & TNBS 5% , Test(1) group treated with Colocasia esculenta 100mg/kg, Test(2) group treated with Colocasia esculenta 150 mg/kg, Test(3) group treated with Colocasia esculenta 250 mg/kg then we were performed various parameters such as DAI, Oxidative damage assessment, MPO Assessment. Results: The results have been showed that Colocasia esculenta has significant activity against TNBS (5%) induced colitis when compared to the experimental control, with near normalization of colon architecture. Tissue oxidative stress was reduced with significant improvement in tissue levels of MDA &GSH. Furthermore, significant improvement in levels of myeloperoxidase (MPO) was observed. Conclusion: It is concluded that Colocasia esculenta(250mg/kg) has got potent activity against TNBS (5%) induced ulcerative colitis (UC) due to its anti-inflammatory& antioxidant properties.

Keywords

Ulcerative colitis, Anti-inflammatory, Antioxidant, Colocasia esculenta, Myeloperoxidase.
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  • Protective Effect of Colocasia Esculenta on Tnbs Induced Ulcerative Colitis in Mice

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Authors

Srikanta Chandra
Assistant Professor, Jakir Hossain Institute of Pharmacy, Miapur, Murshidabad,742225., India
Tathagata Roy
Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India
Preeta Bose
Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India
Somsubhra Ghosh
Assistant Professor, School or pharmacy, Techno India University, Salt Lake, Kolkata-700091, W.B., India
Susanta Paul
Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India
Victor roychowdhury
Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India
Anannya Bose
Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India
Ankita Acharya
Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109., India

Abstract


Objective: Ulcerative colitis (UC) is a recurrent ulceroinflammatory disease that is mainly restricted to colonic mucosa with variable colonic architecture distortion. Different types of drugs are used for management of UC namely Salfasalazine, Balsalazide, Mesalamine etc. However, they are associated with different types of adverse effects such as nausea, vomiting, skin rash, headache. Hence, we narrowed in on Colocasia esculenta and its available in India, Bangladesh, Pakistan. In our present study the anticolitic effects Colocasia esculenta in treatment the TNBS induced model for UC in mice were examined. Methods: Male mice, 7 weeks of age, are selected. They are divided into various categories:Negative control groups treated with normal saline solution ,positive control group treated with TNBS5%, standard group treated with Balsalazide 4mg/kg & TNBS 5% , Test(1) group treated with Colocasia esculenta 100mg/kg, Test(2) group treated with Colocasia esculenta 150 mg/kg, Test(3) group treated with Colocasia esculenta 250 mg/kg then we were performed various parameters such as DAI, Oxidative damage assessment, MPO Assessment. Results: The results have been showed that Colocasia esculenta has significant activity against TNBS (5%) induced colitis when compared to the experimental control, with near normalization of colon architecture. Tissue oxidative stress was reduced with significant improvement in tissue levels of MDA &GSH. Furthermore, significant improvement in levels of myeloperoxidase (MPO) was observed. Conclusion: It is concluded that Colocasia esculenta(250mg/kg) has got potent activity against TNBS (5%) induced ulcerative colitis (UC) due to its anti-inflammatory& antioxidant properties.

Keywords


Ulcerative colitis, Anti-inflammatory, Antioxidant, Colocasia esculenta, Myeloperoxidase.

References