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A Brief Review on Pregnancy Risk Reasoned to Covid-19
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Introduction: Pregnancy is confronted with increased risk for COVID-19 since the expression of immune markers, realized the fact that the immune cells and cytokines, the virtuous understanding of the pathophysiology of the disease reduce maternal deaths. Pregnant women are enfeebled against the immune systems and are at added risk of contracting COVID-19. Indeed, they are at added risk of contracting COVID-19. The studies have proven the similarities between the COVID-19 and pregnancy regard to their immune system marked by a noticeable reduction in lymphocytes and raise in selected proinflammatory cytokines. Purpose: The study aims to conduct a review engine to enhance the knowledge on pathophysiological stirrings of condition in normal pregnancy and COVID-19, which are marked by decreased lymphocytes, NKG2A inhibitory receptors, and increased ACE2, IL-8, IL-10, and IP-10 project the risk for developing COVID-19 in pregnancy. To bring out the awareness on pregnancy vulnerability risk for COVID-19 and its complications. Method: This study is initiated with search engine reviewing previous studies correlating with various aspects of normal pregnancy COVID-19 pathophysiological aspects and COVID attack risk in pregnancy. This study probe through electronic databases such as PubMed, Medline, and Scopus databases using keywords such as Coronavirus Immune marker, Pregnancy Lymphocytes, Natural killer cells, a similar pat physiological condition in pregnancy, and COVID-19, Pregnancy vulnerability risk for COVID-19. Result: Analysed studies have given out fruitful information on pregnancy risk, the corona virus immune markers in pregnancy is seen with reduced lymphocytes, and increase proinflammatory cytokines that depict the similarity in the pathophysiological condition in pregnancy and COVID-19, pave up to pregnancy vulnerability for risk in COVID-19 contraction. Conclusion: This review analysis drawn informative tips for professionals that would be useful in educating patient as a part of preventive measure.
Keywords
Corona virus Immune markers Pregnancy Lymphocytes Natural killer cells, similar pathophysiological condition in pregnancy and COVID-19, Pregnancy vulnerability risk for COVID-19.
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- Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P. A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine. 2020 Jan 24.
- Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020 Feb 22; 395(10224):565-74.
- Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, Critchley HOD. Pregnancy and COVID-19. Physiol Rev. 2021 Jan 1; 101(1):303-318.
- World Health Organization. Definition and categorization of the timing of mother-to-child transmission of SARS-CoV-2: scientific brief, 8 February 2021. World Health Organization; 2021.
- Kopel J, Perisetti A, Roghani A, Aziz M, Gajendran M, Goyal H. Racial and gender-based differences in COVID-19. Frontiers in Public Health. 2020 Jul 28; 8:418.
- Lee K. The World Health Organization (WHO). Routledge; 2008 Aug 21. 7. Wang CL. Impact of COVID-19 on Pregnancy. International Journal of Medical Sciences. 2021; 18(3):763.
- Beigi RH, Krubiner C, Jamieson DJ, Lyerly AD, Hughes B, Riley L, Faden R, Karron R. The need for inclusion of pregnant women in COVID-19 vaccine trials. Vaccine. 2021 Feb 5; 39(6):868.
- Phoswa WN, Khaliq OP. Is pregnancy a risk factor of COVID-19? European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020 Sep 1; 252:605-9.
- Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061–1069.
- Li Q., Guan X., Wu P., Wang X., Zhou L., Tong Y. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N Engl J Med. 2020; 382:1199–1207.
- Ren L.-L., Wang Y.-M., Wu Z.-Q., Xiang Z.-C., Guo L., Xu T. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J. 2020; 133(9):1015–1024.
- Wang W., Tang J., Wei F. Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China. J Med Virol. 2020; 92(4):441–447.
- Carlos W.G., Dela Cruz C.S., Cao B., Pasnick S., Jamil S. Novel Wuhan (2019-nCoV) coronavirus. Am J Respir Crit Care Med. 2020; 201(4):P7–P8.
- Huang C., Wang Y., Li X., Ren L., Zhao J., and Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497–506.
- Goldstein B., Trivedi M., Speth R.C. Alterations in gene expression of components of the renin-Angiotensin system and its related enzymes in lung cancer. Lung Cancer Int. 2017; 2017
- Aung M., Konoshita T., Moodley J., Gathiram P. Association of gene polymorphisms of four components of renin-angiotensin-aldosterone system and preeclampsia in South African black women. Eur J Obstet Gynecol Reprod Biol. 2017; 215:180–187.
- Ghadhanfar E., Alsalem A., Al-Kandari S., Naser J., Babiker F., Al-Bader M. The role of ACE2, angiotensin-(1–7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction. Reprod Biol Endocrinol. 2017; 15(1):97. 19.
- Li M., Chen L., Zhang J., Xiong C., Li X. The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS One. 2020; 15(4)
- Favre G., Pomar L., Musso D., Baud D. 2019-nCoV epidemic: what about pregnancies? Lancet (Lond Engl) 2020; 395(10224):e40.
- Turco M.Y., Moffett A. Development of the human placenta. Development. 2019; 146(22)
- Li M., Chen L., Zhang J., Xiong C., Li X. The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS One. 2020; 15(4)
- Phoswa WN, Khaliq OP. Is pregnancy a risk factor of COVID-19? European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020 Sep 1; 252:605-9.
- Villar J, et al., Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatrics. 2021 Apr 22.
- RCOG. COVID-19 virus infection and pregnancy. Occupational health advice for employers and pregnant women during the COVID-19 pandemic. Royal College of Obstetrics and Gynaecology, United Kingdom, 2020.
- Dashraath P, Wong JL, Lim MX, Lim LM, Li S, Biswas A, Choolani M, Mattar C, Su LL. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. American Journal of Obstetrics and Gynecology. 2020 Jun 1; 222(6):521-31.
- Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, Vecchiet J, Nappi L, Scambia G, Berghella V, D’Antonio F. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. American Journal of Obstetrics and Gynecology MFM. 2020 May 1; 2(2):100107.
- Iqbal SN, Overcash R, Mokhtari N, Saeed H, Gold S, Auguste T, Mirza MU, Ruiz ME, Chahine JJ, Waga M, Wortmann G. An uncomplicated delivery in a patient with Covid-19 in the United States. New England Journal of Medicine. 2020 Apr 16; 382(16):e34.
- Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009; 114: 1326- 1331.
- Zeidler C, Grote UA, Nickel A, et al. Outcome and management of pregnancies in severe chronic neutropenia patients by the European branch of the severe chronic neutropenia international registry. Haematological. 2014; 99: 1395- 1402.
- Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstetrics and Gynecology. 2009 Dec 1; 114(6):1326-31.
- Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID‐19. Journal of Thrombosis and Haemostasis. 2020 Sep; 18(9):2103-9.
- Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, Clark C, Iba T. ISTH interim guidance on recognition and management of coagulopathy in COVID‐19. Journal of Thrombosis and Haemostasis. 2020 May; 18(5):1023-6.
- Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020 Feb 15; 395(10223):497-506.
- Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395: 809- 815.
- Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, Clark C, Iba T. ISTH interim guidance on recognition and management of coagulopathy in COVID‐19. Journal of Thrombosis and Haemostasis. 2020 May; 18(5):1023-6.
- Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, Wang Q, Miao H. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduction and Targeted Therapy. 2020 Mar 27; 5(1):1-3.
- Tan L, Wang Q, Zhang D, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduction and Targeted Therapy. 2020; 5: 33.
- Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. The Lancet Gastroenterology and Hepatology. 2020 May 1; 5(5):428-30.
- Chen Y, Liu Q, Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. Journal of Medical Virology. 2020 Apr; 92(4):418-23.
- Wan Y., Shang J., Graham R., Baric R.S., Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Viral. 2020; 94(7)
- Shereen M.A., Khan S., Kazmi A., Bashir N., Siddique R. COVID-19 infection: origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020; 24:91–98.
- Hanna J. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nature Medicine. 2006 Sep; 12(9):1065-74.43.
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