Research Journal of Pharmacy and Technology

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Recent Trends in Floating Drug Delivery System


Affiliations
1 Department of Pharmacy, (B R Nahata College of Pharmacy), Mandsaur University, Rewas Dewda Road, SH - 31, Mandsaur, Madhya Pradesh- 458001., India
     

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Conventional immediate release dosage forms does not control the drug release which leads to low oral bioavailability and more toxic effects. This happens due to multiple dosing and fluctuations in the plasma drug concentrations. Retention of the dosage forms in a specific region of the GIT provides more benefits, for those drugs which have poor absorption in stomach, low solubility and degradation in alkaline pH. FDDS is one among the important system with gastric retention properties. Formulations designed as FDDS, controls the rate of drug release by prolonging the gastric retention for extended hours and improves the absorption as well as bioavailability. This article provides information on recent trends of research and development in FDDS with a special emphasis on its importance for oral controlled drug delivery system. This review article also provides information on category of drugs and different polymers used for FDDS.

Keywords

Floating, Gastro Retention, In-vitro and In-vivo evaluation, Polymers, Controlled Release.
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  • Narang N: An updated review on floating drug delivery system (FDDS). International Journal of Applied Pharmaceutics. 3 (1); 2011: 1-2.

  • ShwetaArora et al, Floating Drug Delivery Systems- A Review, AAPS PharmSciTech 2005; 6 (3) Article 47

  • Moursy NM et al, Formulation and evaluation of sustained release floating capsules of Nicardipine hydrochloride. Pharmazie. 2003;58:38Y43. 4. Erni W and Held K: The hydrodynamically balanced system-a novel principle of controlled drug release. Eur Neurol. 1987;27:215Y275.

  • Menon A, Ritschel WA and Sakr A: Development and evaluation of a monolithic floating dosage form for furosemide. J Pharm Sci. 1994; 83:239Y245.

  • Oth M, Franz M, Timmermans J and Moes A: The bilayer floating capsule: a stomach directed drug delivery system for misoprostal. Pharm Res. 1992;9:298Y302.

  • HetangiRathod, Vishnu Patel and MoinModasia: Floating Drug Delivery System: Innovative Approach Of Gastroretention, International Journal of Pharmaceutical Sciences Review and Research, Volume 4, Issue 3, September – October 2010; Article 030

  • Wilson CG and Washington N: Physiological Pharmaceutics: Biological Barriers to Drug Absorption, Horwood Ellis, Chichester, 1989; 47-70.

  • Groning R and Heun G: Oral dosage forms with controlled gastrointestinal transit. Drug DevInd Pharm. 1984; 10: 527-539.

  • Deshpande AA et al, Development of a novel controlled release system for gastric retention, Pharm. Res. 1997; 14: 815-819.

  • Kawashinia Y et al, Hallow microspheres for use as a floating controlled drug delivery system in the stomach. J.Pharm. Sci.1992; 81(2): 135-140.

  • Bechgaard H and Ladefoged K: Distribution of pellets in the gastrointestinal tract: The influence on transit time exerted by density or diameter of pellets. J.Pharm. Pharmacol. 1978; 30:690-692.

  • Davis SS et al, The effect on density on the gastric emptying of Single and multiple-unit dosage form. Pharm.Res.1986; 3:208-213.

  • Ponchel G and Irache JM: Specific and nonspecific bioadhesive particulate system for Oral delivery to the gastrointestinal tract. Adv.Drug.Del.Rev.1998;34:191-219

  • Klausner EA et al, Expandable gastroretentive dosage forms. J Control Release. 2003; 90:143-162.

  • KaushikAvinash et al, “Floating Drug Delivery System a Significant Tool for Stomach Specific Release of Cardiovascular Drugs” Int. J. Drug Dev. and Res., October-December 2012, 4(4): 116-129.

  • Pooja Gupta, Gnanarajan and PreetiKothiyal: Floating Drug Delivery System: A Review, International Journal of Pharma Research and Review, August 2015; 4(8):37-44

  • Chikhalikar SS and Wakade RB: Floating Drug Delivery System – An Approach To Oral Controlled Drug Delivery, International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.4, No.4, pp 1812-1826, Oct-Dec 2012

  • Kumar D et al, “Approaches, techniques and Evaluation of Gastroretentive Drug Delivey systems: an overview.” International Journal of Research in Ayurveda and Pharmacy.2(3),2011 767-774

  • Vinod KR et al, “Approaches for gastrotentive drug delivery systems.”International Journal of Applied Biology and Pharmaceutical Technology Page: 589-601

  • NayakAmitKuma, MajiRuma and Das Biswarup: “Gastroretentive drug delivery systemsreview.” Asian Journal of Pharmaceutical and Clinical ResearchVol.3 Issue 1, January- March 2010 P.No..2-10

  • ChawlaGarima et al, “Gastroretention A Means to Address Regional Variability in Intestinal Drug Absorption.” Pharmaceutical Technology JULY 2003 P.No.50-68

  • GurnanyEkta et al, “Gastro Retentive Drug Delivery System- AReview.”Journal of Pharmacy Research Vol.4.Issue 6. June 2011,4(6),1899-1908

  • Brahma N. Singh and Kwon H. Kim: Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled Release 63 (2000) 235–259.

  • M Sharath Chandra Goud and V P Pandey: Gastroretentive Drug Delivery System, International Journal of Pharmacy and Biological Sciences ISSN: 2321-3272 (Print), ISSN: 2230-7605 (Online) IJPBS | Volume 6 | Issue 3| JUL-SEP | 2016 | 158-165

  • Sato Y et al, In-vitro evaluation of floating and drug releasing behavior of hollow microspheres (microballons) prepared by emulsion solvent diffusion method Eur J Pharm Biopharm2004 ; 57(2), 235-243. 27. Prajapati ST, Patel LD and Patel CN: Polymers for Floating Drug Delivery System, Systematic Reviews in Pharmacy | January-June 2011 | Vol 2 | Issue 1

  • Singh Amit Kumar, DubeyVivek and AroraVandana: Role of Natural Polymers used in Floating Drug Delivery System, Journal of Pharmaceutical and Scientific Innovation.

  • Azhar Danish Khan and MeenakshiBajpai: Floating Drug Delivery System: An Overview, International Journal of PharmTech Research, CODEN (USA): IJPRIF ISSN : 0974-4304, Vol.2, No.4, pp 2497-2505, Oct-Dec 2010

  • Patel VF and Patel NM: Intragastric floating drug delivery system of Cefuroxime Axetil : In vitro Evaluation AAPS Pharm Sci Tech 2006 ;7(1) , P.No. E1-E7

  • Shoufeng Li and Senshang Lin: Statistical optimisation of gastric floating system for oral controlled delivery of Calcium AAPS Pharm Sci Tech , 2001 , 2(1)

  • Anand Patel and MoinModasiya: Development and in vivo floating behavior of Verapamil hydrochloride Intragastric Floating Tablets, AAPS PharmSci Tech, 2009,Vol 10. No.1,

  • Desai S and Bolton S: A floating controlled release drug delivery system: in vitro- in vivo evaluation , Pharm Research 1993 ;10, 1321- 1325

  • ElmowafyEnas M and AwadGehanneAS: Ionotropically gelled polysaccharides beads : preparation and in vitro and in vivo evaluation; Carbohydrate Polymers 2009; Vol 75 , 135-142

  • Patel LYagnesh, Sher Praveen and PawarAtmaram: The effect of Drug concentration and curing time on processing and properties of calcium alginate beads containing Metronidazole by response surface methodology AAPS Pharm Sci Tech 2006; 7(4), E1-E7

  • Roy Pallabh and Ali Asgar: Multiparticulate formulation approach to pulsatile drug delivery : Current Perspectives ,J. Controlled Release , 2009;13474-80

  • NathBipul, Nath LK and Mazumdar B: Preparation and in vitro evaluation of gastric floating microcapsules of Metformin HCL; Indian Journal of Pharmaceutical Education and Research 2009;43(2), 177-185

  • Pravin N Ghule, Amol S Deshmukh and Vijay R Mahajan: Floating Drug Delivery System (FDDS): An Overview. Research Journal of Pharmaceutical Dosage Forms and Technology. 6(3): July- September, 2014, 174-182

  • SrujanaKatta, Mettu Srikanth Reddy and N. G. RaghavendraRao: Overview On Floating Drug Delivery System, Am. J. PharmTech Res. 2013; 3(2) ISSN: 2249-3387.

  • Sriamornsak P, Thirawong N and Puttipipatkhachorn S: Morphology and buoyancy of oil-entrapped calcium pectinate gel beads. The AAPS Journal. 2004;6:E24.

  • Girish S. Sonar and D.K. Jain: Prepatation and in vitro Evaluation of bilayer and floating –bioadhesive tablet of Rosiglitazone Maleate, Asian Journal of Pharmaceutical Sciences 2004; 1(4) ,161-169.

  • Rajesh Kaza and E Usharani: Design and evaluation of sustained release floating tablet for the treatement of gastric ulcers , J Pharm Sci and Res 2009 ;1(4) :81-87.

  • Nur AO and Zhan JS: Captopril floating and / or bioadhesivetablets , Drug Develop Ind Pharm 2000;26(9):,965-9.

  • Li S et al, Statistical optimization of gastric floating system for oral controlled delivery of calcium. AAPS PharmSciTech. 2001;2:E1.

  • Sato Y and Kawashima Y: In vitro and in vivo evaluation of riboflavin containing microballoons for a floating controlled drug delivery system in healthy human volunteers. J Control Release. 2003;93: 39Y47.

  • Ichikawa M, Watanabe S and Miyake Y: A new multiple unit oral floating dosage system. I: Prepration and in vitro evaluation of floating and sustained-release kinetics. J Pharm Sci. 1991;80:1062Y1066.

  • Timmermans J and Andre JM: Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: new data for reconsidering the controversy. J Pharm Sci. 1994;83:18Y24.

  • MukeshGohel et al, A More Relevant Dissolution Method for Evaluation of Floating Drug Delivery System January 2004 Dissolution Technologies 11(4).

  • Miyazaki S et al, Sustained release of indomethacin from chitosan granules. Chem. Pharm. Bull. 33, 3986-3992.

  • Ashok A. Hazare and Vrushali A. Patil: Formulation and Characterization of Metformin Hydrochloride Floating Tablets. Asian J. Pharma. Res. 2(3): 2012: 111-117.

  • Pramod Patil et al, Formulation and In Vitro Evaluation of Floating Matrix Tablets of Ofloxacin. Asian J. Res. Pharm. Sci. 1(1): 2011: 17-22.

  • Salve P. S., Effect of Excipient and processing parameters on floating characteristics of hydrodynamically balanced system for diltiazem hydrochloride. Asian J. Res. Pharma. Sci. 1(4): 2011: 97-99.

  • Nirav Patel, Jinal Patel and Moin Modasiya: Formulation and Evaluation of Glipizide as Floating Drug Delivery System. Asian J. Pharma. Tech 2(2): 2012: 67-73.

  • Manish P Patel et al, Designing and Evaluation of Floating Microspheres of Verapamil Hydrochloride: Effect of Methocel. Research Journal of Pharmaceutical Dosage Forms and Technology. 1(1): 2009: 22-28.

  • Dinesh I Dhamecha et al, Development and In Vitro Evaluation of Oral Floating Matrix Tablet Formulation of Ranitidine Hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology. 1(1): 2009: 41-44.

  • Prakash N Kendre et al, Formulation and In Vitro - In Vivo Evaluation of Alfuzosin Hydrochloride Floating Matrix Tablets. Research Journal of Pharmaceutical Dosage Forms and Technology. 1(2): 2009: 119-125.

  • Prakash N Kendre et al, Oral Sustained Delivery of Rosiglitazone Maleate Floating Matrix Tablets – Formulation and In Vitro Evaluation. Research Journal of Pharmaceutical Dosage Forms and Technology. 1(3): 2009: 257-262.

  • SM Sarode et al, Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2(2): 2010: 173-177.

  • YS Gattani, PS Kawtikwar and DM Sakarkar, Preparation and Evaluation of Tramadol Hydrochloride Floating Oral Delivery System. Research J. Pharma. and Tech. 1(13): 2008: 171-174.

  • Pare A, Yadav SK and Patil UK, Formulation and Evaluation of Floating Tablet of Amlodipine besylate. Research J. Pharma. and Tech. 1(14): 2008: 526-530.

  • AV Mayavanshi and SS Gajjar, Floating drug delivery systems to increase gastric retention of drugs: A Review. Research J. Pharma. and Tech. 1(4): 2008: 345-348.


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  • Recent Trends in Floating Drug Delivery System

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Authors

D R Parida
Department of Pharmacy, (B R Nahata College of Pharmacy), Mandsaur University, Rewas Dewda Road, SH - 31, Mandsaur, Madhya Pradesh- 458001., India
A A Kharia,
Department of Pharmacy, (B R Nahata College of Pharmacy), Mandsaur University, Rewas Dewda Road, SH - 31, Mandsaur, Madhya Pradesh- 458001., India
N K Choudhary
Department of Pharmacy, (B R Nahata College of Pharmacy), Mandsaur University, Rewas Dewda Road, SH - 31, Mandsaur, Madhya Pradesh- 458001., India

Abstract


Conventional immediate release dosage forms does not control the drug release which leads to low oral bioavailability and more toxic effects. This happens due to multiple dosing and fluctuations in the plasma drug concentrations. Retention of the dosage forms in a specific region of the GIT provides more benefits, for those drugs which have poor absorption in stomach, low solubility and degradation in alkaline pH. FDDS is one among the important system with gastric retention properties. Formulations designed as FDDS, controls the rate of drug release by prolonging the gastric retention for extended hours and improves the absorption as well as bioavailability. This article provides information on recent trends of research and development in FDDS with a special emphasis on its importance for oral controlled drug delivery system. This review article also provides information on category of drugs and different polymers used for FDDS.

Keywords


Floating, Gastro Retention, In-vitro and In-vivo evaluation, Polymers, Controlled Release.

References