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Pharmacokinetic and Pharmacodynamic Studies of Omeprazole Co-crystals Dry Suspension


Affiliations
1 Department of Pharmaceutics, Rao’s College of Pharmacy, Nellore, Andhra Pradesh,, India
2 Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati- 517502, Andhra Pradesh,, India
     

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A novel omeprazole co-crystals instant dry suspension dosage was formulated by applying co-crystallization which is a particle engineering technique to enhance the physicochemical properties. As omeprazole has major critical draw backs in their solubility and stability (acidic pH degradation, thermal sensitivity, photosensitivity and highly hygroscopic nature) bioavailability of omeprazole was drastically reduced and purpose of administration of drug was not fulfilled. There by this formulation was invented to check maid these problems. In this present study in-vivo evaluation were performed. Pharmacokinetic parameters and pharmacodynamic parameters were determined and statistically analysed. The prepared formulation of omeprazole produced reliable satisfaction in solving the drawback problems of pure omeprazole by enhancing bioavailability. Statistical analysis was done by one way ANOVA test with P value less than 0.0001, Dunnet multiple comparison test was performed between the groups with P value < 0.01 which was considered to be significant.

Keywords

Omeprazole co-crystals, pharmacokinetic parameters, pharmacodynamic studies and ulcer index.
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  • Pharmacokinetic and Pharmacodynamic Studies of Omeprazole Co-crystals Dry Suspension

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Authors

Madhuri Gaddam
Department of Pharmaceutics, Rao’s College of Pharmacy, Nellore, Andhra Pradesh,, India
Nagaraju Ravouru
Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati- 517502, Andhra Pradesh,, India

Abstract


A novel omeprazole co-crystals instant dry suspension dosage was formulated by applying co-crystallization which is a particle engineering technique to enhance the physicochemical properties. As omeprazole has major critical draw backs in their solubility and stability (acidic pH degradation, thermal sensitivity, photosensitivity and highly hygroscopic nature) bioavailability of omeprazole was drastically reduced and purpose of administration of drug was not fulfilled. There by this formulation was invented to check maid these problems. In this present study in-vivo evaluation were performed. Pharmacokinetic parameters and pharmacodynamic parameters were determined and statistically analysed. The prepared formulation of omeprazole produced reliable satisfaction in solving the drawback problems of pure omeprazole by enhancing bioavailability. Statistical analysis was done by one way ANOVA test with P value less than 0.0001, Dunnet multiple comparison test was performed between the groups with P value < 0.01 which was considered to be significant.

Keywords


Omeprazole co-crystals, pharmacokinetic parameters, pharmacodynamic studies and ulcer index.

References