Evaluation of Toxicity and Antidiabetic Activity of Ethanolic Extract of Flowers of Moringa Oleifera Against Dexamethasone Induced Hyperglycemia in Albino Wistar Rats

Diabetes is a defect in the ability of the body to convert glucose (sugar) to energy. Glucose is the main source of energy in our body. When food is digested it is metabolized into fats, proteins, or carbohydrates. Glucose is then transferred to the blood and is used by the cells for energy production. To investigate the antidiabetic effect ethanolic extracts of flowers of Moringa oleifera against dexamethasone-induced insulin resistance in wistar albino rats. To study the antidiabetic effect, flowers of Moringa oleifera were collected and authenticated, extracted and investigated for acute toxicity and dexamethasone induced hyperglcemia. The animals treated with EEMOF at a dose of 100mg/kg and 200mg/kg prevented the development of hyperglycemia, hypercholesteremia and hypertriglyceridemia in dexamethasone induced insulin resistance models. Oral administration of Moringa oleifera 100mg/kg and 200mg/kg reduces serum glucose, triglyceride, total cholesterols and LDL concentration and improve the concentration of HDL in dexamethasone administered rats. The lignin Moringa oleifera showed significant anti-diabetic effect in rats after oral administration. The present study demonstrated that Moringa oleifera could be useful in Management of diabetes associated with abnormalities in lipid profiles. Further study need to isolate, identify the active compounds and find out the possible mechanism of actions.