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Green Solvent Assisted Uv-spectrophotometric Method for Estimation of Rosuvastatin in Bulk and Pharmaceutical Dosage Forms
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Objectives: The goal of this study is to create and test a UV-Spectrophotometric method for estimating Rosuvastatin in bulk and pharmaceutical dosage forms utilizing a green solvent. Method: Development of UV-Spectrophotometric method was carried out by using 2% Sodium Lauryl Sulfate solution as green solvent. Rosuvastatin was detected at a wavelength of 242nm. According to ICH guidelines, the developed technique was verified in terms of linearity, precision, repeatability, limit of detection, limit of quantification, accuracy, and robustness. Rosuvastatin in pharmaceutical dose forms was successfully estimated using a newly developed and verified approach. Results: Rosuvastatin has a maximum absorption wavelength of 242nm. In the concentration range of 5-25μg/ml, Beer's law was followed. The detection and quantification limits were found to be 1.58μg/ml and 4.79μg/ml, respectively. The recovery of Rosuvastatin Calcium in tablet form was found to be between 97 and 102 percent. All of the precision and repeatability results fell within acceptable limits. Rosuvastatin was tested and found to be 98.88%. Conclusion: The method was found to be simple, environment friendly, reproducible and economical and can be used for routine analysis of Rosuvastatin in bulk and pharmaceutical dosage form. The 2% Sodium Lauryl Sulfate solution can be used as Green solvent.
Keywords
Rosuvastatin, Sodium Lauryl Sulfate, Green Solvent, Validation, Beer’s law.
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