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Investigation of Wrightia Tinctoria Extract Activity on Alopecia Using In-silco And In-vivo Studies


Affiliations
1 Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh,, India
2 Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, India
3 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
     

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There are many drugs for alopecia such as minoxidil, glucocorticoids, sulfasalazine, nitric oxide, and vitamin D3. Hair loss is also known as alopecia, or baldness commonly refers to hair loss from either a portion of a head or body. Fresh Leaves, and bark from twigs of Wrightia tinctoria were taken and used for extraction. A phytochemical assessment was continued to carry out on W.tinctoria extract and the presence of aromatic hydrogen and aromatic protons was demonstrated by spectral characterization. Insilco studies were done. Compounds 1and6 shown more docking values than the minoxidil and Swiss ADME confirmed that the compounds can enter the blood-brain barrier and not the substrates of PgP carriers. In vivo evaluation of alopecia activity using albino male, Wistar rats were done by comparing it with standard drug involves the evaluation of in vivo hair development activities of W.tinctoria extract. It also involves histopathological studies which include the action of hair growth at anagen and telogen phases on 15th and 30th day. The study indicates that the material elements of W.tinctoria which include Quercetin and Indirubin playing a critical role in hair promoting activity.

Keywords

Wrightia tinctoria, Alopecia, Coconut oil, Minoxidil, Anagen phase, Telogen phase.
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  • Investigation of Wrightia Tinctoria Extract Activity on Alopecia Using In-silco And In-vivo Studies

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Authors

K. Sruthi
Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh,, India
B. Anupama
Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, India
N. L. Sudeepthi
Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, India
P. Gopi Krishna
Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, India
Abdul Kareem
Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, India
Mohammad Habeeb
Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India

Abstract


There are many drugs for alopecia such as minoxidil, glucocorticoids, sulfasalazine, nitric oxide, and vitamin D3. Hair loss is also known as alopecia, or baldness commonly refers to hair loss from either a portion of a head or body. Fresh Leaves, and bark from twigs of Wrightia tinctoria were taken and used for extraction. A phytochemical assessment was continued to carry out on W.tinctoria extract and the presence of aromatic hydrogen and aromatic protons was demonstrated by spectral characterization. Insilco studies were done. Compounds 1and6 shown more docking values than the minoxidil and Swiss ADME confirmed that the compounds can enter the blood-brain barrier and not the substrates of PgP carriers. In vivo evaluation of alopecia activity using albino male, Wistar rats were done by comparing it with standard drug involves the evaluation of in vivo hair development activities of W.tinctoria extract. It also involves histopathological studies which include the action of hair growth at anagen and telogen phases on 15th and 30th day. The study indicates that the material elements of W.tinctoria which include Quercetin and Indirubin playing a critical role in hair promoting activity.

Keywords


Wrightia tinctoria, Alopecia, Coconut oil, Minoxidil, Anagen phase, Telogen phase.

References