Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and Evaluation of Emulgel for Topical Delivery of Dexibuprofen


Affiliations
1 Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
     

   Subscribe/Renew Journal


An emulgel formulation was developed for a topical non-steroidal anti-inflammatory agent using carbopol as the gelling agent. The effect of concentrations of oil, surfactant and gelling agent on the in-vitro drug release pattern was investigated using 23 factorial design. The optimized emulgel formulations were characterized for appearance, color, pH, homogeneity, viscosity and spreadability. The in-vitro release profile drug from the emulgel formulation was strongly affected by the concentration of gelling agent, surfactants and oil. Stability studies were conducted at different temperatures and humidity conditions that indicated the formulations to be stable under accelerated conditions. No erythema or irritation was observed during the skin irritation studies on rabbits. Optimized formulation showed comparable analgesic and anti-inflammatory activity when they compared with marketed Nurofen gel. So, it can be concluded that topical emulgel of dexibuprofen posses an effective anti-inflammatory and analgesic activity.

Keywords

Dexibuprofen, Topical drug delivery, Anti-inflammatory, Analgesic, NASAIDs.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Bhaskaran S, Harsha NS. Effect of permeation enhancers and iontophoresis on permeation of atenolol from transdermal gels. Ind J Pharm Sci. 2000; 6:424-426.

  • Brown MB, Martin GP, Jones SA, Akomeah FK., Dermal and transdermal drug delivery systems: current and future prospects. J. European Acad. Dermatol. Venerology, 2006; 13:175-187.

  • Giannakou SA, Dallas PP, Rekkas DM, Choulis NH. , Development and in vitro evaluation of nitrendipine transdermal formulations using experimental design. Int J Pharm Tech. 1995; 125:7-15.

  • Kumar R, Philip A. , Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin. Trop J Pharm Res. 2007; 6:633-644.

  • J. Hadgraft, C. Valenta, pH, pKa and dermal delivery, Int. J. Pharm, 2000; 243-247.

  • Emulsions and Creams. In: Dispensing for Pharmaceutical Students, 12th Edition, Ed Carter S J, Kent, England: Pitman Medical, 1975; 120-166.

  • Eswaraiah S., Swetha K., Lohita M., P. Jaya Preethi, B. Priyanka, Kiran Kumar Reddy. Emulgel: Review on Novel Approach to Topical Drug Delivery. Asian J. Pharm. Res. 4(1): Jan.-Mar. 2014; 04-11.

  • Winfield A J. External Preparatoins. 3rd Edition, Eds Winfield A J, Richards R M E, New York: Churchill Livingstone, 2004; 206 – 217.

  • Anuradha A Sawant, S.K. Mohite. Formulation and Evaluation of Itraconazole Emulgel for Topical Drug Delivery. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 2, 91-96.

  • Mayuresh. R. Redkar, Priyajit S Hasabe, Suraj. T. Jadhav, Pankaj S Mane, Deepak J Kare. Review on Optimization base Emulgel Formulation. Asian J. Pharm. Tech. 2019; 9(3):228-237.

  • Kshama R. Phutane, Suvidha S. Patil, Rahul S. Adnaik, Manoj M. Nitalikar, Shrinivas K. Mohite, Chandrakant S. Magdum. Design and Development of Allopurinol Emulgel. Research J. Pharm. and Tech. 7(7): July 2014, 733-736.

  • Pratiksha V. Shrikhande. Formulation and Evaluation of Polyherbal Topical Anti-Inflammatory Emulgel. Research J. Pharm. and Tech. 6(1): Jan. 2013; 118-122.

  • Jayprakash. S. Suryawanshi, Shivaji. P. Gawade. Enhanced anti-arthritic effect of mustard oil in Nanoemulgel Formulation: A comparative clinical study. Research J. Pharm. and Tech. 2020; 13(8): 3738-3744.

  • Kumar Bandhu Lathiyare, Vishal Jain. Development and characterization of karanj oil based proniosomal gel for topical delivery. Research J. Pharm. and Tech. 7(9): Sept. 2014, 1052-1059.

  • Deepika John, R. Narayana Charyulu, Ravi G. S, Jobin Jose. Nanosponge Based Hydrogels of Etodolac for Topical Delivery. Research J. Pharm. and Tech. 2020; 13(8):3887-3892.

  • Simon G. A., Maibac Simon G. A., Maibach H. I. The pig as an experimental animal model of percutaneous permeation in man : qualitative and quantitative observations- an overview. Skin Pharmacol. Appl. Skin Physio.,2000; 13, 229-234.

  • Primary Skin Irritation Test in the Rabbit of Water Jel Burn Dressing. [Online]. 2007. [Cited 2007 September 13]. Available from: URL: http://www.waterjel.com/public/SkinIrritationTest.pdf

  • ICH Harmonized Tripartite Guideline Stability Testing of New Drug Substances and Products Q1A (R2). 2003.

  • K.G. Malviya, U.D. Shivhare, Preeti Srivastav, S.C. Shivhare. Evaluation of Analgesic potential of Cyathocline lyrata Cass Plant in Rats by using Tail Flick and Hot Plate Method. Asian J. Pharm. Res. 3(2): April- June 2013; 82-85.

  • H. Gerhard Vogel, Analgesic, Anti-inflammatory and Antipyretic activity. Drug Discovery and Evaluation. 2002; 670-773.

  • N. Kasliwal, D. Derle, J. Negi, J. Gohil. Effect of permeation enhancers on the release and permeation kinetics of meloxicam gel formulations through rat skin. Asian J. Pharm. Sci. 2008; 3 (5): 193–199.


Abstract Views: 83

PDF Views: 0




  • Formulation and Evaluation of Emulgel for Topical Delivery of Dexibuprofen

Abstract Views: 83  |  PDF Views: 0

Authors

Rina Maskare
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
Shital Thakre
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
Vithika Gupta
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
Manisha Basantwani
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
Ayush Kshirsagar
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
Triveni Bahekar
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India
Akash Jaiswal
Manoharbhai Patel Institute of B-Pharmacy, Kudwa, Gondia-441614, Maharashtra., India

Abstract


An emulgel formulation was developed for a topical non-steroidal anti-inflammatory agent using carbopol as the gelling agent. The effect of concentrations of oil, surfactant and gelling agent on the in-vitro drug release pattern was investigated using 23 factorial design. The optimized emulgel formulations were characterized for appearance, color, pH, homogeneity, viscosity and spreadability. The in-vitro release profile drug from the emulgel formulation was strongly affected by the concentration of gelling agent, surfactants and oil. Stability studies were conducted at different temperatures and humidity conditions that indicated the formulations to be stable under accelerated conditions. No erythema or irritation was observed during the skin irritation studies on rabbits. Optimized formulation showed comparable analgesic and anti-inflammatory activity when they compared with marketed Nurofen gel. So, it can be concluded that topical emulgel of dexibuprofen posses an effective anti-inflammatory and analgesic activity.

Keywords


Dexibuprofen, Topical drug delivery, Anti-inflammatory, Analgesic, NASAIDs.

References