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Fluctuations in Serum Magnesium and Systemic Arterial Blood Pressures During the Menstrual Cycle in Young Reproductive Women


Affiliations
1 Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia. 3Dental Association,, Myanmar
2 Department of Physiology, University of Medicine, Magway,, Myanmar
3 Faculty of Medicine and Health Sciences, University Malaysia Sarawak., Malaysia
4 Dental Association, Myanmar
     

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Introduction: The menstrual cycle involves a sequence of structural, functional, and hormonal changes in the reproductive system. This is linked and controlled by cyclical fluctuations in the levels of FSH, LH, estrogen, and progesterone. Because of these cyclical fluctuations, there might also be associated cyclical changes of magnesium and systemic arterial blood pressures during the menstrual cycle. Purpose: To assess the changes in serum magnesium level and systemic arterial blood pressures during the menstrual cycle in young reproductive women. Methodology: the sample population is 40 apparently healthy young reproductive-aged 18- 25years female students from the University of Medicine, Magway participated in this study. Systemic arterial blood pressures were measured by indirect method. The serum magnesium level was measured by spectrophotometry. These measurements were done in the early follicular phase (EF), the peri-ovulatory phase (PO), and the mid-luteal phase (ML) of the menstrual cycle. The serum magnesium levels were significantly (p <0.001) lower, and the systolic blood pressures were significantly higher (p <0.05) in the PO than the EF and the ML. In the EF, there was a significant negative correlation between serum magnesium level and diastolic blood pressure (r= -0.374, p <0.05) and mean arterial pressure (r = -0.354, p < 0.05) but no significant correlation with systolic blood pressure. In the PO, there was no significant correlation between serum magnesium level and systemic arterial blood pressures. In the ML, there was significant negative correlation between serum magnesium level and systolic blood pressure (r = -0.651, p <0.001), diastolic blood pressure (r = -0.607, p <0.001), and mean arterial pressure (r = -0.661, p <0.001). Conclusion: The study concludes that serum magnesium level has a negative effect on blood pressure changes and the blood pressure-lowering effect of magnesium. These changes are related to the fluctuation of estrogen levels during the menstrual cycle.


Keywords

Serum magnesium, systemic arterial blood pressures, menstrual cycle reproductive system.
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  • Fluctuations in Serum Magnesium and Systemic Arterial Blood Pressures During the Menstrual Cycle in Young Reproductive Women

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Authors

Mya Mya Thwin
Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia. 3Dental Association,, Myanmar
Pyae Phyo Maung
Department of Physiology, University of Medicine, Magway,, Myanmar
Htet Htet Oo
Department of Physiology, University of Medicine, Magway,, Myanmar
Mar Mar Lwin
Faculty of Medicine and Health Sciences, University Malaysia Sarawak., Malaysia
KhinThan Yee
Faculty of Medicine and Health Sciences, University Malaysia Sarawak., Malaysia
Ma Saung Oo
Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia. 3Dental Association,, Myanmar
Min Swe Zaw
Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia. 3Dental Association,, Myanmar
Minn Han
Dental Association, Myanmar
Soe Minn Htway
Department of Physiology, University of Medicine, Magway,, Myanmar

Abstract


Introduction: The menstrual cycle involves a sequence of structural, functional, and hormonal changes in the reproductive system. This is linked and controlled by cyclical fluctuations in the levels of FSH, LH, estrogen, and progesterone. Because of these cyclical fluctuations, there might also be associated cyclical changes of magnesium and systemic arterial blood pressures during the menstrual cycle. Purpose: To assess the changes in serum magnesium level and systemic arterial blood pressures during the menstrual cycle in young reproductive women. Methodology: the sample population is 40 apparently healthy young reproductive-aged 18- 25years female students from the University of Medicine, Magway participated in this study. Systemic arterial blood pressures were measured by indirect method. The serum magnesium level was measured by spectrophotometry. These measurements were done in the early follicular phase (EF), the peri-ovulatory phase (PO), and the mid-luteal phase (ML) of the menstrual cycle. The serum magnesium levels were significantly (p <0.001) lower, and the systolic blood pressures were significantly higher (p <0.05) in the PO than the EF and the ML. In the EF, there was a significant negative correlation between serum magnesium level and diastolic blood pressure (r= -0.374, p <0.05) and mean arterial pressure (r = -0.354, p < 0.05) but no significant correlation with systolic blood pressure. In the PO, there was no significant correlation between serum magnesium level and systemic arterial blood pressures. In the ML, there was significant negative correlation between serum magnesium level and systolic blood pressure (r = -0.651, p <0.001), diastolic blood pressure (r = -0.607, p <0.001), and mean arterial pressure (r = -0.661, p <0.001). Conclusion: The study concludes that serum magnesium level has a negative effect on blood pressure changes and the blood pressure-lowering effect of magnesium. These changes are related to the fluctuation of estrogen levels during the menstrual cycle.


Keywords


Serum magnesium, systemic arterial blood pressures, menstrual cycle reproductive system.

References