Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Study of Antifungal Activity of 2-methyl-3-(5'-aryl/Aryloxymethyl-1', 3', 4'-oxadiazol-2'-yl) Amino-1, 8-naphthyridines


Affiliations
1 Department of Chemistry,University College of Science, Mahatma Gandhi University, Nalgonda - 508544,, India
2 Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad - 501301, Telangana., India
     

   Subscribe/Renew Journal


We here in report promising fungicidal activity of a series of 1, 8-naphthyridine semicarbazides and amino-Oxadiazole derivatives. The biological activity of semicarbazides and amino-Oxadiazole derivatives were synthesized and screened for their antifungal activity against Alternariaalternata, Fusariumoxysporum and Curvularialunata fungal strains and have received significant attention due to their distinctive antifungal activity and found to be more potent.

Keywords

Antifungal activity, Alternariaalternata, Fusariumoxysporum, Curvularialunata.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Hide.G.A and Hirst.H.J Rep. RothanstedExpstn 1970; 1-40

  • Byrde RJ, Willetts HJ. The brown rot fungi of fruit: their biology and control. Elsevier. 2013; Oct 22.

  • Armarego WL, Batterham TJ. Proton magnetic resonance spectra of some Di-and Tri-azanaphthalenes and nitroisoquinolines. Journal of the Chemical Society B: Physical Organic.1966; 750-3.

  • Egawa H, Miyamoto T, Minamida A, Nishimura Y, Okada H, Uno H, Matsumoto J. Pyridonecarboxylic acids as antibacterial agents. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid and its analogs. Journal of medicinal chemistry. 1984; 27(12): 1543-8.

  • Suzuki N. Synthesis of antimicrobial agents. V. Synthesis and antimicrobial activities of some heterocyclic condensed 1, 8-naphthyridine derivatives. Chemical and Pharmaceutical Bulletin. 1980; 28(3): 761-8.

  • Lesher GY, Froctich EJ, GruettMD,Bailey JH and Brondage RP, J Med Chem. 1984; 5-1063.

  • Hirose T,NishimraY,OkadaH,Nakano J and Nakamura S, Japan Kokai (Tokyo), Jap Pat 01, 1990; 156-961

  • Gorecki DK, Hawes EM. 2, 3-Disubstituted 1, 8-naphthyridines as potential diuretic agents. Journal of Medicinal Chemistry. 1977; 20(1): 124-8.

  • Barlin G, Tan W. Potential antimalarials. I. 1, 8-naphthyridines. Australian journal of chemistry. 1984; 37(5): 1065-73.

  • PLFerrarini, C. Moric, G. Biogi, Livio, I. Tonelli; J. Het. Cycl., 1984; 24-417.

  • Mogilaiah K, Reddy KV, Sreenivasulu B. substituted 1, 8‐naphthyridines. part ii. Synthesis of 2‐styryl‐1, 3‐naphthyridines as antimicrobial agents. ChemischerInformationsdienst. 1983; 14-33.

  • Vijayender Reddy, K.Mogilaia, B.Sreenivasulu; J.Indian ChemSoc.1986; 63: 443-12

  • RamaRao G, Mogilaiah K, Rajender Reddy, and sreenivasulu B J Indian Chem Soc, 1987; 64-710

  • Laxminarayana E, Kumar MR, Ramesh D, Chary MT. A study on antimicrobial activity of 1, 8-naphthyridines containing triazinanones, oxadiazinanones, pyrazolyl and substituted pyrimidines.

  • Shailaja Rani H, Mogilaiah K, and sreenivasuluB,Indian J het cycl chem., 1995; 5, 45,

  • Seely H. Wand Van Demark P.J, Microbesin Action, W. H. Sanfrancisco, 1972; 163 17. Benda GT, Ricaud C. The use of heat treatment for sugarcane disease control. In Proceedings of the International Society of Sugarcane Technologists 1978; 16: 483-496.


Abstract Views: 136

PDF Views: 0




  • Study of Antifungal Activity of 2-methyl-3-(5'-aryl/Aryloxymethyl-1', 3', 4'-oxadiazol-2'-yl) Amino-1, 8-naphthyridines

Abstract Views: 136  |  PDF Views: 0

Authors

Ramesh Domala
Department of Chemistry,University College of Science, Mahatma Gandhi University, Nalgonda - 508544,, India
Annapoorna R. Sapuri Butti
Department of Chemistry,University College of Science, Mahatma Gandhi University, Nalgonda - 508544,, India
Laxminarayana Eppakayla
Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet, Ghatkesar, Hyderabad - 501301, Telangana., India

Abstract


We here in report promising fungicidal activity of a series of 1, 8-naphthyridine semicarbazides and amino-Oxadiazole derivatives. The biological activity of semicarbazides and amino-Oxadiazole derivatives were synthesized and screened for their antifungal activity against Alternariaalternata, Fusariumoxysporum and Curvularialunata fungal strains and have received significant attention due to their distinctive antifungal activity and found to be more potent.

Keywords


Antifungal activity, Alternariaalternata, Fusariumoxysporum, Curvularialunata.

References