Research Journal of Pharmacy and Technology

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Fluvoxamine Suppressed Oxidative Stress Associated with Tissue Erosion


Affiliations
1 Ninawa Health Directorate, Mosul,, Iraq
2 College of Medicine, University of Mosul,, Iraq
3 College of Veterinary Medicine University of Mosul,, Iraq
4 College of Pharmacy, University of Mosul, Mosul,, Iraq
     

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Centrally-acting drugs have been increasingly used for gastrointestinal diseases, such as opioids used for diarrhea and phenothiazine as antiemetic agents. Recent reports focused on the identification of the efficacy of these drugs in peptic ulcer protection; by tackling the oxidative stress associated with the inflammatory reaction of ulceration. The present study aimed to identify the differences between fluoxetine versus fluvoxamine in terms of antioxidant activity. To do so, an animal model of stress-induced ulcer was utilized by exposing rats to high doses of indomethacin and these rats were sub-classified into four groups (control, fluoxetine, fluvoxamine, and misoprostol) for comparison. Blood samples were collected from the studied groups and analyzed by measuring plasma levels of total antioxidant and malondialdehyde (MDA). The results confirmed that fluvoxamine possesses an antioxidant activity that is comparable to misoprostol and significantly higher than that of fluoxetine effects; the latter showed a non-significant effect in ordinary doses. In conclusion, these findings might provide a clue for future directions for the discovery of new antiulcer agents through structural modification of the newly introduced antidepressant agents in clinical use.

Keywords

Fluvoxamine, Fluoxetine, Indomethacin, Antioxidant, Malondialdehyde.
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  • Serretti A. Kato M. The Serotonin Transporter Gene and Effectiveness of SSRIs. Expert review of neurotherapeutics. 2008; 8(1):111-20.doi.org/10.1586/14737175.8.1.111

  • Geddes JR. Freemantle N. Mason J. Eccles M. Boynton J. Selective Serotonin Reuptake Inhibitors (SSRIs) Versus Other Antidepressants for Depression. Cochrane Database of Systematic Reviews. 1999; 1(4):111-20. doi.org/10.1002/14651858.CD001851

  • Locher C. Koechlin H. Zion SR. Werner C. Pine DS. Kirsch I et al. Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents: a Systematic Review and Meta-Analysis. JAMA psychiatry. 2017; 74(10):1011-20. doi:10.1001/jamapsychiatry.2017.2432.

  • Dursun H. Bilici M. Albayrak F. Ozturk C. Saglam MB. Alp HH et al. Antiulcer Activity of Fluvoxamine in Rats and Its Effect on Oxidant and Antioxidant Parameters in Stomach Tissue. BMC gastroenterology. 2009; 9(1):1-0. doi.org/10.1186/1471-230X-9- 36

  • Salem SS. Elsayed EM. Sabri AH. Serotonin and Histamine Mediate Gastroprotective Effect of Fluoxetine Against Experimentally-Induced Ulcers in Rats. Journal of immunotoxicology. 2016; 13(5):638-51. doi.org/10.3109/1547691X.2016.1145158

  • Sravanthi N. Alekhya K. Punitha S. Formulation and Process Scale up of Misoprostol Tablets. Research Journal of Pharmacy and Technology. 2011;4(11):1673-5.

  • Li YM. Lu GM. Zou XP. Li ZS. Peng GY. Fang DC. Dynamic Functional and Ultrastructural Changes of Gastric Parietal Cells Induced by Water Immersion-Restraint Stress in Rats. World Journal of Gastroenterology: WJG. 2006; 12(21):3368. doi.10.3748/wjg.v12.i21.3368

  • Ghosh R. Alajbegovic A. Gomes AV. NSAIDs and cardiovascular diseases: role of reactive oxygen species. Oxidative medicine and cellular longevity. 2015 Oct;2015.

  • Li H, Hortmann M, Daiber A. Oelze M. Ostad MA. Schwarz, P.M et al. Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases. Journal of Pharmacology and experimental therapeutics. 2008 Sep 1;326(3):745-53. doi.org/10.1124/jpet.108.139030

  • Vázquez-Meza H, de Piña MZ, Pardo JP. Riveros-Rosas H, Villalobos-Molina R, Piña E. Non-steroidal anti-inflammatory drugs activate NADPH oxidase in adipocytes and raise the H 2 O 2 pool to prevent cAMP-stimulated protein kinase a activation and inhibit lipolysis. BMC biochemistry. 2013 Dec;14(1):1-9. doi.org/10.1186/1471-2091-14-13

  • Ghosal N, Firdaus SB, Paul S. Naaz S, Chattopadhyay A, Shukla P et al. Amelioration of gastrotoxic effect of indomethacin by piperine in male Wistar rats: a novel therapeutic approach. Journal of Pharmacy Research. 2016 May;10(5):240-54.

  • Basivireddy J, Jacob M, Ramamoorthy P. Pulimood AB, Balasubramanian KA. Indomethacin-induced free radicalmediated changes in the intestinal brush border membranes. Biochemical pharmacology. 2003 Feb 15;65(4):683-95. doi.org/10.1016/S0006-2952(02)01616-7

  • Maziero Alves G, Aires R, de Souza Santos V. et al. Sildenafil attenuates nonsteroidal anti‐inflammatory‐induced gastric ulceration in mice via antioxidant and antigenotoxic mechanisms. Clinical and Experimental Pharmacology and Physiology. 2021 Mar;48(3):401-11.

  • Jacob M, Bjarnason I, Simpson RJ. Effects of indomethacin on energy metabolism in rat jejunal tissue in vivo. Clinical Science. 2002 May 1;102(5):541-6.

  • Karwani G, Singhvi I, Gupta S. Antisecretory and Antiulcer Activity of Cartaeva nurvala against Indomethacin plus Pyloric Ligation Induced Gastric Ulcers in Rats. Research J. Pharmacology and Pharmacodynamics. 2011 Oct 28;3(5):256-9.

  • Sandoval-Acuña C, Lopez-Alarcón C, Aliaga ME. Speisky H. Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action. Chemico-biological interactions. 2012 Jul 30;199(1):18-28. doi.org/10.1016/j.cbi.2012.05.006

  • Mazumder S, De R, Sarkar S. Siddiqui, A.A., Saha, S.J., Banerjee, C., et al. Selective scavenging of intra-mitochondrial superoxide corrects diclofenac-induced mitochondrial dysfunction and gastric injury: a novel gastroprotective mechanism independent of gastric acid suppression. Biochemical pharmacology. 2016 Dec 1;121:33- 51. doi.org/10.1016/j.bcp.2016.09.027

  • Fathi ZH, Mohammad JA, Mohammed MH. Levels of Myeloperoxidase, Malondialdehyde and Lipid Profile in Type 2 Diabetic Patients on Metformin Versus Glibenclamide Therapy. Age (years). 2020;43:6-14.

  • Aliahmat NS, Noor MR, Yusof WJ. Makpol S, Ngah WZ, Yusof YA. Antioxidant enzyme activity and malondialdehyde levels can be modulated by Piper betle, tocotrienol rich fraction and Chlorella vulgaris in aging C57BL/6 mice. Clinics. 2012 Dec;67(12):1447-54. doi.org/10.6061/clinics/2012(12)16

  • Sabiu S, Garuba T, Sunmonu TO. Ismail NO. Indomethacininduced gastric ulceration in rats: ameliorative roles of Spondias mombin and Ficus exasperata. Pharmaceutical biology. 2016 Jan 2;54(1):180-6. doi.org/10.3109/13880209.2015.1029050

  • Morales M, Munné-Bosch S. Malondialdehyde: Facts and artifacts. Plant physiology. 2019 Jul 1;180(3):1246-50. doi.org/10.1104/pp.19.00405

  • Devadasu CH, Harika S, Mallikarjuna T. Adilakshmi G, Sreenath A, Ratna GS et al. A Spectrophotometric Assay for the Simultaneous Analysis of Mifepristone and Misoprostol in Tablets Using Vierodt's and Absorbance Ratio Methods. Research Journal of Pharmacy and Technology. 2012;5(1):46-9.

  • Das R, Agrawal YK. Simultaneous monitoring of selective serotonin reuptake inhibitors in human urine, plasma and oral fluid by reverse-phase high performance liquid chromatography. Journal of chromatographic science. 2013 Feb 1;51(2):146-54. doi.org/10.1093/chromsci/bms119

  • Sørensen L, Andersen J, Thomsen M. Hansen SM, Zhao X, Sandelin A, et al. Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. Journal of Biological Chemistry. 2012 Dec 21;287(52):43694-707. doi.org/10.1074/jbc.M112.342212

  • Nguyen CM. Tartar DM. Bagood MD. So M. Nguyen AV. Gallegos A. et al. Topical Fluoxetine as a novel therapeutic that improves wound healing in diabetic mice. Diabetes. 2019 Jul 1;68(7):1499-507. doi.org/10.2337/db18-1146


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  • Fluvoxamine Suppressed Oxidative Stress Associated with Tissue Erosion

Abstract Views: 129  |  PDF Views: 0

Authors

Sada W. Abdulqader
Ninawa Health Directorate, Mosul,, Iraq
Ibrahim M. Faisal
College of Medicine, University of Mosul,, Iraq
M. G. Saeed
College of Veterinary Medicine University of Mosul,, Iraq
Marwan M. Merkhan
College of Pharmacy, University of Mosul, Mosul,, Iraq

Abstract


Centrally-acting drugs have been increasingly used for gastrointestinal diseases, such as opioids used for diarrhea and phenothiazine as antiemetic agents. Recent reports focused on the identification of the efficacy of these drugs in peptic ulcer protection; by tackling the oxidative stress associated with the inflammatory reaction of ulceration. The present study aimed to identify the differences between fluoxetine versus fluvoxamine in terms of antioxidant activity. To do so, an animal model of stress-induced ulcer was utilized by exposing rats to high doses of indomethacin and these rats were sub-classified into four groups (control, fluoxetine, fluvoxamine, and misoprostol) for comparison. Blood samples were collected from the studied groups and analyzed by measuring plasma levels of total antioxidant and malondialdehyde (MDA). The results confirmed that fluvoxamine possesses an antioxidant activity that is comparable to misoprostol and significantly higher than that of fluoxetine effects; the latter showed a non-significant effect in ordinary doses. In conclusion, these findings might provide a clue for future directions for the discovery of new antiulcer agents through structural modification of the newly introduced antidepressant agents in clinical use.

Keywords


Fluvoxamine, Fluoxetine, Indomethacin, Antioxidant, Malondialdehyde.

References