Research Journal of Pharmacy and Technology

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Transferosomes as an Efficient Carrier System for Better Therapeutic Response of Targeted Drug Delivery System


Affiliations
1 Amity Institute of Pharmacy, Lucknow, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India
2 Faculty of Pharmacy, DIT University, Dehradun,, India
     

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BACKGROUND: Targeted drug delivery systems (TDDS) mainly focuses to aim the medication to a specific organ site and hence reducing the amount of drug in remaining tissues therefore, improving its bioavailability and therapeutic index at the targeted site. This helps in minimizing the adverse effects and improves its efficacy. OBJECTIVE: Presently there are different carrier systems like liposomes, transferosomes, pharmacosomes, phytosomes, aquasomes, niosomes, solid lipid nanoparticles, microparticles, nanoparticles, etc. are being used for the purpose of site specific drug delivery and also to prevent drug candidate from metabolic degradation process. The major focus of this review work is on Transferosomes proves as an efficient carrier for target delivery of drugs. The drugs molecules get decomposed due to different metabolic processess and other physiological conditions of the body; this emerges the need for site specific systems for drug delivery to prevent the drug molecules. This site specific process is also known as smart drug delivery because these nanocarrier systems significantly changes their physiochemical properties in response to internal environment of the body and release the drug at its targeted site at a specific rate according to severity of the disease. CONCLUSION: The applications of these nano systems like fabrication, encapsulation, response to various stimuli are vital for site specific delivery of drugs. Nanotechnological application in drug delivery enhances the process of drug delivery. There are various kinds of nano-size particulate systems that are already approved for their clinical use although these are now in their development stages. This will be a major focus for future drug targeting with various newer molecules.

Keywords

Targeted drug delivery system, Transferosomes, Nanotechnology, Cancer, Carrier.
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  • A.M. Hillery and A.H. Lloyd, Drug delivery and targeting, London, Taylor and Francis e-Library, 2005.

  • Gupta M, Sharma V; Targeted drug delivery system: A Review. Research Journal of Chemical Sciences, 2011; 1:134-138.

  • M. Gupta and V. Sharma, Research Journal of Chemical Sciences., 2011; 1(2): 136-137.

  • Martinho N, Damgé C, Reis CP. Recent advances in drug delivery systems. Journal of Biomaterials and Nanobiotechnology. 2011 Dec 9;2(05):510.

  • https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.mdpi.com%2F20794991%2F5%2F4%2F1690%2Fhtm&psig=AOvVaw1i0_Gu_By3woqEerKk62Ie&ust=1598171384857000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCLCo3PCyrusCFQAAAAAdAAAAABAY

  • Rani K, Paliwal S. A review on targeted drug delivery: Its entire focus on advanced therapeutics and diagnostics. Sch. J. App. Med. Sci. 2014;2(1C):328-1.

  • Bae YH, Park K. Targeted drug delivery to tumors: myths, reality and possibility. Journal of Controlled Release. 2011 Aug 10;153(3):198.

  • Agnihotri J, Saraf S, Khale A. Targeting: new potential carriers for targeted drug delivery system. International Journal of Pharmaceutical Sciences Review and Research. 2011;8(2):117-23.

  • Nimisha Srivastava, Zeeshan Fatima, Chanchal Deep Kaur and Dilshad Ali Rizvi, “Berberine Chloride Dihydrate Enthused Nanovesicles for the Management of Dermatitis Nanovesicles for Dermatitis”, Nanoscience and Nanotechnology-Asia (2020) 10: 1.

  • Fatima Z. Formulation and Performance evaluation of Berberis aristata extract loaded ethosomal gel. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm. 2017 Sep 9;11(03).

  • Nimisha DA, Fatima Z, Neema CD. Antipsoriatic and anti-inflammatory studies of Berberis aristata extract loaded nanovesicular gels. Pharmacognosy Magazine. 2017 Oct;13(Suppl 3): S587.

  • Srivastava K., Nimisha, Singh AK, Formulation and evaluation of seabuckthorn leaf extract loaded ethosomal gel, Asian journal of Pharmaceutical and Clinical Research, Vol 8, Issue 5, 2015; 309-312.

  • Pandey K. An Overview on Promising Nanotechnological Approaches for the Treatment of Psoriasis. Recent Patents on Nanotechnology. 2020 Jun 1;14(2):102-18.

  • Singh A, Srivastava N. Novel Nanolipoidal Systems for the Management of Skin Cancer. Recent Patents on Drug Delivery and Formulation. 2020 Aug 17.

  • Singh N, Singh A, Pandey K. Current Insights for the Management of Acne in the Modern era. Recent Patents on Anti-infective Drug Discovery. 2020 Jul 29.

  • Fatima Z, Kaur CD. A review on potential of novel vesicular carriers for carrying herbal drugs in the treatment of dermatological disorders. Journal of Atoms and Molecules. 2016 May 1;6(3):987.

  • Sezer AD, editor. Recent advances in novel drug carrier systems. BoD–Books on Demand; 2012 Oct 31.

  • Deepak HB, Prince SE. A Systematic Review on the Role of PD-1 and its Ligands in Autoimmunity. Research Journal of Pharmacy and Technology. 2017;10(8):2771-6.

  • Vijayalakshmi A, Srinivas P, Vinodh MN, Gaffur A, Singh UK. Antimicrobial activity of Antipsoriatic Plant Givotia rottleriformis Griff. Ex Wight. Research Journal of Pharmacy and Technology. 2016;9(8):1109-14.

  • Kavitha S. Pharmacognostical Evaluation and Standardisation of Ayurvedic Formulation Patoladi Kwatha Churna for Psoriasis. Research Journal of Pharmacy and Technology. 2020;13(3):1171-4.

  • Kalimuthu S, Yadav AV. Nanobased Drug Delivery System: A Review. Research Journal of Pharmacy and Technology. 2009;2(1):21-7.

  • Patidar V, Sharma D, Maliwal D, Chatap V. Penetration Enhancement Techniques for Transdermal Drug Delivery System. Research Journal of Pharmacy and Technology. 2009;2(1):28-33.

  • Srisuk P, Thongnopnua P, Raktanonchai U, Kanokpanont S. Physico-chemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment. International Journal of Pharmaceutics. 2012 May 10;427(2):426-34.

  • Nasr M, Mansour S, Mortada ND, Elshamy AA. Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. Journal of Microencapsulation. 2008 Oct 1;25(7):499-512.

  • Srisuk P, Thongnopnua P, Raktanonchai U, Kanokpanont S. Physico-chemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment. International Journal of Pharmaceutics. 2012 May 10;427(2):426-34.

  • Nasr M, Mansour S, Mortada ND, El Shamy AA. Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation. Aaps Pharmscitech. 2008 Mar 1;9(1):154-62.

  • Patel PA, Chaulang GM, Akolkotkar A, Mutha SS, Hardikar SR, Bhosale AV. Self-emulsifying drug delivery system: A review. Research Journal of Pharmacy and Technology. 2008;1(4):313-23.

  • Mayavanshi AV, Gajjar SS. Floating drug delivery systems to increase gastric retention of drugs: A Review. Research Journal of Pharmacy and Technology. 2008;1(4):345-8.

  • Chien YW. Novel drug delivery systems. New York: Marcel Decker Inc; 1982; 149-215.

  • Cevc G, Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2001 Oct 1;1514(2):191-205.

  • Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochimica et Biophysica Acta-Biomembranes. 1992 Feb 17;1104(1):226-32.

  • Elsayed MM, Abdallah OY, Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: reviewing three decades of research. International Journal of Pharmaceutics. 2007 Mar 6;332(1-2):1-6.

  • Gupta M, Agrawal U, Vyas SP. Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opinion on Drug Delivery. 2012 Jul 1;9(7):783-804.

  • Cevc G, Schätzlein A, Blume G. Transdermal drug carriers: basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides. Journal of Controlled Release. 1995 Sep 1;36(1-2):3-16.

  • El Zaafarany GM, Awad GA, Holayel SM, Mortada ND. Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. International Journal of Pharmaceutics. 2010 Sep 15;397(1-2):164-72.

  • Chuanping N, Hongzhao C, Weiying G. Preparation and Study on Properties of Ibuprofen Transfersomes. Journal of Mathematical Medicine. 2010;2.

  • Shen Y, Zhang Y. Liao Ming. Preparation and quality evaluation of drug loading transferosomes. Med J Chin People's Liberation Army. 2007;10.

  • Malakar J, Sen SO, Nayak AK, Sen KK. Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery. Saudi Pharmaceutical journal. 2012 Oct 1;20(4):355-63.

  • Trotta M, Peira E, Carlotti ME, Gallarate M. Deformable liposomes for dermal administration of methotrexate. International Journal of Pharmaceutics. 2004 Feb 11;270(1-2):119-25.

  • Bhatia A, Singh B, Wadhwa S, Raza K, Katare OP. Novel phospholipid-based topical formulations of tamoxifen: evaluation for antipsoriatic activity using mouse-tail model. Pharmaceutical Development and Technology. 2014 Mar 1;19(2):160-3.

  • Bseiso EA, Nasr M, Sammour O, Abd El Gawad NA. Recent advances in topical formulation carriers of antifungal agents. Indian Journal of Dermatology, Venereology, and Leprology. 2015 Sep 1;81(5):457.

  • Duangjit S, Opanasopit P, Rojanarata T, Ngawhirunpat T. Characterization and in vitro skin permeation of meloxicam-loaded liposomes versus transfersomes. Journal of Drug Delivery. 2011;2011.

  • Jain S, Jain P, Umamaheshwari RB, Jain NK. Transfersomes—a novel vesicular carrier for enhanced transdermal delivery: development, characterization, and performance evaluation. Drug Development and Industrial Pharmacy. 2003 Jan 1;29(9):1013-26.

  • Patel R, Singh SK, Singh S, Sheth NR, Gendle R. Development and characterization of curcumin loaded transfersome for transdermal delivery. Journal of Pharmaceutical Sciences and Research. 2009 Dec 1;1(4):71.

  • Pandey S, Goyani M, Devmurari V, Fakir J. Transferosomes: a novel approach for transdermal drug delivery. Der Pharmacia Lettre. 2009;1(2):143-50.

  • Boinpally RR, Zhou SL, Poondru S, Devraj G, Jasti BR. Lecithin vesicles for topical delivery of diclofenac. European journal of Pharmaceutics and Biopharmaceutics. 2003 Nov 1;56(3):389-92.

  • Cevc G. Material transport across permeability barriers by means of lipid vesicles. In Handbook of Biological Physics 1995 Jan 1 (Vol. 1, pp. 465-490). North-Holland.

  • Chaubey R, Srivastava N, Singh A. Enhancement of Dissolution Rate of Quercetin Using Solid Dispersion Approach: In Vitro and In Vivo Evaluation. Nanoscience and Nanotechnology-Asia. 2020 Jun 1;10(3):330-49.

  • Jain S, Umamaheswari RB, Bhadra D, Tripathi P, Jain P, Jain NK. Ultradeformable liposomes: A recent tool for effective transdermal drug delivery. Indian Journal of Pharmaceutical Sciences. 2003;65(3):223.

  • Barry B. Transdermal drug delivery. In: Aulton EM. (editor). Pharmaceutics, The science of dosage forms design, 2nd ed., Churchill Livingstone, Newyork: Harcourt Publishers; 2002; 499-33.

  • Singodia D, Gupta GK, Verma A, Singh V, Shukla P, Misra P, Sundar S, Dube A, Mishra PR. Development and performance evaluation of amphotericin B transfersomes against resistant and sensitive clinical isolates of visceral leishmaniasis. Journal of Biomedical Nanotechnology. 2010 Jun 1;6(3):293-302.

  • https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.semanticscholar.org%2Fpaper%2FHERBAL-NOVEL-DRUG-DELIVERY-SYSTEMS-AND-Chauhan Tyagi%2Fa64a84efb14966cdd98ce2a96cca130157fbeae7&psig=AOvVaw3cxzjWe9v9OHEOYC6IKu6k&ust=1598185308560000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCKj2ysrmrusCFQAAAAAdAAAAABAK

  • https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.slideshare.net%2Fsagarsavale1%2Ftransfersome&psig=AOvVaw3J3PtnkGjeE0L3hzS7IThI&ust=1598186135843000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCPjBscDqrusCFQAAAAAdAAAAABAD

  • Azimi M, Khodabandeh M, Deezagi A, Rahimi F. Impact of the Transfersome Delivered Human Growth Hormone on the Dermal Fibroblast Cells. Current Pharmaceutical Biotechnology. 2019 Nov 1;20(14):1194-202.

  • Jiang T, Wang T, Li T, Ma Y, Shen S, He B, Mo R. Enhanced transdermal drug delivery by transfersome-embedded oligopeptide hydrogel for topical chemotherapy of melanoma. ACS Nano. 2018 Sep 5;12(10):9693-701.

  • Wu X, Li Y, Chen X, Zhou Z, Pang J, Luo X, Kong M. A surface charge dependent enhanced Th1 antigen-specific immune response in lymph nodes by transfersome-based nanovaccine-loaded dissolving microneedle-assisted transdermal immunization. Journal of Materials Chemistry B. 2019;7(31):4854-66.

  • Yang J, Liu X, Fu Y, Song Y. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharmaceutica Sinica B. 2019 May 1;9(3):469-83.

  • Salem HF, Kharshoum RM, Abou-Taleb HA, Naguib DM. Nanosized transferosome-based intranasal in situ gel for brain targeting of resveratrol: formulation, optimization, in vitro evaluation, and in vivo pharmacokinetic study. AAPS PharmSciTech. 2019 Jul 1;20(5):181.

  • Omar MM, Hasan OA, El Sisi AM. Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation. International Journal of Nanomedicine. 2019; 14:1551.

  • Van Zyl L, Viljoen JM, Haynes RK, Aucamp M, Ngwane AH, du Plessis J. Topical delivery of artemisone, clofazimine and decoquinate encapsulated in vesicles and there in vitro efficacy against Mycobacterium tuberculosis. AAPS PharmSciTech. 2019 Jan 1;20(1):33.

  • Hadidi N, Saffari M, Faizi M. Optimized Transferosomal Bovine Lactoferrin (BLF) as a Promising Novel Non-Invasive Topical Treatment for Genital Warts Caused by Human Papiluma Virus (HPV). Iranian Journal of Pharmaceutical Research: IJPR. 2018;17(Suppl2):12.


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  • Transferosomes as an Efficient Carrier System for Better Therapeutic Response of Targeted Drug Delivery System

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Authors

Rishabh Gupta
Amity Institute of Pharmacy, Lucknow, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India
Manmohan Singhal
Faculty of Pharmacy, DIT University, Dehradun,, India
Nimisha
Amity Institute of Pharmacy, Lucknow, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India

Abstract


BACKGROUND: Targeted drug delivery systems (TDDS) mainly focuses to aim the medication to a specific organ site and hence reducing the amount of drug in remaining tissues therefore, improving its bioavailability and therapeutic index at the targeted site. This helps in minimizing the adverse effects and improves its efficacy. OBJECTIVE: Presently there are different carrier systems like liposomes, transferosomes, pharmacosomes, phytosomes, aquasomes, niosomes, solid lipid nanoparticles, microparticles, nanoparticles, etc. are being used for the purpose of site specific drug delivery and also to prevent drug candidate from metabolic degradation process. The major focus of this review work is on Transferosomes proves as an efficient carrier for target delivery of drugs. The drugs molecules get decomposed due to different metabolic processess and other physiological conditions of the body; this emerges the need for site specific systems for drug delivery to prevent the drug molecules. This site specific process is also known as smart drug delivery because these nanocarrier systems significantly changes their physiochemical properties in response to internal environment of the body and release the drug at its targeted site at a specific rate according to severity of the disease. CONCLUSION: The applications of these nano systems like fabrication, encapsulation, response to various stimuli are vital for site specific delivery of drugs. Nanotechnological application in drug delivery enhances the process of drug delivery. There are various kinds of nano-size particulate systems that are already approved for their clinical use although these are now in their development stages. This will be a major focus for future drug targeting with various newer molecules.

Keywords


Targeted drug delivery system, Transferosomes, Nanotechnology, Cancer, Carrier.

References