Research Journal of Pharmacy and Technology

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Glycerosomes: A Novel Vesicular Drug Delivery System


Affiliations
1 Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur (U.P.), India
     

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Glycerosomes are novel vesicular drug delivery systems used both for topical as well as systemic drug delivery. These noninvasive carriers can penetrate into the deeper layer of skin to such extent a free drug would not penetrate. Glycerosomes are composed of phospholipids, water and high concentration of glycerol (from 20 to 40%), which are harmless and fully acceptable ingredients for topical preparations. High concentration of glycerol gives positive contributes to the penetration of drug by increasing flexibility of vesicles; italso enhances the stability of vesicles.They have capability to encapsulate both lipophilic and hydrophilicdrugs and protect them from degradation. Now a days glycerosomal carrier are the most interesting area of work for researchers. This review article summarizes the structure, advantages, composition, methods of preparations, characterization and applications of glycerosomes.

Keywords

Glycerosomes, Novel formulaion, Glycerol, Penetration.
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  • Glycerosomes: A Novel Vesicular Drug Delivery System

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Authors

Deepika Rani
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur (U.P.), India
Vaishali Sharma
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur (U.P.), India
Pinki Singh
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur (U.P.), India
Ranjit Singh
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur (U.P.), India

Abstract


Glycerosomes are novel vesicular drug delivery systems used both for topical as well as systemic drug delivery. These noninvasive carriers can penetrate into the deeper layer of skin to such extent a free drug would not penetrate. Glycerosomes are composed of phospholipids, water and high concentration of glycerol (from 20 to 40%), which are harmless and fully acceptable ingredients for topical preparations. High concentration of glycerol gives positive contributes to the penetration of drug by increasing flexibility of vesicles; italso enhances the stability of vesicles.They have capability to encapsulate both lipophilic and hydrophilicdrugs and protect them from degradation. Now a days glycerosomal carrier are the most interesting area of work for researchers. This review article summarizes the structure, advantages, composition, methods of preparations, characterization and applications of glycerosomes.

Keywords


Glycerosomes, Novel formulaion, Glycerol, Penetration.

References