Research Journal of Pharmacy and Technology

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Clinical Evaluation of Efficacy of Rasarakta Pachak Ghanavati in Hyperlipidaemia (Rasagat Sneha Vriddhi)


Affiliations
1 Assistant Professor, Department of Kayachikitsa, Global Institute of Ayurveda and Hospital, Rajkot, Gujrat 360020 and Former P.G. Scholar, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
2 Principal, Professor and HOD, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
3 Assistant Professor, Department of Kayachikitsa, Prabuddh Ayurvedic Medical College Hospital and Research Centre, Lucknow, Uttar Pradesh and Former P.G. Scholar, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
4 Associate Professor, Department of RS and BK, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
5 Professor, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
     

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Hyperlipidaemia is one such lifestyle disorder which is identified as an impending risk factor for many diseases like hypertension, metabolic syndrome, coronary artery disease (CAD) and cerebrovascular diseases (CVD). In Hyperlipidaemia levels of lipoproteins i.e. (cholesterol, triglycerides, or both) are raised in the plasma, which can be co-related to elevated Sneha or Meda Dhatu in the body. As drugs used in modern medicine viz. statins, fibrates etc. to treat hyperlipidaemia has several adverse effects such as myopathy, potential elevation in serum transaminase levels leading to hepatic damage, nausea or vomiting, bowel upset, multiple joint pain etc. Hence, it is very much necessary to have definite and harmless solution to this problem. Apatarpan is the treatment advocated in ayurved for Santarpanjanya Vyadhis and Hyperlipidaemia is one among this group of disease. Taking into consideration all the treatment modalities in Ayurveda, Rasarakta Pachak Ghanavati was given as a line of treatment in Hyperlipidaemia. Methods - 60 patients of Hyperlipidaemia as per the objective criteria of range for lipid profile mentioned in American Journal of Lifestyle Medicine were randomly selected from OPD and IPD of Dr. D. Y. Patil College of Ayurved and Research centre, Pimpri, Pune. Group A (n=30) patients were treated with Rasarakta Pachak Ghanavati (500mg) 2 tabs twice in a day after food for 30 days and Group B (n=30) patients were treated with Tab Atorvastatin (10mg) 1 tab once in a day after food for 30 days. Result- Rasarakta Pachak Ghanavati group showed marked improvement on Serum Total Cholesterol and Serum LDL – Cholesterol and moderate improvement on Serum Triglycerides and Serum HDL – Cholesterol parameters of lipid profile. While Tab Atorvastatin group showed marked improvement on almost all the parameters of lipid profile

Keywords

Hyperlipidaemia, Rasarakta pachak ghanavati, Apatarpan chikitsa, Lipid profile, Cholesterol.
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  • Clinical Evaluation of Efficacy of Rasarakta Pachak Ghanavati in Hyperlipidaemia (Rasagat Sneha Vriddhi)

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Authors

Khyati B. Rohit
Assistant Professor, Department of Kayachikitsa, Global Institute of Ayurveda and Hospital, Rajkot, Gujrat 360020 and Former P.G. Scholar, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
Gunvant H. Yeola
Principal, Professor and HOD, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
Kalyani P. Nishane
Assistant Professor, Department of Kayachikitsa, Prabuddh Ayurvedic Medical College Hospital and Research Centre, Lucknow, Uttar Pradesh and Former P.G. Scholar, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
Amol H. Waghmare
Associate Professor, Department of RS and BK, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India
D. G. Dipankar
Professor, Department of Kayachikitsa, Dr. D. Y. Patil College of Ayurved and Research Centre, Pimpri, Pune of Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University)., India

Abstract


Hyperlipidaemia is one such lifestyle disorder which is identified as an impending risk factor for many diseases like hypertension, metabolic syndrome, coronary artery disease (CAD) and cerebrovascular diseases (CVD). In Hyperlipidaemia levels of lipoproteins i.e. (cholesterol, triglycerides, or both) are raised in the plasma, which can be co-related to elevated Sneha or Meda Dhatu in the body. As drugs used in modern medicine viz. statins, fibrates etc. to treat hyperlipidaemia has several adverse effects such as myopathy, potential elevation in serum transaminase levels leading to hepatic damage, nausea or vomiting, bowel upset, multiple joint pain etc. Hence, it is very much necessary to have definite and harmless solution to this problem. Apatarpan is the treatment advocated in ayurved for Santarpanjanya Vyadhis and Hyperlipidaemia is one among this group of disease. Taking into consideration all the treatment modalities in Ayurveda, Rasarakta Pachak Ghanavati was given as a line of treatment in Hyperlipidaemia. Methods - 60 patients of Hyperlipidaemia as per the objective criteria of range for lipid profile mentioned in American Journal of Lifestyle Medicine were randomly selected from OPD and IPD of Dr. D. Y. Patil College of Ayurved and Research centre, Pimpri, Pune. Group A (n=30) patients were treated with Rasarakta Pachak Ghanavati (500mg) 2 tabs twice in a day after food for 30 days and Group B (n=30) patients were treated with Tab Atorvastatin (10mg) 1 tab once in a day after food for 30 days. Result- Rasarakta Pachak Ghanavati group showed marked improvement on Serum Total Cholesterol and Serum LDL – Cholesterol and moderate improvement on Serum Triglycerides and Serum HDL – Cholesterol parameters of lipid profile. While Tab Atorvastatin group showed marked improvement on almost all the parameters of lipid profile

Keywords


Hyperlipidaemia, Rasarakta pachak ghanavati, Apatarpan chikitsa, Lipid profile, Cholesterol.

References