Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Investigating the Use of Liquisolid Compact Technique for Pioglitazone Hcl


Affiliations
1 Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore - 641004, Tamilnadu,, India
     

   Subscribe/Renew Journal


The aim of present study is to enhance the dissolution of poorly water soluble drug of Pioglitazone HCl by liquisolid compact technique. Liquisolid compact were prepared using propylene glycol as non-volatile solvent, Avicel PH102 as carrier and Aerosil 200 as coating material, sodium starch glycolate as superdisintegrant.The compatibility of excipients and drug was confirmed by FT-IR studies. The dissolution studies for prepared liquisolid tablet were distinctly higher as compared to directly compressed tablets which show significance increased in wetting properties and surface area of drug available for dissolution. The optimized PIO-7 liquisolid formulation shows acceptable flow properties, faster disintegration time and superior dissolution profile. The optimized formulation of liquisolid pioglitazone tablet shows higher drug release when compared to marketed formulation. The mechanism of drug release studied for best formulations where fitted in accordance with higuchi model and korsemeyer peppas model it is evident that a linear relationship was obtained showing that is an apparent first order process.

Keywords

Liquisolid Compacts, Pioglitazone HCl, Dissolution, release kinetics, superdisintegrant.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Lipinski CA, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Delivery Rev.1997; 23(1-3):3–26.

  • Amidon GL, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res.1999; 12(3):413–420.

  • Wong SM, et al. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing micro particles. Int J pharma.2006; 317(1):61-68.

  • Prajapat D, et al. Liquisolid: A promising technique to improve dissolution efficiency and bioavailability of poorly water soluble nimodipine. Journal of Drug Delivery Science and Technology. 2019; 53(101135):1-9

  • Asija Rajesh, et al. The Liquisolid technique for enhancement of drug dissolution. Research J Pharm and Tech.2012; 5(10):1270-1274.

  • Spireas S, et al. Powered Solution Technology: Principles and Mechanism. Pharm Res.1992; 9(10):1351

  • Spireas S, Bolton SM. Liquisolid systems and methods of preparing same. US5968550, 1999.

  • Spireas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolid compacts. Int J Pharm.1998; 166(2):177–188.

  • Bhosale, et al. Development of Pioglitazone hydrochloride lipospheres by melt dispersion technique: Optimization and evaluation. Journal of Applied Pharmaceutical Science. 2016; 6(01): 107-117

  • Sugita M, et al.Effect of excipients on the particle size of precipitated Pioglitazone in gastrointestinal tract: Impact on Bioequivalence. AAPS.2014; 16(5):1119-1127.

  • El-Hammadi M, Awad N. Investigating the use of liquisolid compacts technique to minimize the influence of pH variations on loratadine release. AAPS Pharm Sci Tech. 2012; 13(1):53-58.

  • Ashok A Hajare, et al. Enhancement of dissolution rate and formulation development of efavirenz capsule employing solid dispersion.Research J Pharm and Tech. 2013; 6(1):112-117.

  • Suryawanshi, et al. Formulation and Evaluation of Ramipril liquisolid Compact using novel carrier. IJPSR.2019; 10(2):917-925.

  • Anusuya Patil, et al. Enhancement of nateglinide solubility and dissolution rate. Research J Pharm and Tech. 2011; 4(7):1159-1164. 15. Spireas S, Bolton. U.S.Patent.2000; 6(096):337.

  • Jadhav Ambadas, et al. Liquisolid technique a novel approach to enhance solubility and dissolution rate: A review. Research J Pharm and Tech. 2013; 6(8):819-824.

  • Nawal A, Rajab. Preparation and in vitro evaluation of lacidipine oral liquid solid tablet as an approach of solubility and dissolution rate enhancement. International J App Pharm.2018; 10(1):145-153.

  • Swamivelmanickam M, et al. Preparation and evaluation of mouth dissolving tablets of loratidine by direct compression method. Research J Pharm and Tech. 2020; 13(6):2629-2633.

  • Javadzadeh Y, et al. Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices. Int J Pharm. 2008; 362(1-2):102–108.

  • Naik E, et al.Liquisolid technique using tween 80 and sodium starch glycol ate to enhance the solubility and dissolution rate of an antihypertensive drug. Latin American Journal of Pharmacy. 2019; 37(4): 717-726.

  • Hentzschel CM, et al. Enhancement of griseofulvin release from liquisolid compacts. Eur. J. Pharm. Biopharm. 2012;80(1):130–135.

  • Nawaz Mahammed, et al. Formulation and evaluation of Clopidrogel Bisulphate tablets by Liquisolid Compact technique. Research J Pharm and Tech. 2020; 13(5):2427-2434.

  • Mohan Dhere, et al. Formulation and evaluation of liquisolid Compact on NSAID Naproxen. Research J Pharm and Tech.2014; 7(3):284-289.

  • Umesh D Shivhare, et al. Effect of non volatile solvent on Dissolution Profile of carvedilol Liquisolid Compact. Research J Pharm and Tech. 2011; 4(4):537-544.

  • Anand Patel, et al. Development and evaluation of sustain release Pioglitazone microsphere. Research J Pharm and Tech.2018; 11(12): 5348-5354.

  • Suvakanta Dash, et al. Kinetic modeling on drug release from controlled drug delivery systems. Acta Poloniae Pharmaceutics. 2010; 67(3): 217- 223.

  • Gouda, et al. Application of mathematical models in drug release kinetics of carbidopa and levodopa ER tablets. Develop Drugs. 2017; 6(2):1- 8.

  • Mohamed Rizwan I, et al. Mathematical modeling of dissolution kinetics in dosage forms. Research J Pharm and Tech. 2020; 13(3): 1339-1345.


Abstract Views: 173

PDF Views: 0




  • Investigating the Use of Liquisolid Compact Technique for Pioglitazone Hcl

Abstract Views: 173  |  PDF Views: 0

Authors

S. Subramanian
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore - 641004, Tamilnadu,, India
V. Monisha
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore - 641004, Tamilnadu,, India

Abstract


The aim of present study is to enhance the dissolution of poorly water soluble drug of Pioglitazone HCl by liquisolid compact technique. Liquisolid compact were prepared using propylene glycol as non-volatile solvent, Avicel PH102 as carrier and Aerosil 200 as coating material, sodium starch glycolate as superdisintegrant.The compatibility of excipients and drug was confirmed by FT-IR studies. The dissolution studies for prepared liquisolid tablet were distinctly higher as compared to directly compressed tablets which show significance increased in wetting properties and surface area of drug available for dissolution. The optimized PIO-7 liquisolid formulation shows acceptable flow properties, faster disintegration time and superior dissolution profile. The optimized formulation of liquisolid pioglitazone tablet shows higher drug release when compared to marketed formulation. The mechanism of drug release studied for best formulations where fitted in accordance with higuchi model and korsemeyer peppas model it is evident that a linear relationship was obtained showing that is an apparent first order process.

Keywords


Liquisolid Compacts, Pioglitazone HCl, Dissolution, release kinetics, superdisintegrant.

References