Research Journal of Pharmacy and Technology

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Formulation and Evaluation of Ethosomal Gel and Non-ethosomal Gel of S.Grandiflora Leaves


Affiliations
1 1Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab-151401., India
2 Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra,411038., India
3 Department of Pharmaceutical Sciences, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune - 411019, MH, India
     

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The numbers of products based on new drug delivery systems have considerably increased in the past few years, and this growth is projected to carry on in the future. These bio-pharmaceuticals present challenges to drug delivery system because of their different nature and difficulty in delivery through conventional routes. Therefore, further research will focus on the delivery of these complex molecules through different routes, including nasal, pulmonary, vaginal, rectal, etc. The intend of the study was to formulate and evaluate ethosomes of Sesbania grandiflora leaves which may transport the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. Trans-dermal drug delivery is a technique which can be exploited to overcome the variables, which could affect the oral absorption of drugs such as pH, food intake and gastrointestinal motility. As compared to liposome or hydro-alcoholic solution ethosomal systems were much more capable at delivering a fluorescent probe to the skin in terms of quantity and depth. The formulations were prepared with ethanol, lecithin, propylene glycol, and glycerol and were evaluated. The lecithin (phospholipids) used as a vesicles forming component, polyglycol and ethanol used as a skin penetration enhancer. The drug released of formulated ethosomal gel was 4-5 times improved as compared to non ethosomal gel which directly achieves unparalleled flexibility in formulation. Ethosomal gel successfully addresses the issues relating to the drug delivery of poorly water-soluble drugs, peptides, potent drugs and the release of multi-drugs.

Keywords

Sesbania grandiflora, Ethosomes, Bioavailability, Transdermal, Ethosomal-gel, Nano-carrier, novel drug delivery, Diffusion.
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  • Formulation and Evaluation of Ethosomal Gel and Non-ethosomal Gel of S.Grandiflora Leaves

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Authors

Rohan Rajkumar Patekar
1Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab-151401., India
Heena Bholaram Choudhary
Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra,411038., India
Sachin Devidas Rede
Department of Pharmaceutical Sciences, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune - 411019, MH, India

Abstract


The numbers of products based on new drug delivery systems have considerably increased in the past few years, and this growth is projected to carry on in the future. These bio-pharmaceuticals present challenges to drug delivery system because of their different nature and difficulty in delivery through conventional routes. Therefore, further research will focus on the delivery of these complex molecules through different routes, including nasal, pulmonary, vaginal, rectal, etc. The intend of the study was to formulate and evaluate ethosomes of Sesbania grandiflora leaves which may transport the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. Trans-dermal drug delivery is a technique which can be exploited to overcome the variables, which could affect the oral absorption of drugs such as pH, food intake and gastrointestinal motility. As compared to liposome or hydro-alcoholic solution ethosomal systems were much more capable at delivering a fluorescent probe to the skin in terms of quantity and depth. The formulations were prepared with ethanol, lecithin, propylene glycol, and glycerol and were evaluated. The lecithin (phospholipids) used as a vesicles forming component, polyglycol and ethanol used as a skin penetration enhancer. The drug released of formulated ethosomal gel was 4-5 times improved as compared to non ethosomal gel which directly achieves unparalleled flexibility in formulation. Ethosomal gel successfully addresses the issues relating to the drug delivery of poorly water-soluble drugs, peptides, potent drugs and the release of multi-drugs.

Keywords


Sesbania grandiflora, Ethosomes, Bioavailability, Transdermal, Ethosomal-gel, Nano-carrier, novel drug delivery, Diffusion.

References