Open Access
Subscription Access
Open Access
Subscription Access
Estimation of Synergistic Antioxidant Effect of Methanolic Extracts of Some Medicinal Herbs
Subscribe/Renew Journal
Antioxidant activity encompasses protection against cellular wear and tear by interfering in the formation of free radicals. The majority of the diseases are linked to oxidative stress generated due to these free radicals. It makes the basis for plants containing secondary metabolites showing antioxidant activity as the potential source for development of newer formulations showing action against diseases like infections, cancers and other degenerative diseases. The present study involves the study of methanolic extracts of three medicinal herbs cannabis (Cannabis sativa.), wheatgrass (Triticum aestivum) and carrot (Dascus carota L.) commonly available in Indian cultivation. The antioxidant potential of the combination of these extracts was also studied. The combinations showed a synergistic antioxidant activity suggesting that potential of natural plant extracts against any disease can be increased when used in combinations.
Keywords
Antioxidant, Synergistic, Plant extract, Wheat grass, Cannabis, Carrot, Phytochemical.
Subscription
Login to verify subscription
User
Font Size
Information
- Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews. 2010;4(8):118. doi: 10.4103/0973-7847.70902. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
- Muthukumaran P, Shanmuganathan P, Malathi C. In Vitro Antioxidant Evaluation of Mimosa pudica. Asian Journal of Pharmaceutical Research. 2011; 1(2): 44-46. http://www.indianjournals.com/ijor.aspx?target=ijor:ajpr&volume=1&issue=2&article=005
- Pham-Huy LA, Hua H, Pham-Huy C. Free radicals, antioxidants in disease and health. International Journal of Biomedical Science: IJBS. 2008; 4(2): 89. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/
- Samal PK. Antioxidant activity of Strobilanthes asperrimus in albino rats. Asian Journal of Pharmaceutical Research 2013; 3(2): 71-74. http://www.indianjournals.com/ijor.aspx?target=ijor:ajpr&volume=3&issue=2&article=003
- Natividad C, Santiago A, Alias JC. Quantification of the Antioxidant Activity of Plant Extracts: Analysis of Sensitivity and Hierarchization Based on the Method Used. Antioxidants; 2020: 9(1): 76. doi.org/10.3390/antiox9010076. https://www.mdpi.com/2076-3921/9/1/76/htm
- Phaniendra A,Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry. 2015; 30(1):11-26. doi: 10.1007/s12291-014-0446-0. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310837/
- Young IS, Woodside JV. Antioxidants in health and disease. Journal of Clinical Pathology. 2001; 54(3):176-86. doi.org/10.1136/jcp.54.3.176. https://jcp.bmj.com/content/54/3/176
- Jayasri R, Anuradha R. In Vitro Antioxidant and Antibacterial Activity of Boerhaavia diffusa. Research Journal of Pharmacognosy and Phytochemistry. 2012; 4(4): 223-225. http://rjpponline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacognosy%20and%20Phytochemistry;PID=2012-4-4-8
- Manikandan R, Anand A V. A Review on Antioxidant activity of Psidium guajava. Research Journal of Pharmacy and Technology. 2015; 8(3): 339-342. DOI: 10.5958/0974-360X.2015.00056.6 https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2015-8-3-10
- Kathirvel A, Sujatha V. Phytochemical studies, antioxidant activities and identification of active compounds using GC–MS of Dryopteris cochleata leaves. Arabian Journal of Chemistry. 2016; 9: S1435-42. doi.org/10.1016/j.arabjc.2012.03.018 https://www.sciencedirect.com/science/article/pii/S1878535212000640
- Mujeeb F, Bajpai P, Pathak N. Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos. BioMed Research International. 2014; 2014. doi: 10.1155/2014/497606 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037574/
- Tiwari P, Patel RK. Estimation of Total Phenolics and Flavonoids and Antioxidant Potential of Ashwagandharishta Prepared by Traditional and Modern Methods. Asian Journal of Pharmaceutical Analysis.2013; 3(4): 147-152. https://ajpaonline.com/AbstractView.aspx?PID=2013-3-4-9.
- Paul S, Saha D. Pharmacognostic Studies on Methanolic Extract of the Aerial Part of Leucas zeylanica (L). Asian Journal of Pharmaceutical Research 2012: 2(4): 142-143. http://asianjpr.com/AbstractView.aspx?PID=2012-2-4-4
- Valli G, Jeyalakshmi M. Preliminary Phytochemical and Antioxidant Study of Odina woodier Leaf Extract. Asian Journal of Pharmaceutical Analysis. 2012; 2(4): 153-155. https://asianjpr.com/AbstractView.aspx?PID=2012-2-4-4
- Yadav M , Meena AK, Rao MM, Mangal A, Chahal J. Physicochemical and Preliminary Phytochemical Studies On the Leaves of Crinum latifolium Linn. Research Journal of Pharmacognosy and Phytochemistry. 2011; 3(3): 120-123. http://rjptonline.org/HTMLPaper.aspx?Journal=Research+Journal+of+Pharmacognosy+and+Phytochemistry%3bPID%3d2011-3-3-6
- Sharma J, Sharma SC, Sarangdevot YS, Vyas B. Phytochemical Investigation on Stem Bark of Holoptelea integrifolia (Roxb.). Research Journal of Pharmacognosy and Phytochemistry 2012; 4(3): 178-181. https://scholar.google.co.in/scholar?q=Phytochemical+Investigation+on+Stem+Bark+of+Holoptelea+integrifolia+(Roxb.).&hl=en&as_sdt=0&as_vis=1&oi=scholart
- Nariya PB, Bhalodia NR, Shukla VJ, Acharya R, Nariya MB. In vitro evaluation of antioxidant activity of Cordia dichotoma (Forst f.) bark. Ayu. 2013; 34(1): 124. DOI: 10.4103/0974-8520.115451 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764870/
- Truong DH, Nguyen DH, Ta NT, Bui AV, Do TH, Nguyen HC. Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of Severinia buxifolia. Journal of Food Quality. 2019; 2019. doi.org/10.1155/2019/8178294. https://www.hindawi.com/journals/jfq/2019/8178294/
- Batra N, Honey J, Ranjan B, Mukesh B. Pharmacognostical and preliminary phytochemical investigation of Acorus calamus linn. Asian Journal of Pharmaceutical Research. 2012; 2(1): 39-42. https://asianjpr.com/HTMLPaper.aspx?Journal=Asian%20Journal%20of%20Pharmaceutical%20Research;PID=2012-2-1-6
- Bairwa R, Jain H, Shrivastav B. Standardization and phytochemical investigation of Berberis aristata. Asian Journal of Pharmaceutical Analysis. 2012; 2(3): 81-84. https://ajpaonline.com/HTMLPaper.aspx?Journal=Asian%20Journal%20of%20Pharmaceutical%20Analysis;PID=2012-2-3-5
- Ahmed M, Ji M, Qin P, Gu Z, Liu Y, Sikander A. Phytochemical screening, total phenolics and flavonoids content and antilxidant activities of Citrulluscolocynthis L. and Cannabis sativa L. Applied Ecological Environmental Research. 2019; 17: 6961-79. DOI:10.15666/aeer/1703_69616979 http://www.aloki.hu/pdf/1703_69616979.pdf
- Kogan NM, Mechoulam R. Cannabinoids in health and disease. Dialogues in clinical neuroscience. 2007; 9(4): 413. doi: 10.31887/DCNS.2007.9.4/nkogan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504/
- Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutrition Journal. 2015; 15(1): 71. doi: 10.1186/s12937-016-0186-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960740/
- Kaur V, Kumar M, Kumar A, Kaur K, Dhillon VS, Kaur S. Pharmacotherapeutic potential of phytochemicals: Implications in cancer chemoprevention and future perspectives. Biomedicine & Pharmacotherapy. 2018; 97: 564-86. doi: 10.1016/j.biopha.2017.10.124. https://www.sciencedirect.com/science/article/abs/pii/S075333221733130X
- Kooti W, Servatyari K, Behzadifiar, Asadi-Samani M, Sadeghi F, Nouri B, Marzouni HZ. Effective Medicinal Plants in Cancer Treatment, Part 2: Review Study. Journal of Evidence Based Complementary Alternative Medicine. 2017; 22(4): 982–995. doi: 10.1177/2156587217696927. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871268/
- Indian Pharmacopeia, Ministry of Health and Family Welfare, Govt. of India.IP 2010; 201-205
- https://www.sigmaaldrich.com/catalog/product/cerillian/t005?lang=en®ion=IN
- Ruch RJ, Crist KA, Klaunig JE. Effects of culture duration on hydrogen peroxide-induced hepatocyte toxicity. Toxicology and Applied Pharmacology. 1989; 100(3): 451-64. doi: 10.1016/0041-008x(89)90293-7
- Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews. 2010; 4(8):118. doi: 10.4103/0973-7847.70902 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
- Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative Stress and Antioxidant Defense. World Allergy Organ Journal. 2012; 5(1): 9–19. doi: 10.1097/WOX.0b013e3182439613. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488923/
- Tvrdá E, Benko F. Free radicals: what they are and what they do In Pathology Oxidative Stress and Dietary Antioxidants 2020; 3-13. doi: 10.4103/0973-7847.70902. https://www.sciencedirect.com/topics/nursing-and-health-professions/hydroxyl-radical
- Li Y, Trush MA, Yager JD. DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol. Carcinogenesis. 1994; 15(7): 1421-7. doi: 10.1093/carcin/15.7.1421. https://www.ncbi.nlm.nih.gov/pubmed/8033320
- El-Haci IA, Bekkara FA, Mazari W, Hassani F, Didi MA. Screening of biological activities of Polygonum maritimum L. from Algerian coast. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(8): 611. doi: 10.1016/S2221-1691(13)60124-0
- https://www.sciencedirect.com/science/article/abs/pii/S2221169113601240 34. Wink M. Modes of action of herbal medicines and plant secondary metabolites. Medicines. 2015; 2(3):251-86. doi: 10.3390/medicines2030251. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456217/
- Daramola B. Preliminary investigation on antioxidant interactions between bioactive components of Solanum anguivi and Capsicum annuum. Journal of Food Science and Technology. 2018; 55(9): 3827-32. doi.org/10.1007/s13197-018-3267-y. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098784/
Abstract Views: 160
PDF Views: 0