Research Journal of Pharmacy and Technology

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Lovastatin Loaded Solid Lipid Nanoparticles for Transdermal Delivery: In Vitro Characterization


Affiliations
1 Saras College of Pharmacy, Baghpat, Uttar Pradesh, 250622,, India
2 Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh 247121,, India
3 Department of Pharmaceutics, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad, Uttar Pradesh 201206,, India
     

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Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The results reveal that the optimized SLNs are spherical, with a smooth surface and having particle size 298±1.1 nm, the PDI and zeta potential of optimized formulation was 0.42±0.09 and -19.1±0.81 MeV, respectively, the percent drug loading was 49.81±0.87. The optimized formulation follows Higuchi’s kinetics for drug release.

Keywords

Lovastatin, Zeta potential, Solid lipid nanoparticles.
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  • Lovastatin Loaded Solid Lipid Nanoparticles for Transdermal Delivery: In Vitro Characterization

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Authors

Dinesh Kumar Gupta
Saras College of Pharmacy, Baghpat, Uttar Pradesh, 250622,, India
Satish Kumar Sharma
Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh 247121,, India
Praveen Kumar Gaur
Department of Pharmaceutics, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad, Uttar Pradesh 201206,, India
Alok Pratap Singh
Department of Pharmaceutics, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad, Uttar Pradesh 201206,, India

Abstract


Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The results reveal that the optimized SLNs are spherical, with a smooth surface and having particle size 298±1.1 nm, the PDI and zeta potential of optimized formulation was 0.42±0.09 and -19.1±0.81 MeV, respectively, the percent drug loading was 49.81±0.87. The optimized formulation follows Higuchi’s kinetics for drug release.

Keywords


Lovastatin, Zeta potential, Solid lipid nanoparticles.

References