Research Journal of Pharmacy and Technology

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The Metabolic Effects of Coenzyme Q10 in Patients with Polycystic Ovary Syndrome


Affiliations
1 College of Pharmacy, University of Mosul, Mosul,, Iraq
2 Al-Salam Teaching Hospital, Nineveh Health Directorate, Ministry of Health,, Iraq
     

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There is a lack of evidence on the metabolic effect of coenzyme Q10 administration in women with polycystic ovary syndrome (PCOS). The present study aimed to investigate the influence of CoQ10 on glycemic control markers and lipid parameters in PCOS. The study employed a double-blind, placebo-controlled design. A total of 100 subjects with PCOS were enrolled. Subjects were randomly enrolled into 2 groups. The intervention group had received 200 mg CoQ10 supplements once daily (N = 50) and the control group had received corn starch (N = 50). The duration of treatment was three months for both groups. Fasting serum glucose, insulin levels and lipid parameters were recorded before and at the end of the study. After 3 months of intervention, patients whom receiving CoQ10 therapy (200mg/day) had significantly lower levels of fasting serum glucose, glycated hemoglobin, serum total cholesterol, low density lipoprotein cholesterol, and triglycerides were found between CoQ10-supplemented compared to placebo-treated women. Overall, three months of CoQ10 supplementation had a beneficial effect on glucose metabolism, lipid profile and atherogenic index in women with PCOS.

Keywords

Coenzyme Q10, Glycemic control, Lipid profile, PCOS.
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  • Pahari SK, Ghosh S, Halder S, Jana M. Role of Coenzyme Q10 in human life. Research Journal of Pharmacy and Technology. 2016;9(6):635-40. doi.org/10.5958/0974-360X.2016.00121.9

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  • Zhang SY, Yang KL, Zeng LT, Wu XH, Huang HY. Effectiveness of coenzyme Q10 supplementation for type 2 diabetes mellitus: a systematic review and meta-analysis. International Journal of Endocrinology. 2018 Sep 16;2018.

  • Samimi M, Zarezade Mehrizi M, Foroozanfard F, Akbari H, Jamilian M, Ahmadi S, Asemi Z. The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial. Clinical Endocrinology. 2017 Apr;86(4):560-6.

  • Sharifi N, Tabrizi R, Moosazadeh M, Mirhosseini N, Lankarani KB, Akbari M, Chamani M, Kolahdooz F, Asemi Z. The effects of coenzyme Q10 supplementation on lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Current Pharmaceutical Design. 2018 Jun 1;24(23):2729-42.

  • Hosseinzadeh-Attar MJ, Eshraghian MR, Nakhjavani M, Khorami E, Esteghamati A. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterologica e Dietologica. 2013 Jun 1;59(2):231-6.

  • Zahedi H, Eghtesadi S, Seifirad S, Rezaee N, Shidfar F, Heydari I, Golestan B, Jazayeri S. Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: a randomized, double blind, placebo-controlled trial. Journal of Diabetes & Metabolic Disorders. 2014 Dec;13(1):1-8.

  • Al-Thanoon ZA, Al-Youzbaki WB. Serum leptin and testosterone level and insulin sensitivity in patients with polycystic ovary syndrome treated by metformin. Pharmacie Globale. 2012 Dec 1;3(12):1.


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  • The Metabolic Effects of Coenzyme Q10 in Patients with Polycystic Ovary Syndrome

Abstract Views: 156  |  PDF Views: 0

Authors

Shahad A. Bader
College of Pharmacy, University of Mosul, Mosul,, Iraq
Zeina A. Althanoon
College of Pharmacy, University of Mosul, Mosul,, Iraq
Hiba S. Raoof
Al-Salam Teaching Hospital, Nineveh Health Directorate, Ministry of Health,, Iraq

Abstract


There is a lack of evidence on the metabolic effect of coenzyme Q10 administration in women with polycystic ovary syndrome (PCOS). The present study aimed to investigate the influence of CoQ10 on glycemic control markers and lipid parameters in PCOS. The study employed a double-blind, placebo-controlled design. A total of 100 subjects with PCOS were enrolled. Subjects were randomly enrolled into 2 groups. The intervention group had received 200 mg CoQ10 supplements once daily (N = 50) and the control group had received corn starch (N = 50). The duration of treatment was three months for both groups. Fasting serum glucose, insulin levels and lipid parameters were recorded before and at the end of the study. After 3 months of intervention, patients whom receiving CoQ10 therapy (200mg/day) had significantly lower levels of fasting serum glucose, glycated hemoglobin, serum total cholesterol, low density lipoprotein cholesterol, and triglycerides were found between CoQ10-supplemented compared to placebo-treated women. Overall, three months of CoQ10 supplementation had a beneficial effect on glucose metabolism, lipid profile and atherogenic index in women with PCOS.

Keywords


Coenzyme Q10, Glycemic control, Lipid profile, PCOS.

References