Research Journal of Pharmacy and Technology

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Effect of Zinc as an Add-on to Metformin Therapy on Glycemic Control, Serum Insulin, and C-peptide Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patient


Affiliations
1 Alssalam Teaching Hospital, Ninevah Health Directorate, Mosul,, Iraq
2 College of Medicine, University of Mosul, Mosul,, Iraq
3 College of Medicine, Ninevah University, Mosul,, Iraq
4 College of Pharmacy, Ninevah University, Mosul,, Iraq
     

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Type 2 diabetes mellitus (T2DM) is an insidious disorder that may progress asymptomatically, leading to secondary complications. Diabetics were found to have a significantly lower zinc level. This study aims to assess the effects of zinc supplementation for eight weeks on glycemic control, serum insulin level, serum C-peptide level, and insulin resistance. Zinc plus metformin using group had a significant decrease in fasting blood glucose level and glycated hemoglobin, as well as a significant increase in serum insulin and C-peptide levels, but no effect on insulin resistance compared to zinc-free metformin group. Comparing the two groups at the end of the study, the combined effect of zinc plus metformin was highly important versus metformin only except for C-peptide and insulin resistance. Zinc levels were significantly elevated and returned to normal in the interventional group, while in the control group, levels were rather decreased.

Keywords

Glycemic, Insulin, Metformin, Zinc, Diabetes.
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  • Effect of Zinc as an Add-on to Metformin Therapy on Glycemic Control, Serum Insulin, and C-peptide Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patient

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Authors

Hend Y. Younis
Alssalam Teaching Hospital, Ninevah Health Directorate, Mosul,, Iraq
Imad A. Thanoon
College of Medicine, University of Mosul, Mosul,, Iraq
Nabeel N. Fadhil
College of Medicine, Ninevah University, Mosul,, Iraq
Marwan M. Merkhan
College of Pharmacy, Ninevah University, Mosul,, Iraq

Abstract


Type 2 diabetes mellitus (T2DM) is an insidious disorder that may progress asymptomatically, leading to secondary complications. Diabetics were found to have a significantly lower zinc level. This study aims to assess the effects of zinc supplementation for eight weeks on glycemic control, serum insulin level, serum C-peptide level, and insulin resistance. Zinc plus metformin using group had a significant decrease in fasting blood glucose level and glycated hemoglobin, as well as a significant increase in serum insulin and C-peptide levels, but no effect on insulin resistance compared to zinc-free metformin group. Comparing the two groups at the end of the study, the combined effect of zinc plus metformin was highly important versus metformin only except for C-peptide and insulin resistance. Zinc levels were significantly elevated and returned to normal in the interventional group, while in the control group, levels were rather decreased.

Keywords


Glycemic, Insulin, Metformin, Zinc, Diabetes.

References