Research Journal of Pharmacy and Technology

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A Review on Pulsatile Drug Delivery System: Drug Scheduling Based on Biological Rhythm


Affiliations
1 Research Scholar, Grace College of pharmacy, Palakkad, Kerala-678004,, India
2 Professor, Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala-678004,, India
3 Principal, Grace College of Pharmacy, Palakkad, Kerala-678004,, India
     

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Advancement in chronopharmacology and the necessity of an appropriate technology for time specific and site specific drug delivery has led to the development of novel type of drug delivery systems as “chronotropic or Pulsatile drug delivery systems”. Rationale for designing pulsatile delivery systems is to release the drug at desired time, which results in improved therapeutic efficacy and patient-outcome. These systems are meant for treatment of those diseases that are caused due to circadian changes in body like asthma, peptic ulcer, cardiovascular diseases, arthritis and when zero order drug release is not desired. These pulsatile delivery systems a releases the drug within a short period of time, immediately after a predetermined lag time. The present article focuses on diseases requiring chronotropic systems and their chronological behaviour, various approaches, recent technologies for chronotherapy and currently available marketed formulations.

Keywords

Chronotherapy, Circadian rhythm, Pulsatile drug delivery system, Time controlled chronotropic systems, Stimuli induced pulsatile drug delivery systems.
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  • A Review on Pulsatile Drug Delivery System: Drug Scheduling Based on Biological Rhythm

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Authors

Amritha R
Research Scholar, Grace College of pharmacy, Palakkad, Kerala-678004,, India
Sivakumar R
Professor, Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala-678004,, India
Y. Haribabu
Principal, Grace College of Pharmacy, Palakkad, Kerala-678004,, India

Abstract


Advancement in chronopharmacology and the necessity of an appropriate technology for time specific and site specific drug delivery has led to the development of novel type of drug delivery systems as “chronotropic or Pulsatile drug delivery systems”. Rationale for designing pulsatile delivery systems is to release the drug at desired time, which results in improved therapeutic efficacy and patient-outcome. These systems are meant for treatment of those diseases that are caused due to circadian changes in body like asthma, peptic ulcer, cardiovascular diseases, arthritis and when zero order drug release is not desired. These pulsatile delivery systems a releases the drug within a short period of time, immediately after a predetermined lag time. The present article focuses on diseases requiring chronotropic systems and their chronological behaviour, various approaches, recent technologies for chronotherapy and currently available marketed formulations.

Keywords


Chronotherapy, Circadian rhythm, Pulsatile drug delivery system, Time controlled chronotropic systems, Stimuli induced pulsatile drug delivery systems.

References