Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Herbal Treatment for Management of Psoriasis: An Overview


Affiliations
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra – 416013, India
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra – 416013., India
     

   Subscribe/Renew Journal


Psoriasis is an inflammatory skin condition characterised by scaling with inflammation (pain, edema, warmth, and redness) that results in regions of thick, red skin covered in silvery scales. These spots can be itchy or painful. Systemic treatment, topical therapy, and phototherapy are all now used to treat psoriasis. These treatments have a variety of negative and perhaps fatal side effects. Patients with psoriasis are more likely to acquire other conditions such as psoriatic arthritis, anxiety and depression, cancer, metabolic syndrome, cardiovascular disease, and Crohn's disease. The majority of people use herbal medicine because it is readily available, inexpensive, and effective. Many plants have promising features, including significant results in the treatment of psoriasis. The present study plans to emphasize such plants, herbal formulations, and associated therapy, which could add value to the development of a better, safe, and efficacious formulation to treat psoriasis that may help new researchers in this field.

Keywords

Psoriasis, autoimmune disease, medicinal plants, herbal formulation, topical therapy.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Krueger JG, The immunologic basis for the treatment of psoriasis with new biologic agents, Journal of American Academy of Dermatology. 2002; 46: 1–23. doi:10.1067/mjd.2002.120568

  • Sumithra M, Mohamed A, Chitra. V. Cell lines and animal models of psoriasis. Research Journal of Pharmacy and Technology. 2020; 13(3):1601-1608. doi: 10.5958/0974-360X.2020.00290.5

  • Jobling R, A patient’s journey, Psoriasis. British Medical Journal. 2007; 334:953-954. doi: 10.1136/bmj.39184.615150.802

  • DiPiro JT. Pharmacotherapy Handbook. Wells BG, Schwinghammer TL, DiPiro CV, Education MH, editors. Appleton & Lange; 2000.

  • Bissonnette R, Fuentes DJ, Mashiko S, Li X, Bonifacio KM, Cueto I, Suárez FM, Maari C, Bolduc C, Nigen S, Sarfati M. Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway. Journal of Dermatological Science. 2017; 85(1):20-6. doi:10.1016/j.jdermsci.2016.09.019

  • Farber EM, Nall ML, Watson W. Natural history of psoriasis in 61 twin Pairs. Archives of Dermatol. 1974; 109:207–211. doi:10.1001/archderm.1974.01630020023005.

  • Mallon E, Bunce M, Savoie H, Rowe A, Newson R, Gotch F, Bunker CB. HLA‐C and guttate psoriasis. British Journal of Dermatology. 2000; 143(6):1177-82. doi: 10.1046/j.1365-2133.2000.03885.x

  • Gudjonsson JE, Karason A, Antonsdottir A, Runarsdottir E, Hauksson VB, Upmanyu R, Gulcher J, Stefansson K. and Valdimarsson H. Psoriasis patients who are homozygous for the HLA‐Cw 0602 allele have a 2· 5‐fold increased risk of developing psoriasis compared with Cw6 heterozygotes. British Journal of Dermatology. 2003; 148(2):233-235. doi:10.1046/j.1365-2133.2003.05115.x

  • Elder JT. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. Genes & Immunity. 2009; 10(3):201-9. doi:10.1038/gene.2009.11

  • Sakthi PS, Vani PB, Kumar PR. A comparative review on conventional and traditional medicine in the treatment of psoriasis. Research Journal of Pharmacy and Technology. 2020; 13(11):5642-5646. doi:10.5958/0974-360X.2020.00983.X

  • Yin X, Low HQ, Wang L, Li Y, Ellinghaus E, Han J, Estivill X, Sun L, Zuo X, Shen C, Zhu C. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nature communications. 2015; 23; 6(1):1-1. doi: 10.1038/ncomms7916

  • Deka D, Borah T, Swarnakar A, Baruah D, Bharali BK. Psoriasis: A comparative study as per ayurvedic and modern classics. Journal of Ayurvedic and Herbal Medicine. 2016; 2: 186-191.

  • Haslett C, Haslett C, Davidson SS. Davidson's principles and practice of medicine. Churchill Livingstone; 2002.

  • Padmini IR, Gupta VN. Formulation and evaluation of herbal cream for treating psoriasis. Research Journal of Pharmacy and Technology. 2021; 14(1):167-170. doi: 10.5958/0974-360X.2021.00029.9

  • Kulkarni UM, Shetty YC, Dongre AM, Dave JS, Khopkar US. The perception of dermatologists towards the outcome of ayurvedic therapy for psoriasis. Journal of Clinical & Experimental Dermatology Research. 2018; 9(465):2. doi: 10.4172/2155-9554.1000465

  • Menter A, Griffiths CE, Current and future management of psoriasis, Lancet. 2007; 370:272–284. doi:10.1016/S0140-6736(07)61129-5

  • Qavami N, Naghdi BH, Labbafi MR, Mehrafarin A. A review on pharmacological, cultivation and biotechnology aspects of milk thistle Silybum marianum L. Gaertn. Journal of Medicinal Plants. 2013; 12(47):19-37.

  • Khedekar YB, Mojad AA, Malsane PN. Formulation, development, and evaluation of silymarin loaded topical gel for fungal infection. International Journal of Advances in Pharmaceutics. 2019; 08(01): e5041. doi: https://doi.org/10.7439/ijap.v8i1.5041

  • Khan PA, Thube R, Rab RA, Formulation development and evaluation of silymarin gel for psoriasis treatment, Journal of Innovations in Pharmaceuticals and Biological Sciences. 2013; 1(1):021-026.

  • Singh KK, Tripathy S. Natural treatment alternative for psoriasis: a review on herbal resources. Journal of Applied Pharmaceutical Science. 2014; 4(11):114-21. doi: 10.7324/JAPS.2014.41120

  • Svobodová AR, Zálešák B, Biedermann D, Ulrichová J, Vostálová J. Phototoxic potential of silymarin and its bioactive components. Journal of Photochemistry and Photobiology B: Biology. 2016; 1; 156:61-8. doi:10.1007/s00403-018-1828-6

  • Lokesh B, Deepa R, Divya K. Medicinal Coleus (Coleus forskohlii Briq): A phytochemical crop of commercial significance. Journal of Pharmacognosy and Phytochemistry. 2018; 7:2856-64. doi:10.1016/j.phytochem.2018.08.003

  • Damle MC, Bhalekar MR, Lonkar SA, Formulation and evaluation of herbal gel for the treatment of psoriasis, World Journal of Pharmacy and Pharmaceutical Sciences. 2017; 6(7):1199-1210. doi: 10.20959/wjpps20177-9521.

  • Manikannan M, Arumugam S, Rangasamy B, Selvaraj J. Immune Stimulation effects of Pongamia pinnata extracts an in vitro analysis. Research Journal of Pharmacy and Technology. 2020; 13(1): 308-312. doi: 10.5958/0974-360X.2020.00062.1

  • Chopade VV, Tankar AN, Pande VV, Tekade AR, Gowekar NM, Bhandari SR, Khandake SN. Pongamia pinnata: phytochemical constituents, traditional uses and pharmacological properties: a review. International Journal of Green Pharmacy. 2008; 2(2):72-75.

  • Alex T, Mansuri S, Chaudhary S, Malviya N, Evaluation of anti psoriatic activity of karanjin oil, Journal of Drug Delivery and Therapeutics. 2017; 7(7):206-207. doi: https://doi.org/10.22270/jddt.v7i7.1638

  • Salunke PB, Kadam SS, Patil SB, Kolap MB, Antipsoriatic activity of gel containing methylsulphonylmethane powder and seed oil of pongamia pinnata Linn, Der Pharma Chemica. 2017; 9(18):12-20.

  • Divakara P, Nagaraju B, Buden RP, Sekhar HS, Ravi CM. Antipsoriatic activity of ayurvedic ointment containing aqueous extract of the bark of Pongamia pinnata using the rat ultraviolet ray photodermatitis model. Advancement in Medicinal Plant Research. 2013; 1:8-16.

  • Ghosh A, Tiwari GJ. Role of nitric oxide-scavenging activity of karanjin and pongapin in the treatment of psoriasis. Biotech. 2018; 8(8):1-4. doi:org/10.1007/s13205-018-1337-5

  • Hiteksha SP, Mamta BS. Thespesia populnea linn. A review. International Journal of Pharmacognosy. 2017; 4(1):1-05. doi:10.13040/IJPSR.0975-8232.IJP.4(1).1-05

  • Shrivastav S, Sindhu RK, Kumar S, Kumar P, Anti-Psoriatic and phytochemical evaluation of thespesia populnea bark extracts, International Journal of Pharmacy and Pharmaceutical Sciences. 2009; 1(1):176-185.

  • Abi PK, Madhusudhanan K. Memecylon malabaricum Cogn, plant profile, pharmacology and phytochemistry-a review. International Journal of Biosciences, Alternative and Holistic Medicine. 2017; 5(1):1.

  • Dhanabal SP, Muruganantham N, Basavaraj KH, Wadhwani A, Shamasundar NM. Antipsoriatic activity of extracts and fractions obtained from Memecylon Malabaricum leaves. Journal of Pharmacy and Pharmacology. 2012; 64(10):1501-9.

  • Vijayalakshmi A, Madhira G. Anti-psoriatic activity of flavonoids from Cassia tora leaves using the rat ultraviolet B ray photodermatitis model. Revista Brasileira de Farmacognosia. 2014; 1; 24(3):322-9. doi: http://dx.doi.org/ 10.1016/j.bjp.2014.07.010

  • Singhal M, Kansara N. Cassia tora Linn cream inhibits ultraviolet-B-induced psoriasis in rats. International Scholarly Research Notices. 2012; 1-6. doi:10.5402/2012/346510

  • Geetha M, Vijayalakshmi A. Pharmacognostic and phytochemical investigation of Givotia rottleriformis Griff. Ex Wight bark. Journal of Pharmacognosy and Phytochemistry. 2013; 2(3):188-94.

  • Niper J. Anti-Psoriatic activity of flavonoids from the bark of Givotia rottleriformis Griff. Ex Wight. Iranian Journal of Pharmaceutical Sciences. 2014; 10(3):81-94.

  • Vijayalakshmi A, Geetha M. Anti-psoriatic activity of Givotia rottleriformis in rats. Indian journal of pharmacology. 2014; 46(4):386. doi:10.4103/0253-7613.135949

  • Dhanabal SP, Raj BA, Muruganantham N, Praveen TK, Raghu PS. Screening of Wrightia tinctoria leaves for anti psoriatic activity. Hygeia-Journal for Drugs and Medicine. 2012; 4(1):73-8.

  • Singh D, Rawat S, Riyal N, Aman S, Khulbe P. Determining anti-psoriatic activity of salicylic acid and wrightia tinctoria herb using extemporaneous formulation. 2018; 7 (4): 562-585.

  • Iriventi P, Gupta NV. Development and evaluation of nanosponge loaded topical herbal gel of wrightia tinctoria. International Journal of Applied Pharmaceutics. 2020; 15:89-95.

  • Takuathung MN, Wongnoppavich A, Pitchakarn P, Panthong A, Khonsung P, Chiranthanut N, Soonthornchareonnon N, Sireeratawongs S, Effects of wannachawee recipe with antipsoriatic activity on suppressing inflammatory cytokine production in HaCaT human keratinocytes, Hindawi Evidence-Based Complementary and Alternative Medicine. 2017; 1-12. doi: doi.org/10.1155/2017/5906539

  • Shalini K, Aleykutty NA, Harindran J. In vitro antipsoriatic effect of extract of Strobilianthes ciliatus using Hacat cell lines and its cyclooxygenase inhibition using RAW 264.7 cell lines. The Pharma Innovation Journal. 2018; 7(3): 253-256.

  • Parmar KM, Itankar PR, Joshi A, Prasad SK. Anti-psoriatic potential of Solanum xanthocarpum stem in imiquimod-induced psoriatic mice model. Journal of Ethnopharmacology. 2017; 23; 198:158-66.

  • Suryawanshi JS. An overview of Citrus aurantium used in treatment of various diseases. African Journal of Plant Science. 2011; 5(7):390-5.

  • Vardhan TV, Kumar M, Arumugam P. Anti-psoriatic activity of orange peel extract using monocytic cell line. 2015; 8(3):119-129.

  • Kumar BV, Sekhar GC, Venkatesh C, Manikanta Y, Nagalakshmi J, Rao NR. Phytochemical screening and anti-psoriatic evaluation of citrus sinensis peel extracts on mouse tail model. World Journal of Pharmaceutical Research. 2019; 8(2):1210-1219. doi:10.20959/wjpr20192-14147

  • Yadav D, Yadav SK, Khar RK, Mujeeb M, Akhtar M. Turmeric (Curcuma longa L.): A promising spice for phytochemical and pharmacological activities. International Journal of Green Pharmacy. 2013; 7(2):85-89. doi:10.4103/0973-8258.116375

  • Ashraf K, Sulatan S, A comprehensive review on Curcuma longa Linn. Phytochemical, pharmacological, and molecular study. International Journal of Green Pharmacy. 2018; 11; 11(04).S671-S685. doi: http://dx. doi.org/10.22377/ijgp.v11i04.1343

  • Miquel J, Bernd A, Sempere JM, Dıaz-Alperi J, Ramırez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Archives of Gerontology and Geriatrics. 2002; 1; 34(1):37-46. doi:10.1016/s0167-4943(01)00194-7.

  • Badmanaban R, Saha D, Sen DJ Biswas A, Mandal S, Basak S. Turmeric: A holistic solution for biochemical malfunction. Research Journal of Pharmacy and Technology. 2021; 14(10):5540-0. doi:10.52711/0974-360X.2021.00966

  • Morankar PG, Kumbhare MR, Shelke SJ, Diwane CM. Enhancement of skin permeability and anti-inflammatory, antipsoriatic efficacy of curcumin through a gel formulation. Innoriginal: International Journal of Sciences. 2021; 28:22-9.

  • Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M, Diederich M. Chemopreventive and therapeutic effects of curcumin. Cancer letters. 2005; 8; 223(2):181-90. doi: 10.1016/j.canlet.2004.09.041.

  • Iriventi P, Gupta NV, Osmani RA, Balamuralidhara V. Design & development of nanosponge loaded topical gel of curcumin and caffeine mixture for augmented treatment of psoriasis. DARU Journal of Pharmaceutical Sciences. 2020; 29:1-8. doi:10.1007/s40199-020-00352-x

  • Hassan BA. Evaluation of Antipsoriatic activity of topical curcumin by using mouse tail model. University of Thi-Qar Journal of Medicine. 2018; 16(2):172-84.

  • Scomoroscenco C, Teodorescu M, Raducan A, Stan M, Voicu SN, Trica B, Ninciuleanu CM, Nistor CL, Mihaescu CI, Petcu C, Cinteza LO. Novel gel microemulison as topical drug delivery system for curcumin in dermatocosmetics. Pharmaceutics. 2021; 13(4):505.

  • Jin N, Lin J, Yang C, Wu C, He J, Chen Z, Yang Q, Chen J, Zheng G, Lv L, Liang H. Enhanced penetration and anti-psoriatic efficacy of curcumin by improved smartPearls technology with the addition of glycyrrhizic acid. International journal of pharmaceutics. 2020; 30; 578:119101. doi: 10.1016/j.ijpharm.2020.119101.

  • Hashmat I, Azad H, Ahmed A. Neem Azadirachta indica (A. Juss) a nature’s drugstore: an overview. International Research Journal of Biological Sciences. 2012; 1(6):76-9.

  • Khan S, Mulla G, Bhise K. Development and characterization of topical nanoparticulate antipsoriatic polyherbal cream. International Journal of Applied Pharmaceutics. 2020:7:67-73.

  • Mundada AS, Mahajan MS, Gangurde HH, Borkar VS, Gulecha VS, Khandare RA. Formulation and evaluation of polyherbal antipsoriatic cream. Pharmacology online. 2009; 2:1185-91.

  • Mrowietz U, Kragballe K, Reich K, Spuls P, Griffiths CE, Nast A, Franke J, Antoniou C, Arenberger P, Balieva F, Bylaite M. Definition of treatment goals for moderate to severe psoriasis: a European consensus. Archives of Dermatological Research. 2011; 303(1):1-10.


Abstract Views: 90

PDF Views: 0




  • Herbal Treatment for Management of Psoriasis: An Overview

Abstract Views: 90  |  PDF Views: 0

Authors

Ravindra G. Gaikwad
Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra – 416013, India
Anilkumar J. Shinde
Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra – 416013., India
Ashok A. Hajare
Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra – 416013, India

Abstract


Psoriasis is an inflammatory skin condition characterised by scaling with inflammation (pain, edema, warmth, and redness) that results in regions of thick, red skin covered in silvery scales. These spots can be itchy or painful. Systemic treatment, topical therapy, and phototherapy are all now used to treat psoriasis. These treatments have a variety of negative and perhaps fatal side effects. Patients with psoriasis are more likely to acquire other conditions such as psoriatic arthritis, anxiety and depression, cancer, metabolic syndrome, cardiovascular disease, and Crohn's disease. The majority of people use herbal medicine because it is readily available, inexpensive, and effective. Many plants have promising features, including significant results in the treatment of psoriasis. The present study plans to emphasize such plants, herbal formulations, and associated therapy, which could add value to the development of a better, safe, and efficacious formulation to treat psoriasis that may help new researchers in this field.

Keywords


Psoriasis, autoimmune disease, medicinal plants, herbal formulation, topical therapy.

References