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Formulation and Evaluation of Chronomodulated Pulsatile Drug Delivery System for Nocturnal Hyperacidity


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1 Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
     

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Introduction: Chronomodulated pulsatile drug delivery system is basically time-controlled drug delivery system in which the release of drug in the body is allowed to match with circadian rhythm with controlled lag time. Aim and Objective: The objective of this work was to develop and evaluate oral pulsatile tablet of Pantoprazole sodium for the treatment of nocturnal hyperacidity. Pulsatile drug delivery system for Pantoprazole sodium was formulated initially as a core tablet followed by press coated. Five different compositions of the core tablet were prepared by using cross carmellose super disintegrant. Base on drug content and dissolution time F5 formulation optimised and proceeds for press coating. Five different compositions of press coating were prepared and evaluated for in vitro drug release. Result: The formulation C4 achieved a maximum of 99.65% cumulative drug release over a period of 3hr. 30 min. Lag time for C4 formulation was found to be 2 hr. It means that the system was found to be satisfactory in terms of drug release after a lag time. Conclusion: Since the developed formulation when taken at bedtime, the tablet would be expected to release the drug at midnight which provides better control with the nocturnal hyperacidity.

Keywords

Pulsatile drug delivery, Nocturnal hyperacidity, Chronomodulated drug design, Pantoprazole
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  • Formulation and Evaluation of Chronomodulated Pulsatile Drug Delivery System for Nocturnal Hyperacidity

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Authors

Rohini Kharwade
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Haripriya Nair
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Dipali Masurkar
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Ajay Pise
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Sachin More
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Shilpa Pise
Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India

Abstract


Introduction: Chronomodulated pulsatile drug delivery system is basically time-controlled drug delivery system in which the release of drug in the body is allowed to match with circadian rhythm with controlled lag time. Aim and Objective: The objective of this work was to develop and evaluate oral pulsatile tablet of Pantoprazole sodium for the treatment of nocturnal hyperacidity. Pulsatile drug delivery system for Pantoprazole sodium was formulated initially as a core tablet followed by press coated. Five different compositions of the core tablet were prepared by using cross carmellose super disintegrant. Base on drug content and dissolution time F5 formulation optimised and proceeds for press coating. Five different compositions of press coating were prepared and evaluated for in vitro drug release. Result: The formulation C4 achieved a maximum of 99.65% cumulative drug release over a period of 3hr. 30 min. Lag time for C4 formulation was found to be 2 hr. It means that the system was found to be satisfactory in terms of drug release after a lag time. Conclusion: Since the developed formulation when taken at bedtime, the tablet would be expected to release the drug at midnight which provides better control with the nocturnal hyperacidity.

Keywords


Pulsatile drug delivery, Nocturnal hyperacidity, Chronomodulated drug design, Pantoprazole

References