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The Hypoglycemic and Hypolipidemic Effect of 5- Naphthalidin-2, 4 Thiazolidinedione Derivatives in Alloxan Induced Type Ii Diabetic Model


Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore, Karnataka, India
2 Department of Pharmaceutics, Dr. Ravi Patil College of Pharmacy, Belgaum, Karnataka,, India
     

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Objective: The present study was undertaken to study antidiabetic and antihyperlipidemic potentials of 5- naphthalidin-2, 4-thiazolidinediones derivatives and its interaction with rosiglitazone in alloxan-induced diabetic rats. Methods: Diabetes was induced in male swiss albino rats by single intramuscular injection of alloxan (0.15 mg/Kg i.m) and NIDDM-rats received 4b, 4c or 4d (36 mg/Kg, p.o). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by Duncan's Multiple Range Test (DMRT). Results: The results revealed that 4b, 4c and 4d showed promising results by lowering the blood glucose. Moreover, 4c compound displayed high efficiency for lowering lipid profiles compared to others. Conclusion: These results suggest that taking 5- naphthalidin-2, 4 TZD orally twice/day is a valuable treatment for Non insulin dependent diabetes mellitus (NIDDM) and hypolipidemic agent. They exert their effects through altering regulation genes in glucose and lipid metabolisms in diabetic rats.

Keywords

Diabetes, Free radical scavenging activity, RIN-5F cells, Diseased human lung fibroblast.
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  • The Hypoglycemic and Hypolipidemic Effect of 5- Naphthalidin-2, 4 Thiazolidinedione Derivatives in Alloxan Induced Type Ii Diabetic Model

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Authors

Rekha. S
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore, Karnataka, India
Kalpana Divekar
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore, Karnataka, India
Chandrashekhara. S
Department of Pharmaceutics, Dr. Ravi Patil College of Pharmacy, Belgaum, Karnataka,, India

Abstract


Objective: The present study was undertaken to study antidiabetic and antihyperlipidemic potentials of 5- naphthalidin-2, 4-thiazolidinediones derivatives and its interaction with rosiglitazone in alloxan-induced diabetic rats. Methods: Diabetes was induced in male swiss albino rats by single intramuscular injection of alloxan (0.15 mg/Kg i.m) and NIDDM-rats received 4b, 4c or 4d (36 mg/Kg, p.o). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by Duncan's Multiple Range Test (DMRT). Results: The results revealed that 4b, 4c and 4d showed promising results by lowering the blood glucose. Moreover, 4c compound displayed high efficiency for lowering lipid profiles compared to others. Conclusion: These results suggest that taking 5- naphthalidin-2, 4 TZD orally twice/day is a valuable treatment for Non insulin dependent diabetes mellitus (NIDDM) and hypolipidemic agent. They exert their effects through altering regulation genes in glucose and lipid metabolisms in diabetic rats.

Keywords


Diabetes, Free radical scavenging activity, RIN-5F cells, Diseased human lung fibroblast.

References