Research Journal of Pharmacy and Technology

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Drug Delivery through Osmotic Micropump - a Review


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1 Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, India
     

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This review article discusses the drug delivery systems using osmotic principles for pumping and some of the milestones in Osmotic Drug Delivery (ODDs) systems developed till date. Recent technological advances led to the development of low flow rate biocompatible micropumps. Drug delivery methods are considered as one of the salient characteristic feature to enhance efficacy of a drug. Micropumps help in achieving this by controlled drug delivery which is not possible in traditional methods (tablets and injections). Osmotic systems further increases the patient compliance, decreases dose related adverse events and most importantly helps in controlling or constant drug release (zero-order). Drug release from these systems is independent of pH and other physiological parameters to a large extent. Based on the potential advantages and persistent market demand for new technological advances in controlling the drug delivery rate, it is evident that osmotic pumps have bright scope in drug development.

Keywords

Osmotic Pump, Drug Delivery, Zero-order
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  • Drug Delivery through Osmotic Micropump - a Review

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Authors

M. Sunitha Reddy
Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, India
K. Varalakshmi
Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, India
Sai Prasad
Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, India
S. Swetha
Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, India
B. Shruthi
Centre for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad, India

Abstract


This review article discusses the drug delivery systems using osmotic principles for pumping and some of the milestones in Osmotic Drug Delivery (ODDs) systems developed till date. Recent technological advances led to the development of low flow rate biocompatible micropumps. Drug delivery methods are considered as one of the salient characteristic feature to enhance efficacy of a drug. Micropumps help in achieving this by controlled drug delivery which is not possible in traditional methods (tablets and injections). Osmotic systems further increases the patient compliance, decreases dose related adverse events and most importantly helps in controlling or constant drug release (zero-order). Drug release from these systems is independent of pH and other physiological parameters to a large extent. Based on the potential advantages and persistent market demand for new technological advances in controlling the drug delivery rate, it is evident that osmotic pumps have bright scope in drug development.

Keywords


Osmotic Pump, Drug Delivery, Zero-order

References