Research Journal of Pharmacy and Technology

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Malabsorption of Drugs in Gastrointestinal Diseases: a Review


Affiliations
1 Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, India
     

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Most long term treatments follow the oral administration due to its ease and convenience of administration. After oral administration of any drug, the plasma concentration time curve is a function of many simultaneously operating kinetic processes. The steady state plasma concentration is achieved when the amount of drug absorbed equals the amount of drug eliminated. Both amount and rate of drug absorbed may be altered by diseases which in turn alter other kinetic processes. The amount of drug absorbed is simultaneously affected by physicochemical factors of drug and physiological factors that operate in gut which are also altered by the disease state. The present review focuses on the way in which the absorption of drugs is altered in various conditions of gastro intestinal tract.

Keywords

Gastric Emptying Rate, Malabsorption, Peak Plasma Concentration, Metaclopramide
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  • Malabsorption of Drugs in Gastrointestinal Diseases: a Review

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Authors

J. Lakshmi Prasanna
Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, India
B. Deepthi
Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, India
N. Rama Rao
Department of pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, India

Abstract


Most long term treatments follow the oral administration due to its ease and convenience of administration. After oral administration of any drug, the plasma concentration time curve is a function of many simultaneously operating kinetic processes. The steady state plasma concentration is achieved when the amount of drug absorbed equals the amount of drug eliminated. Both amount and rate of drug absorbed may be altered by diseases which in turn alter other kinetic processes. The amount of drug absorbed is simultaneously affected by physicochemical factors of drug and physiological factors that operate in gut which are also altered by the disease state. The present review focuses on the way in which the absorption of drugs is altered in various conditions of gastro intestinal tract.

Keywords


Gastric Emptying Rate, Malabsorption, Peak Plasma Concentration, Metaclopramide

References