Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hepatoprotective Activity of Borreria hispida on Paracetamol Induced Liver Damage


Affiliations
1 Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, India
     

   Subscribe/Renew Journal


Hepatocyte are the functional cells of the liver and perform a wide range of metabolic, secretory and endocrine functions. Hepatotoxicity implies chemical-driven liver damage. The liver plays a major role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Other chemical agents, those used in laboratories and industries, natural chemicals and herbal remedies can also cause hepatotoxicity. Borreria hispida seed flavonoid-rich fraction possesses free radical scavenging and antioxidant activity both in vitro and in vivo Borreria hispida Linn has been in use in the Indian system of medicine. Various part of the plant are useful in the treatment of antifertility, appetite, Bleeding in child birth, body ache, Gum trouble, scabies and skin disease, Stomach compliance, Ulcers, hepatitis, Wounds, head ache and tooth ache. The hepatotoxicity is induced by the paracetamol overdose, and the methanolic extract of Borreria hispida shows a good reduction of hepatotoxicity.

Keywords

Borreria hispida, Paracetamol, Hepatocyte, Hepatotoxicity
Subscription Login to verify subscription
User
Notifications
Font Size


  • Gerard J. Tortara Bryan H.Derrickson, Principles of anatomy & Physiology by 12th edition, Page 945, 1999.

  • Trotter, Wachs, Everson, Kam; Medical Progress; Adult-to-Adult Transplantation of the Right Hepatic Lobe. The New England Journal of Medicine, April 4, Vol. 346, 2002, Page 1074-1082.

  • Harsha Mohan, Essential Pathology, 3rd Edition, 2007, Page 361.

  • Bain PJ: Liver. In: Latimer KS, Mahaffey EA, Prasse KW: Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology, 4th ed. Ames, Iowa State Press, Page 193-214, 2003.

  • Gaze DC. "The role of existing and novel cardiac biomarkers for cardioprotection". Curr. Opin. Invest. Drugs 8 (9): 2007, Page 711–717.

  • Tamás L, Huttová J, Mistrk I, Kogan G, "Effect of Carboxymethyl Chitin-Glucan on the Activity of Some Hydrolytic Enzymes in Maize Plants". Chem. Pap. 56 (5): 2002, Page 326 – 329.

  • Lange PH, Millan JL, Stigbrand T, Vessella RL, Ruoslahti E, Fishman WH,"Placental alkaline phosphatase as a tumo.r marker for seminoma". Cancer Res. 42 (8): 1982, Page 3244 –7.

  • Sarich TC, Adams SP, Petricca G, Wright JM, "Inhibition of Isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor". J. Pharmacol. Exp. Ther. 289 (2): 1999, 695–702.

  • Pak E, Esrason KT, Wu VH, "Hepatotoxicity of herbal remedies: an emerging dilemma". Progress in Transplantation 14 (2): Page 91– 6, 2004.

  • Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, and Brodie BB, Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187: 1973, Page 211–217.

  • Tirmenstein MA and Nelson SD, Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a non-hepatotoxicisomer, 3-hydroxyacetanilide, in mouse liver. J Biol Chem 264: 1989, Page 9814–9819.

  • Tsokos-Kuhn JO, Hughes H, Smith CV, and Mitchell JR, Alkylation of the liver plasma membrane and inhibition of the Ca2+ATPase by acetaminophen. Biochem Pharmacol 37: 1988, Page 2125 – 2131.

  • Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, and Herman B, The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and Autophagy. Biochim Biophys Acta 1366: 1998, Page 177–196.

  • Palmeira CM and Wallace KB, Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones. Toxicol Appl Pharmacol 143: 1997, Page 338–347.

  • Hinson JA, Pike SL, Pumford NR, and Mayeux PR, Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol 11: 1998, Page 604–607.

  • Bourdi M, Masubuchi Y, Reilly TP, Amouzadeh HR, Martin JL, George JW, Shah AG, and Pohl LR, Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 35: 2002, Page 289–298.


Abstract Views: 614

PDF Views: 0




  • Hepatoprotective Activity of Borreria hispida on Paracetamol Induced Liver Damage

Abstract Views: 614  |  PDF Views: 0

Authors

D. Benito Johnson
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, India
C. Senthil Kumar
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, India
R. Rajesh
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, India
R. Venkatnarayanan
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, India
VK Mohammed Ansar
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu, India

Abstract


Hepatocyte are the functional cells of the liver and perform a wide range of metabolic, secretory and endocrine functions. Hepatotoxicity implies chemical-driven liver damage. The liver plays a major role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Other chemical agents, those used in laboratories and industries, natural chemicals and herbal remedies can also cause hepatotoxicity. Borreria hispida seed flavonoid-rich fraction possesses free radical scavenging and antioxidant activity both in vitro and in vivo Borreria hispida Linn has been in use in the Indian system of medicine. Various part of the plant are useful in the treatment of antifertility, appetite, Bleeding in child birth, body ache, Gum trouble, scabies and skin disease, Stomach compliance, Ulcers, hepatitis, Wounds, head ache and tooth ache. The hepatotoxicity is induced by the paracetamol overdose, and the methanolic extract of Borreria hispida shows a good reduction of hepatotoxicity.

Keywords


Borreria hispida, Paracetamol, Hepatocyte, Hepatotoxicity

References