Toxicology International (Formerly Indian Journal of Toxicology)

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Alterations in Antioxidant and Hematological Indices in Diabetic and Non Diabetic Rats Exposed to Paint Fumes


Affiliations
1 Department of Medical Biochemistry, Federal University, Ndufu-Alike Ikwo, Ebonyi State, Nigeria
2 Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
     

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Toxicities of various kinds due to inhalation of fumes from paint industries as well as housing estates in Nigeria and indeed in many Africa countries are now being realized as an occupational hazard. In this study, the effects of paint fumes on oxidative stress and hematological parameters in diabetic and normal rats were investigated. The rats were exposed to paint fumes for 7 days. The result of groups 4-6 (diabetic) showed significant increase (P < 0.05) in glucose levels compared to groups 1-3 (non diabetic). After exposure of groups 2, 3, 5, and 6 to paint fumes, groups 2 and 3 showed a non significant increase (P > 0.05) in their glucose when compared to group 1 while group 5-6 gave a significant elevation of blood glucose level when compared to group 4. Red blood cell in groups 4-6 (diabetic groups) were significantly (P < 0.05) reduced when compared to group 1. However, there was no significant lipid per oxidation (malondialdehyde) in groups 2, 3, 4, and 5 except in group 6 when compared to group 1 (normal control). There were non significant decreases (P > 0.05) in antioxidant levels across groups 1-6. The results of packed cell volume in group 6 (diabetic exposed to oil paint fumes) were significantly (P < 0.05) lower compared to group 1. Methemoglobin concentration showed a significant (P < 0.05) increase in groups 3 (normal rats exposed to oil paint fumes) and 6 (diabetic rats exposed to oil paint fumes) when compared to group 1. In conclusion, paint suppresses certain hematopoietic processes and complicates diabetic status in rats.

Keywords

Alloxan-Induced, Antioxidants, Diabetes Mellitus, Inhalation Chamber, Paint Fumes.
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  • Alterations in Antioxidant and Hematological Indices in Diabetic and Non Diabetic Rats Exposed to Paint Fumes

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Authors

Ogbu Patience Nkemjika
Department of Medical Biochemistry, Federal University, Ndufu-Alike Ikwo, Ebonyi State, Nigeria
N. Ogugua Victor
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
Apeh Victor Onukwube
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
Anaduaka Emeka Godwin
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria

Abstract


Toxicities of various kinds due to inhalation of fumes from paint industries as well as housing estates in Nigeria and indeed in many Africa countries are now being realized as an occupational hazard. In this study, the effects of paint fumes on oxidative stress and hematological parameters in diabetic and normal rats were investigated. The rats were exposed to paint fumes for 7 days. The result of groups 4-6 (diabetic) showed significant increase (P < 0.05) in glucose levels compared to groups 1-3 (non diabetic). After exposure of groups 2, 3, 5, and 6 to paint fumes, groups 2 and 3 showed a non significant increase (P > 0.05) in their glucose when compared to group 1 while group 5-6 gave a significant elevation of blood glucose level when compared to group 4. Red blood cell in groups 4-6 (diabetic groups) were significantly (P < 0.05) reduced when compared to group 1. However, there was no significant lipid per oxidation (malondialdehyde) in groups 2, 3, 4, and 5 except in group 6 when compared to group 1 (normal control). There were non significant decreases (P > 0.05) in antioxidant levels across groups 1-6. The results of packed cell volume in group 6 (diabetic exposed to oil paint fumes) were significantly (P < 0.05) lower compared to group 1. Methemoglobin concentration showed a significant (P < 0.05) increase in groups 3 (normal rats exposed to oil paint fumes) and 6 (diabetic rats exposed to oil paint fumes) when compared to group 1. In conclusion, paint suppresses certain hematopoietic processes and complicates diabetic status in rats.

Keywords


Alloxan-Induced, Antioxidants, Diabetes Mellitus, Inhalation Chamber, Paint Fumes.

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DOI: https://doi.org/10.22506/ti%2F2015%2Fv22%2Fi3%2F137620