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Exploring the Effect of Chronic Exposure to Radio-Frequency Electromagnetic Radiation on Neurotransmitters and Acetylcholinesterase activity in rat Brain
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Today there is an upsurge in the public and media concern about the potential health risk of radiofrequency field exposure. Interaction of radio frequency electromagnetic radiation with the brain is a precarious apprehension in our society. The current study was aimed to evaluate the possible implications on neurotransmitter and AChE activity levels on exposure to radio frequency-electromagnetic radiation (RF-EMR) in male rats at 900 MHz and 1800 MHz frequencies for 2 h per day for 3 months. Wistar rats were categorised into three groups (n=6) viz., sham exposure, exposure to 1800 MHz and exposure to 900 MHz. At the end of the study alterations in neurotransmitters level and histopathology of brain were analysed. The brain level of dopamine, nor-adrenaline, GABA and AChE enzyme activity was found to be significantly lowered. Histopathological findings of brain showed a marked congestion of the cerebral blood vessels and few of the pyramidal cells and neuroglial cells show degenerative changes with mild inflammatory infiltration. Thus, our results suggest that exposure to RF-EMR certainly causesinhibition of AChE activity, alteration in brain transmitter levels and changes in the architecture of brain parenchymal tissue.
Keywords
RF-EMR, Dopamine, Nor-Adrenaline, GABA, Acetylcholinesterase Enzyme.
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- Information paper On Effects of Electromagnetic Field Radiation from Mobile Towers and Handsets. Telecom Regulatory Authority of India. Mahanagar Doorsanchar Bhawan Jawahar Lal Nehru Marg. New Delhi, India. 2014;1:1-39
- Alberts B, Johnson A, Lewis J, Raff M, Roberts K, And Walter P, Molecular Biology of the Cell. Amino Acids. 2008;54.
- Goldsworthy A. The Biological Effects of Weak Electromagnetic Fields Problems and solutions. MCS Am. News. 2012;7:1–27.
- Finnie JW, Cai Z, Manavis J, Helps S, Blumbergs PC. Microglial activation as a measure of stress in mouse brains exposed acutely (60 minutes) and long-term (2 years) to mobile telephone radiofrequency fields. Pathology. 2010;42:151–154.
- Masuda H, Ushiyama A, Takahashi M, Wang J, Fujiwara O, Hikage T, Nojima T, Fujita K, Kudo M, Ohkubo C. Effects of 915 MHz electromagnetic-field radiation in TEM cell on the blood-brain barrier and neurons in the rat brain. Radiat. Res. 2009;172:66–73.
- Salford LG, Brun AE, Eberhardt JL, Malmgren L, Persson BRR. Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ. Health Perspect. 2003; 111:881–883.
- Tarantino P, Lanubile R, Lacalandra G, Abbro L, Dini L. Post-continuous whole body exposure of rabbits to 650 MHz electromagnetic fields: Effects on liver, spleen, and brain, Radiat. Environ. Biophys. 2005;44: 51–59.
- Mausset-Bonnefont AL, Hirbec H, Bonnefont X, Privat A, Vignon J, De Sèze R. Acute exposure to GSM 900MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain.Neurobiol. Dis.2004;17:445–454.
- Schlumpf M, Lichtensteiger W, Langemann H, Waser PG, Hefti F. A fluorometric micromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amounts of brain tissue.Biochem. Pharmacol. 1974;23: 2437–2446.
- Atack C V. The determination of dopamine by a modification of the dihydroxyindole fluorimetric assay. Br. J. Pharmacol. 1973;48:699–714.
- A. Saravana kumar and r. Gandhimathi, Effect of guettarda speciosa extracts on biogenic amines concentrations in rat brain after induction of seizure. Int. J. Pharm. Pharm. Sci. 2009;1:237–243.
- Lai H, Horita A, Guy AW. Microwave irradiation affects radialarm maze performance in the rat. Bioelectromagnetic. 1994;15:95–104.
- Narayanan SN, Kumar RS, Potu BK, Nayak S, Bhat PG, Mailankot M. Effect of radio-frequency electromagnetic radiations (RF-EMR) on passive avoidance behaviour and hippocampal morphology in Wistar rats. Ups. J. Med. Sci. 2010;115; 91–96.
- Zola-Morgan SM, Squire LR. The primate hippocampal formation: evidence for a time-limited role in memory storage. Science. 1990;250:288–290
- Stubley-Weatherly L, Harding JW, Wright JW. Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats.Brain Res.1996;716:29–38.
- Salford LG, Brun AE, Eberhardt JL, Malmgren L, Persson BRR. Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ. Health Perspect.. 2003;111:881–883.
- Taylor MVaidya N. Descriptive psychopathology. Cambridge, UK: Cambridge University Press; 2009.
- Dutta SK, Das K, Ghosh B, Blackman CF. Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation. Bioelectromagnetics.1992;13:317–322.
- Kunjilwar KK, Behari J. Effect of amplitude-modulated radio frequency radiation on cholinergic system of developing rats. Brain Res.1993;601:321–324.
- Laila K. Hanafy, Sawsan H, Karam A, The adverse effects of mobile phone radiation on some visceral organs. Res. J. Med. Med. Sci. 2010;5:95–99.
- Boris Đ, Sokolovi D, Krsti D, Petkovi D, Jovanovi J, Muratovi M. Biochemical and histopathological effects of mobile phone exposure on rat hepatocytes and brain. ActaMedica Median. 2010;49:37–42.
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