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A Rare Case of Acute Cyanide Poisoning from Cyanmethemoglobin Reagent Ingestion


Affiliations
1 Dept. of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Dhanvantrinagar, Puducherry, Pondicherry, India
     

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Acute poisoning from cyanides frequently gives rise to lethal toxicity and rapid death. Although many cases of acute cyanide poisoning resulting from inhalation of hydrogen cyanide and ingestion of inorganic cyanide salts have been reported, acute poisoning resulting from ingestion of cyanmethemoglobin reagent (also called Drabkin's reagent, contains potassium cyanide) has most probably not been reported so far. Here we report a rare case of acute cyanide poisoning in a 30-year-old female laboratory technician resulting from deliberate ingestion of commercially available, ready to use liquid cyanmethemoglobin reagent used for colorimetric determination of hemoglobin in blood. She made an uneventful recovery with treatment.

Keywords

Acute Poisoning, Cyanides, Drabkin’s Reagent, Cytochrome Oxidase.
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  • Concise International Chemical Assessment Document 61. Hydrogen cyanide and cyanides: human health aspects. World Health Organization 2004;pp:4-6
  • Medical management guidelines for hydrogen cyanide (HCN). Agency for toxic substances and disease registry (ATDSR), Centers for Disease Control and Prevention (CDC) toxic substances portal.(Accessed from https:// www.atsdr.cdc.gov/MMG/MMG.asp? d=1141 tid=249# on 5th May 2016)
  • Robert JG, Claudia B, Jane AS, Alan HH. Pediatric cyanide poisoning: causes, manifestations, management, and unmet needs. Pediatrics 2006; 118: 2146-58
  • Jillian H. A review of acute cyanide poisoning with a treatment update. Crit Care Nurse 2011; 31: 72-80
  • Dikshit N, Tiwari M, Dewan A. A case of sodium cyanide poisoning in a young male. Natl J Med Res 2014;4:106-108
  • Pradhan M, Pawar A, Chand S, Behera C, Dikshit PC. Accidental cyanide poisoning from inhalation of gold polishing chemical: an unusual case report.J Punjab Acad Forensic Med Toxicol 2012;12:104-6
  • Barillo DJ. Diagnosis and treatment of cyanide toxicity. J Burn Care Res 2009;30:148–52
  • Borron SW, Baud FJ, Mégarbane B, Bismuth C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med 2007;25:551–558
  • Baud FJ, Borron SW, Mégarbane B, Trout H, Lapostolle F, Vicaut E, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning.Crit Care Med 2002;30:2044-50

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  • A Rare Case of Acute Cyanide Poisoning from Cyanmethemoglobin Reagent Ingestion

Abstract Views: 681  |  PDF Views: 1

Authors

Kolar Vishwanath Vinod
Dept. of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Dhanvantrinagar, Puducherry, Pondicherry, India
Kalyappan Anupriya
Dept. of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Dhanvantrinagar, Puducherry, Pondicherry, India
M. Vivekanandan
Dept. of General Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research [JIPMER], Dhanvantrinagar, Puducherry, Pondicherry, India

Abstract


Acute poisoning from cyanides frequently gives rise to lethal toxicity and rapid death. Although many cases of acute cyanide poisoning resulting from inhalation of hydrogen cyanide and ingestion of inorganic cyanide salts have been reported, acute poisoning resulting from ingestion of cyanmethemoglobin reagent (also called Drabkin's reagent, contains potassium cyanide) has most probably not been reported so far. Here we report a rare case of acute cyanide poisoning in a 30-year-old female laboratory technician resulting from deliberate ingestion of commercially available, ready to use liquid cyanmethemoglobin reagent used for colorimetric determination of hemoglobin in blood. She made an uneventful recovery with treatment.

Keywords


Acute Poisoning, Cyanides, Drabkin’s Reagent, Cytochrome Oxidase.

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DOI: https://doi.org/10.22506/ti%2F2016%2Fv23%2Fi3%2F146729