Toxicology International (Formerly Indian Journal of Toxicology)

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Immune Response to Sub Acute Toxicity of Thiacloprid Insecticide in Gallus domesticus


Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, India
     

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Thiacloprid is fairly a new chemical, but it has established itself as key component in insecticides because of its selectivity and low toxicity. It is effective on contact and via stomach action and bind agonistically to the nicotinic acetylcholine receptors in the CNS of insects, affecting synaptic transmission and leading to disruption of the nervous system. The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. It can be the target of many chemicals, with potentially severe adverse effects on the host’s health. The health implications of these immune dysfunctions are increased risk of infectious diseases; development of neoplasia; autoimmune disorders and allergies. Estimation of total immunoglobulins and enumeration of B and T lymphocytes in blood after repeated oral administration of thiacloprid at the dose rate of 10 mg/kg/day revealed no significant alterations in Gallus domesticus. The observed findings in the present study indicated that repeated thiacloprid exposure in poultry birds did not adversely affect the immune status of Gallus domesticus and thus is immunologically safer insecticide.

Keywords

Toxicity, Gallus domesticus, Thiacloprid, Insecticide, Immune System.
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  • Immune Response to Sub Acute Toxicity of Thiacloprid Insecticide in Gallus domesticus

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Authors

Saloni Singla
Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, India
V. K. Dumka
Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, India

Abstract


Thiacloprid is fairly a new chemical, but it has established itself as key component in insecticides because of its selectivity and low toxicity. It is effective on contact and via stomach action and bind agonistically to the nicotinic acetylcholine receptors in the CNS of insects, affecting synaptic transmission and leading to disruption of the nervous system. The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. It can be the target of many chemicals, with potentially severe adverse effects on the host’s health. The health implications of these immune dysfunctions are increased risk of infectious diseases; development of neoplasia; autoimmune disorders and allergies. Estimation of total immunoglobulins and enumeration of B and T lymphocytes in blood after repeated oral administration of thiacloprid at the dose rate of 10 mg/kg/day revealed no significant alterations in Gallus domesticus. The observed findings in the present study indicated that repeated thiacloprid exposure in poultry birds did not adversely affect the immune status of Gallus domesticus and thus is immunologically safer insecticide.

Keywords


Toxicity, Gallus domesticus, Thiacloprid, Insecticide, Immune System.

References





DOI: https://doi.org/10.22506/ti%2F2017%2Fv24%2Fi3%2F166503