Impact of di-n-butyl phthalate on haematology and biochemistry of albino rat

Di-n-butyl phthalate is a low volatile chemical added to plastic, paint, glue, hair spray, toys and house hold products. Human being and animal are exposed to di-n-butyl phthalate through air, water and food contamination in the environment. For present study, a group of six infection free rats were acclimatized under laboratory condition and divided in to two groups three in each. Group I (control) albino rat fed commercial feed with corn oil. Group II albino rats were given 50mg/kg/day di-n-butyl phthalate with corn oil for 2 week. The study revealed that haemaglobin gm%, RBC and lymphocytes were decreased, 14.6% to 7.8%, 6.17-4.19 millions/cmm and 78 to 44% respectively. However, number of neutrophils were increased .A significant decrease in cholesterol level (121- 51 mg/dl), protein (10 to 4.6 gm/dl) and glucose was observed in di-n-butyl phthalate exposed rats.