Toxicology International (Formerly Indian Journal of Toxicology)

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Ecotoxicological Studies of Cephalosporin Antibiotics on Daphnia Magna


Affiliations
1 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, India
     

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The present research was outlined to survey the intense and incessant poisonous quality of Cefixime and Cefotaxime antibiotics on Daphnia magna. The toxicity of Cefixime and Cefotaxime antibiotics was evaluated by 48h acute toxicity (US, EPA, 2002) and chronic toxicity (OECD guidelines 211 (OECD, 2012)). The data showed that EC50 of Cefixime was 78.78 mg/l and for Cefotaxime was 25.82 mg/l. Daphnia magna. showed more sensitivity to Cefotaxime, when compared with Cefixime antibiotic. Chronic toxicity showed that, Cefotaxime cause effects on reproduction but Cefixime had no adverse effect on Daphnia. The mortality rate enhanced and average number of neonates diminished as exposure to Cefotaxime antibiotic was increased. Daphnia. died (50%) at a concentration of 16.2 mg/l of Cefotaxime.

Keywords

Cephalosporin, Non Target Organisms, Reproduction, Toxicity, Daphnia Magna.
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  • Arome D, Chinedu E. The importance of toxicity testing, Journal of Pharmaceutical and Bio. Sciences. 2013; 4:146–8.

  • Awad YM, Kim SC, El-Azeem SA, Kim KH, Kim KR, Kim K, Jeon C, Lee SS, Ok YS. Veterinary antibiotics contamination in water, sediment, and soil near a swine manure composting facility, Environmental Earth Sci. 2014; 71(3):1433–40. https://doi.org/10.1007/s12665-0132548-z.

  • Andrieu M, Rico A, Phu TM, Phuong NT, Van den Brink PJ. Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta, Vietnam, Chemosphere. 2015; 119:407–14. https://doi.org/10.1016/j.chemosphere.2014.06.062. PMid: 25063964.

  • Azhar MR, Abid HR, Sun H, Periasamy V, Tadé MO, Wang S. Excellent performance of copper based metal organic framework in adsorptive removal of toxic sulfonamide antibiotics from waste water, Journal of Colloid and Interface Science. 2016; 478: 344–52. https://doi.org/10.1016/j.jcis.2016.06.032. PMid: 27318714.

  • Baguer AJ, Jensen J, Krogh PH. Effects of the antibiotics oxytetracycline and tylosin on soil fauna, Chemosphere. 2000; (7):751–57. https://doi.org/10.1016/S00456535(99)00449-X.

  • Bernot RJ, Brueseke MA, Evans‐White MA, Lamberti GA. Acute and chronic toxicity of imidazolium‐based ionic liquids on Daphnia magna, Environmental Toxicology and Chemistry. 2005; 24(1):87–92. https://doi.org/10.1897/03635.1. PMid: 15683171.

  • Bao X, Qiang Z, Chang JH, Ben W, Qu J. Synthesis of carbon-coated magnetic nanocomposite (Fe3O4@ C) and its application for sulfonamide antibiotics removal from water, J. Environ. Sci. 2014; 26(5):962–69. https://doi.org/10.1016/S1001-0742(13)60485-4.

  • Becker D, Della Giustina SV, Rodriguez-Mozaz S, Schoevaart R, Barceló D, de Cazes M, Belleville MP, SanchezMarcano J, de Gunzburg J, Couillerot O, Völker J. Removal of antibiotics in wastewater by enzymatic treatment with fungal laccase-degradation of compounds does not always eliminate toxicity, Bioresource Technology. 2016; 219:500– 9. https://doi.org/10.1016/j.biortech.2016.08.004. PMid: 27521787.

  • Bundschuh M, Hahn T, Ehrlich B, Höltge S, Kreuzig R, Schulz R. Acute toxicity and environmental risks of five veterinary pharmaceuticals for aquatic macro invertebrates, Bulletin of Environmental Contamination and Toxicology. 2016; 96(2):139–43. https://doi.org/10.1007/s00128-0151656-8. PMid: 26408031.

  • Çavaş T, Ergene-Gözükara S. Genotoxicity evaluation of metronidazole using the piscine micronucleus test by acridine orange fluorescent staining, Environmental Toxicology and Pharmacology. 2005; 19(1):107–11. https:// doi.org/10.1016/j.etap.2004.05.007. PMid: 21783466.

  • Chen J, Qiu X, Fang Z, Yang M, Pokeung T, Gu F, Cheng W, Lan B. Removal mechanism of antibiotic metronidazole from aquatic solutions by using nanoscale zero-valent iron particles, Chemical Engineering Journal. 2012; 181:113–19. https://doi.org/10.1016/j.cej.2011.11.037.

  • Cho H, Uehara T, Bernhardt TG. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery, Cell. 2014; 159(6):1300–11. https://doi.org/10.1016/j.cell.2014.11.017. PMid: 25480295, PMCid: PMC4258230.

  • Du W, Zhou H, Luo Z, Zheng P, Guo P, Chang R, Chang C, Fu Q. Selective determination of penicillin G from tap water and milk samples using surface molecularly imprinted polymers as solid-phase extraction sorbent, Molecular Imprinting. 2014; 2(1):18–29. https://doi.org/10.2478/molim-2014-0002.

  • Etebu E, Arikekpar I. Antibiotics: Classification and mechanisms of action with emphasis on molecular perspectives, Int. J. Appl. Microbiol. Biotechnol. 2016; 4:90–101.

  • Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DJ. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments, Environmental Science and Technology. 2008; 42(15):5807–13. https://doi.org/10.1021/es8005173. PMid:18754513.

  • Guerra P, Kim M, Shah A, Alaee M, Smyth S A. Occurrence and fate of antibiotic, analgesic/anti-inflammatory, and antifungal compounds in five wastewater treatment processes, Science of the Total Environment. 2014; 473:235– 43. https://doi.org/10.1016/j.scitotenv.2013.12.008. PMid: 24370698.

  • Heckmann LH, Callaghan A, Hooper HL, Connon R, Hutchinson TH, Maund SJ, Sibly RM. Chronic toxicity of ibuprofen to Daphnia magna: Effects on life history traits and population dynamics, Toxicology Letters. 2007; 172(3):137–45. https://doi.org/10.1016/j.toxlet.2007.06.001. PMid: 17658227.

  • Harris KD, Bartlett NJ, Lloyd VK. Daphnia as an emerging epigenetic model organism, Genetics Research International. 2012; 8. https://doi.org/10.1155/2012/147892. PMid: 22567376, PMCid: PMC3335723.

  • Huang CH, Renew JE, Smeby KL, Pinkston K, Sedlak DL. Assessment of potential antibiotic contaminants in water and preliminary occurrence analysis, Journal of Contemporary Water Research and Education. 2011; 120(1):4.

  • He K, Soares AD, Adejumo H, McDiarmid M, Squibb K, Blaney L. Detection of a wide variety of human and veterinary fluoroquinolone antibiotics in municipal wastewater and wastewater-impacted surface water, Journal of Pharmaceutical and Biomedical Analysis. 2015; 106:136–43. https://doi.org/10.1016/j.jpba.2014.11.020. PMid: 25483174.

  • Humayun A, Siddiqui FM, Akram N, Saleem S, Ali A, Iqbal T, Kumar A, Kamran R, Bokhari H. Incidence of metallo-beta-lactamase-producing Klebsiella pneumoniae isolates from hospital setting in Pakistan, International Microbiology. 2018; 21(1-2):73–78. https://doi.org/10.1007/s10123-018-0006-1. PMid: 30810920.

  • Isidori M, Lavorgna M, Nardelli A, Pascarella L, Parrella A. Toxic and genotoxic evaluation of six antibiotics on non-target organisms, Science of the Total Environment. 2005; 346(1-3):87–98. https://doi.org/10.1016/j.scitotenv.2004.11.017. PMid: 15993685.

  • Ibraimi Z A, Shehi A, Hajrulai Z, Mata E, Murtezani A, Detection and risk assessment of beta-lactam residues in kosovos milk using elisa method, Int. J. Pharm. Sci. 2013; 5(4): 446–50.

  • Jiang H, Zhang D, Xiao S, Geng C, Zhang X. Occurrence and sources of antibiotics and their metabolites in river water, WWTPs, and swine wastewater in Jiulongjiang River basin, south China, Environmental Science and Pollution Research. 2013; 20(12):9075–83. https://doi.org/10.1007/s11356-013-1924-2. PMid: 23812735.

  • Kim B, Ji K, Kho Y, Kim PG, Park K, Kim K, Kim Y, Kim KT, Choi K. Effects of chronic exposure to cefadroxil and cefradine on Daphnia magna and Oryzias latipes, Chemosphere. 2017; 185:844–51. https://doi.org/10.1016/j.chemosphere.2017.07.085. PMid: 28735237.

  • Luo Y, Xu L, Rysz M, Wang Y, Zhang H, Alvarez P J. Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China, Environmental Science and Technology. 2011; 45(5):1827–33. https://doi.org/10.1021/es104009s. PMid: 21309601.

  • Liu C, Nanaboina V, Korshin G. Spectroscopic study of the degradation of antibiotics and the generation of representative EfOM oxidation products in ozonated waste water, Chemosphere. 2012; 86(8):774–82. https://doi.org/10.1016/j.chemosphere.2011.11.003. PMid: 22153484.

  • Liang X, Chen B, Nie X, Shi Z, Huang X, Li X. The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China, Chemosphere. 2013; 92(11):1410–16. https://doi.org/10.1016/j.chemosphere.2013.03.044. PMid: 23628172.

  • Li L, Wei D, Wei G, Du Y. Transformation of cefazolin during chlorination process: Products, mechanism and genotoxicity assessment, Journal of Hazardous Materials. 2013; 262:48–54. https://doi.org/10.1016/j.jhazmat.2013.08.029. PMid: 24007998.

  • Lee J, Park N, Kho Y, Lee K, Ji K. Phototoxicity and chronic toxicity of methyl paraben and 1, 2-hexanediol in Daphnia magna, Ecotoxicology. 2017; 26(1):81–89. https://doi.org/10.1007/s10646-016-1743-6. PMid: 27866342.

  • Lv X, Yang Y, Tao Y, Jiang Y, Chen B, Zhu X, Cai Z, Li B. A mechanism study on toxicity of graphene oxide to Daphnia magna: Direct link between bioaccumulation and oxidative stress, Environmental Pollution. 2018; 234:953–59. https:// doi.org/10.1016/j.envpol.2017.12.034. PMid: 29665635.

  • Ma Y, Li M, Wu M, Li Z, Liu X. Occurrences and regional distributions of 20 antibiotics in water bodies during groundwater recharge, Science of the Total Environment. 2015; 518:498–506. https://doi.org/10.1016/j.scitotenv.2015.02.100. PMid: 25777955.

  • Nazari G, Abolghasemi H, Esmaieli M. Batch adsorption of cephalexin antibiotic from aqueous solution by walnut shell-based activated carbon, Journal of the Taiwan Institute of Chemical Engineers. 2016; 58:357–65. https:// doi.org/10.1016/j.jtice.2015.06.006.

  • Organisation for Economic Co-operation and Development. Test No. 211: Daphnia magna Reproduction Test. OECD Publishing; 2012.

  • Ribeiro AR, Sures B, Schmidt TC. Cephalosporin antibiotics in the aquatic environment: A critical review of occurrence, fate, ecotoxicity and removal technologies, Environmental Pollution. 2018; 241:1153–66. https://doi.org/10.1016/j.envpol.2018.06.040. PMid: 30029325.

  • Stollewerk A. The water flea Daphnia-a'new'model system for ecology and evolution? Journal of Biology. 2010; 9(2):21. https://doi.org/10.1186/jbiol212. PMid:20478012, PMCid: PMC2871515.

  • Siciliano A, Gesuele R, Pagano G, Guida M. How Daphnia (Cladocera) Assays may be used as Bioindicators of Health Effects? Journal of Biodiversity and Endangered Species. 2015; 1:1. https://doi.org/10.4172/2167-1206.S1-005.

  • Smith PW, Zuccotto F, Bates RW, Santos M, Martínez M, Read KD, Peet C and Epemolu O. Perspective: Pharmacokinetics of Beta lactam antibiotics: Clues from the past to help discover long acting oral drugs in the future, ACS Infect. Dis. 2018. https://doi.org/10.1021/acsinfecdis.8b00160. PMid: 30141902, PMCid: PMC6189874.

  • U.S. Environmental Protection Agency. Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms, Fifth Edition, 2002.

  • Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, Laxminarayan R. Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data, The Lancet Infectious Diseases. 2014; 14(8):742–50. https://doi.org/10.1016/S1473-3099(14)70780-7.

  • Wang XH, Lin AY. Phototransformation of cephalosporin antibiotics in an aqueous environment results in higher toxicity, Environmental Science and Technology. 2012; 46(22):12417–26. https://doi.org/10.1021/es301929e. PMid: 23062112.

  • Yang J, Qiu K. Preparation of activated carbons from walnut shells via vacuum chemical activation and their application for methylene blue removal, Chemical Engineering Journal. 2010; 165(1):209–17. https://doi.org/10.1016/j.cej.2010.09.019.

  • Yan C, Yang Y, Zhou J, Liu M, Nie M, Shi H, Gu L. Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment, Environmental Pollution. 2013; 175:22–9. https://doi.org/10.1016/j.envpol.2012.12.008. PMid: 23313734.

  • Zhang J, Meng J, Li Y, Hu C. Investigation of the toxic functional group of cephalosporins by zebrafish embryo toxicity test, Archiv. Der. Pharmazie. 2010; 343(10):553–60. https://doi.org/10.1002/ardp.201000005. PMid: 20938949.

  • Zuccato E, Castiglioni S, Bagnati R, Melis M, Fanelli R. Source, occurrence and fate of antibiotics in the Italian aquatic environment, Journal of Hazardous Materials. 2010; 179(1-3):1042–48. https://doi.org/10.1016/j.jhazmat.2010.03.110. PMid: 20456861.

  • Zhang R, Tang J, Li J, Zheng Q, Liu D, Chen Y, Zou Y, Chen X, Luo C, Zhang G. Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: Occurrence, distribution and ecological risks, Environmental Pollution. 2013; 174:71–77. https://doi.org/10.1016/j.envpol.2012.11.008. PMid: 23246749.

  • Zheng H, Wang Z, Zhao J, Herbert S, Xing B. Sorption of antibiotic sulfamethoxazole varies with biochars produced at different temperatures, Environmental Pollution. 2013; 181:60–67. https://doi.org/10.1016/j.envpol.2013.05.056. PMid: 23811180.

  • Zhou LJ, Ying GG, Liu S, Zhang RQ, Lai HJ, Chen ZF, Pan CG. Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China, Science of the Total Environment. 2013; 444:183– 95. https://doi.org/10.1016/j.scitotenv.2012.11.087. PMid: 23268145.

  • Zhao JL, Liu YS, Liu WR, Jiang YX, Su HC, Zhang QQ, Chen XW, Yang YY, Chen J, Liu SS, Pan CG. Tissue-specific bioaccumulation of human and veterinary antibiotics in bile, plasma, liver and muscle tissues of wild fish from a highly urbanized region, Environmental Pollution. 2015; 198:15–24. https://doi.org/10.1016/j.envpol.2014.12.026. PMid: 25549863.

  • Zhang Y, Zhuang Y, Geng J, Ren H, Xu K, Ding L. Reduction of antibiotic resistance genes in municipal waste water effluent by advanced oxidation processes, Science of the Total Environment. 2016; 550:184–91. https://doi.org/10.1016/j.scitotenv.2016.01.078 https://doi.org/10.1016/j.scitotenv.2016.02.106.


Abstract Views: 355

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  • Ecotoxicological Studies of Cephalosporin Antibiotics on Daphnia Magna

Abstract Views: 355  |  PDF Views: 2

Authors

Aijaz Ahmad
Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, India
Joydeep Dutta
Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, India

Abstract


The present research was outlined to survey the intense and incessant poisonous quality of Cefixime and Cefotaxime antibiotics on Daphnia magna. The toxicity of Cefixime and Cefotaxime antibiotics was evaluated by 48h acute toxicity (US, EPA, 2002) and chronic toxicity (OECD guidelines 211 (OECD, 2012)). The data showed that EC50 of Cefixime was 78.78 mg/l and for Cefotaxime was 25.82 mg/l. Daphnia magna. showed more sensitivity to Cefotaxime, when compared with Cefixime antibiotic. Chronic toxicity showed that, Cefotaxime cause effects on reproduction but Cefixime had no adverse effect on Daphnia. The mortality rate enhanced and average number of neonates diminished as exposure to Cefotaxime antibiotic was increased. Daphnia. died (50%) at a concentration of 16.2 mg/l of Cefotaxime.

Keywords


Cephalosporin, Non Target Organisms, Reproduction, Toxicity, Daphnia Magna.

References





DOI: https://doi.org/10.18311/ti%2F2018%2Fv25i3%2F22981