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Potential Protective Effects of Selenium and Zinc against Thyroid Toxicity Induced by Nickel in Preimplanted Wistar Albino Rats


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1 Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules, Department of Biology of Organismes, BATNA-2 University, 5000 Batna, Algeria
     

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Nickel Is A Heavy Metal That May Affect The Function Of The Thyroid. The Present Study Was Undertaken To Assess The Protective Effects Of Selenium And Zinc Against Nickel-induced Thyrotoxicity In Preimplanted Wistar Albino Rats. Nickel Is Administered Alone (100 Mg/kg Body Weight) Subcutaneously Or In Combination With Selenium (0.3 Mg/kg Body Weight) Either With Zinc (20 Mg/kg Body Weight) Or Combined With Both Selenium And Zinc. All Groups Of Rats Were Injected On Day 3 Of Gestation In The Pre-implantation Period. Exposure Of Rats To Nickel Caused A Significant Decrease In Maternal Body Weight On Days 6 And 20 Of Gestation And An Increase In Absolute And Relative Thyroid Weight Compared To The Controls. Nickel Treatment Was Also Led In Decreased Plasma Triiodothyronine, Thyroxine With A Concomitant Significant Increase In Thyroid-stimulating Hormone Levels When Compared To Control. These Changes Were Confirmed By Histological Damages. However, Co-administration Of Selenium And/or Zinc To Nickel-treated Rats Restored The Hormonal And Histological Aspects. Our Findings Suggested That Selenium And Zinc Ameliorated Nickel Induced Thyroid Damage.


Keywords

Nickel, Preimplanted Rat, Thyroid Hormones, Selenium, Zinc.
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  • Zambelli B, Uversky VN, Ciurli S. Nickel impact on human health: An intrinsic disorder perspective. Biochimica et Biophysica Acta. 2016; 1864(12): 1714–31.https://doi .org/10.1016/j.bbapap.2016.09.008. PMid:27645710

  • Zeinali T, Salmani F, Naseri K. Dietary intake of Cadmium, Chromium, Copper, Nickel, and Lead through the consumption of meat, liver, and kidney and assessment of human health risk in Birjand, Southeast of Iran. Biological Trace Element Research. 2019; 191(2):338–47. https://doi .org/10.1007/s12011-019-1637-6. PMid:30729389

  • Minigaliyeva IA, Katsnelson BA, Privalova LI, Gurvich VB, Panov VG, Varaksin AN, et al. Toxicodynamic and toxicokinetic descriptors of combined chromium (VI) and nickel toxicity. International Journal of Toxicology. 2014; 33(6):498–505.https://doi.org/10.1177/1091581814555915. PMid:25355735

  • Xu S, He M, Zhong M, Li L, Lu Y, Zhang Y, et al. The neuroprotective effects of taurine against nickel by reducing oxidative stress and maintaining mitochondrial function in cortical neurons. Neuroscience Letters. 2015; 590: 52–7. https://doi.org/10.1016/j.neulet.2015.01.065 . PMid:25637701

  • Goodman JE, Prueitt RL, Dodge DG, Thakali S. Carcinogenicity assessment of water-soluble nickel compounds. Critical Reviews in Toxicology. 2009; 39(5): 365–417.https://doi.org/10.1080/10408440902762777. PMid:19514913

  • Adjroud O, Mouffok S. Effects of nickel chloride on hematological and developmental parameters in Wistar albino pregnant rats. Assiut University Bulletin For Environmental Researches. 2009; 12(1):1–9.

  • International Agency for Research on Cancer. Chromium, nickel and welding. IARC Monogr Eval Carcinog Risks Hum. 1990; 49:1–648.

  • Cameron KS, Buchner V, Tchounwou PB. Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: A literature review. Reviews on Environmental Health. 2011; 26(2):81–92. https:// doi.org/10.1515/reveh.2011.012. PMid:21905451. PMCid:PMC3172618

  • Gartner LP, Hiatt JL. Color textbook of histology 3rd ed. Saunders Elsevier; 2007.

  • Cheng W, Zhou Z, Yang Y, Yin C, Chai GW. Effect of nickel sulfate on the concentrations of T3, T4 and TSH in serum of rat. Wei sheng yan jiu = Journal of hygiene research. 1997; 26(1):53–55, 59.

  • Al-Mogairen S. Induction of an autoimmune thyroid disease with nickel chloride in brown norway rats. Turkish Journal of Endocrinology and Metabolism. 2009; 13:71–4.

  • Ali WDA, Khudair ZW, Abed MJ. Histopathological changes in male rabbits thyroid gland following drenching of nickel chloride and the ameliorating effect of ethanolic silyybum marianum seeds extract. International Journal of Research in Humanities, Arts and Literature. 2016; 4:11–16.

  • Pelyhe C, Mézes M. Myths and facts about the effects of nano selenium in farm animals-mini-review. European Chemical Bulletin. 2013; 2(12):1049–52.

  • Zoidis E, Seremelis I, Kontopoulos N, Danezis GP. Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins. Antioxid. 2018; 7(5):66. https://doi.org/10.3390/antiox7050066. PMid:29758013 PMCid:PMC5981252

  • Fargašová A, Pastierová J, Svetková K. Effect of Se-metal pair combinations (Cd, Zn, Cu, Pb) on photosynthetic pigments production and metal accumulation in Sinapis alba L. seedlings. Plant, Soil and Environment. 2006; 52(1):8. https://doi.org/10.17221/3340-PSE

  • Chen X, Zhu Y-H, Cheng X-Y, Zhang Z-W, Xu S-W. The protection of selenium against cadmium-induced cytotoxicity via the heat shock protein pathway in chicken splenic lymphocytes. Molecules. 2012; 17(12):14565–72. https:// doi.org/10.3390/molecules171214565. PMid:23222903 PMCid:PMC6268861

  • Käkelä R, Käkelä A, Hyvärinen H. Effects of nickel chloride on reproduction of the rat and possible antagonistic role of selenium. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 1999; 123(1):27–37. https://doi.org/10.1016/S07428413(99)00006-7

  • Adjroud O. The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment. Environmental Toxicology. 2013; 28(5):290–8. https://doi .org/10.1002/tox.20719. PMid:21618677

  • Formigari A, Irato P, Santon A. Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: Biochemical and cytochemical aspects. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 2007; 146(4):443–59. https://doi .org/10.1016/j.cbpc.2007.07.010. PMid:17716951

  • Catania AS, Barros CR, Ferreira SRG. Vitamins and minerals with antioxidant properties and cardiometabolic risk: controversies and perspectives. Arquivos Brasileiros de Endocrinologia & Metabologia. 2009; 53(5):550–9. https://doi.org/10.1590/S0004-27302009000500008. PMid:19768246

  • Kasprzak KS, Waalkes MP, Poirier LA. Antagonism by essential divalent metals and amino acids of nickel (II)-DNA binding in vitro. Toxicology and Applied Pharmacology. 1986; 82(2):336–43. https://doi.org/10.1016/0041-008X(86)90210-3

  • Djemli S, Kechrid Z, Djabar MR. Combined protective effect of zinc and vitamin C on nickel-induced oxidative liver injury in rats. Annals of Biological Research. 2012; 3(7):3410–18.

  • Adjroud O. Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [d-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro. Reprod. 1995; 104(2):181–6. https://doi.org/10.1530/jrf.0.1040181. PMid:7473405

  • Adjroud O. Protective effects of selenium against potassium dichromate induced hematotoxicity in female and male Wistar albino rats. Ann Toxicol Anal. 2010; 22(4):165–72. https://doi.org/10.1051/ata/2010025

  • Costa M, Davidson TL, Chen H, Ke Q, Zhang P, Yan Y, Huang C, Kluz T. Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005; 592(1– 2):79–88. https://doi.org/10.1016/j.mrfmmm.2005.06.008. PMid:16009382

  • Cempel M, Nikel G. Nickel: A review of its sources and environmental toxicology. Polish Journal of Environmental Studies. 2006; 15(3):375–82.

  • Vijayavel K, Gopalakrishnan S, Thiagarajan R, Thilagam H. Immunotoxic effects of nickel in the mud crab Scylla serrata. Fish and Shellfish Immunology. 2009; 26(1):133–9. https://doi.org/10.1016/j.fsi.2008.02.015. PMid:19046900

  • Kubrak OI, Husak VV, Rovenko BM, Poigner H, Kriews M, Abele D, et al. Antioxidant system efficiently protects goldfish gills from Ni2+-induced oxidative stress. Chemosphere. 2013; 90(3):971–6. https://doi.org/10.1016/j.chemosphere.2012.06.044. PMid:22832340

  • Adeyemi OS, Orekoya BT. Lipid profile and oxidative stress markers in Wistar rats following oral and repeated exposure to fijk herbal mixture. Journal of Toxicology. 2014; 2014:876035. https://doi.org/10.1155/2014/876035. PMid:25386188 PMCid:PMC4217246

  • Faoziyat SA, Amina AE-IM, Adeyemo AA, Muhammed RB, Sulaiman AM, Aliyu AO, et al. Aspergillus-fermented Jatropha curcas seed cake: Proximate composition and effects on biochemical indices in Wistar rats. Biology Letters. 2014; 51(1):37–46. https://doi.org/10.1515/biolet-2015-0004

  • Saini S, Nair N, Saini MR. Embryotoxic and teratogenic effects of nickel in Swiss albino mice during organogenetic period. BioMed Research International. 2013; 2013. https://doi.org/10.1155/2013/701439. PMid:23936836 PMCid:PMC3726022

  • Cempel M, Janicka K. Distribution of nickel, zinc, and copper in rat organs after oral administration of nickel (II) chloride. Biological Trace Element Research. 2002; 90(1–3):215. https://doi.org/10.1385/BTER:90:1-3:215

  • Amara IB, Soudani N, Troudi A, Bouaziz H, Boudawara T, Zeghal N. Antioxidant effect of vitamin E and selenium on hepatotoxicity induced by dimethoate in female adult rats. Ecotoxicology and Environmental Safety. 2011; 74(4):811–19. https://doi.org/10.1016/j.ecoenv.2010.11.007. PMid:21163531

  • Rao MV, Chawla SL, Sharma SR. Protective role of vitamin E on nickel and/or chromium induced oxidative stress in the mouse ovary. Food and Chemical Toxicology. 2009; 47(6):1368–71. https://doi.org/10.1016/j.fct.2009.03.018. PMid:19306907

  • Schreiber V, Rohacova J, Pribyl T. Endocrine changes after chronic lithium carbonate administration in rats. Physiologia Bohemoslovaca. 1971; 20:249–54.

  • Hammouda F, Messaoudi I, El Hani J, Baati T, Said K, Kerkeni A. Reversal of cadmium-induced thyroid dysfunction by selenium, zinc, or their combination in rat. Biological Trace Element Research. 2008; 126(1–3):194. https://doi .org/10.1007/s12011-008-8194-8. PMid:18685812

  • Georgescu B, Georgescu C, Dărăban S, Bouaru A, Paşcalău S. Heavy metals acting as endocrine disrupters. Sci Pap Anim Sci Biotechno. 2011; 44(2):89–93.

  • Rolland RM. A review of chemically-induced alterations in thyroid and vitamin A status from field studies of wildlife and fish. Journal of Wildlife Diseases. 2000; 36(4):615–35. https:// doi.org/10.7589/0090-3558-36.4.615. PMid:11085423

  • Qureshi IZ, Mahmood T. Prospective role of ascorbic acid (vitamin C) in attenuating hexavalent chromium-induced functional and cellular damage in rat thyroid. Toxicology and Industrial Health. 2010; 26(6):349–59. https://doi .org/10.1177/0748233710371109. PMid:20504825

  • Mohamed HZ, Ragab IK, Ghafeer HH. A histological study on the possible protective effect of selenium against chromium-induced thyrotoxicity in adult male albino rats. Egyptian Journal of Histology. 2016; 39(1):1–11. https:// doi.org/10.1097/01.EHX.0000481747.20806.2d

  • Aboul-Fotouh GI, El-Nour A, El-Din RK, Farag E, Boughdady WAA. Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats. Egyptian Journal of Histology. 2018; 41(2):220–35. https://doi.org/10.21608/EJH.2018.13844

  • Mohamed HM, El-Twab SMA. Gallic acid attenuates chromium-induced thyroid dysfunction by modulating antioxidant status and inflammatory cytokines. Environmental Toxicology and Pharmacology. 2016; 48:225–36. https:// doi.org/10.1016/j.etap.2016.08.019. PMid:27835810

  • Hassanin KM, El-Kawi SHA, Hashem KS. The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid. International Journal of Nanomedicine. 2013; 8:1713. https://doi.org/10.2147/IJN.S42736. PMid:23658489 PMCid: PMC3646488

  • Yoshizuka M, Mori N, Hamasaki K, Tanaka I, Yokoyama M, Hara K, et al. Cadmium toxicity in the thyroid gland of pregnant rats. Experimental and Molecular Pathology. 1991; 55(1):97–104. https://doi .org/10.1016/0014-4800(91)90021-O

  • Matović V, Buha A, Ðukić-Ćosić D, Bulat Z. Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys. Food and Chemical Toxicology. 2015; 78: 130–40. https://doi.org/10.1016/j.fct.2015.02.011. PMid:25681546

  • Ambali SF, Orieji C, Abubakar WO, Shitu M, Kawu MU. Ameliorative effect of vitamin C on alterations in thyroid hormones concentrations induced by subchronic coadministration of chlorpyrifos and lead in Wistar rats. Journal of Thyroid Research. 2011; 2011. https:// doi.org/10.4061/2011/214924. PMid:21687644 PMCid: PMC3112502

  • Li Y, Zhao Y, Deng H, Chen A, Chai L. Endocrine disruption, oxidative stress and lipometabolic disturbance of Bufo gargarizans embryos exposed to hexavalent chromium. Ecotoxicology and Environmental Safety. 2018; 166:242–50. https://doi.org/10.1016/j.ecoenv.2018.09.100. PMid:30273847

  • Sun N, Wang H, Ju Z, Zhao H. Effects of chronic cadmium exposure on metamorphosis, skeletal development, and thyroid endocrine disruption in Chinese toad Bufo gargarizans tadpoles. Environmental Toxicology and Chemistry. 2018; 37(1):213–23. https://doi.org/10.1002/etc.3947. PMid:28799665

  • Lee S, Kim C, Youn H, Choi K. Thyroid hormone disrupting potentials of bisphenol A and its analogues-in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells. Toxicology in Vitro. 2017; 40:297–304. https://doi.org/10.1016/j.tiv.2017.02.004. PMid:28167136

  • Jemai H, Messaoudi I, Chaouch A, Kerkeni A. Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium. Journal of Trace Elements in Medicine and Biology. 2007; 21(4):269–73. https://doi.org/10.1016/j.jtemb.2007.08.001 PMid:17980818

  • Xiao P, Jia X, Zhong W, Jin X, Nordberg G. Restorative effects of zinc and selenium on cadmium-induced kidney oxidative damage in rats. Biomedical and Environmental Sciences. 2002; 15(1):67–74.

  • Atteia HH, Arafa MH, Prabahar K. Selenium nanoparticles prevents lead acetate-induced hypothyroidism and oxidative damage of thyroid tissues in male rats through modulation of selenoenzymes and suppression of miR-224. Biomedicine & Pharmacotherapy. 2018; 99:486–91. https://doi.org/10.1016/j.biopha.2018.01.083. PMid:29665650

  • Pagmantidis V, Méplan C, Van Schothorst EM, Keijer J, Hesketh J. Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. American Journal of Clinical Nutrition. 2008; 87(1):181–9. https://doi.org/10.1093/ajcn/87.1.181. PMid:18175754

  • Zhang J-S, Gao X-Y, Zhang L-D, Bao YP. Biological effects of a nano red elemental selenium. Biofactors. 2001; 15(1):27–38. https://doi.org/10.1002/biof.5520150103 PMid:11673642

  • El-Mehi A, Amin S. Effect of lead acetate on the thyroid gland of adult male albino rats and the possible protective role of zinc supplementation: A biochemical, histological and morphometric study. Journal of American Science. 2012; 8(7):61–71.

  • Li X, Li F, Li CF. A new insight on the role of zinc in the regulation of altered thyroid functions during lithium treatment. Minerva Endocrinologica. 2015; 42:8–14.

  • Prasad AS. Zinc is an antioxidant and anti-inflammatory agent: Its role in human health. Frontiers in Nutrition. 2014; 1:14. https://doi.org/10.3389/fnut.2014.00014. PMid:25988117 PMCid:PMC4429650

  • Cousins RJ, Hempe JM. Zinc : In Present Knowledge in Nutrition. 6th ed. Washington, DC: International Life Sciences Institute, Nutrition Foundation ; 1990. p. 251–60.

  • Sidhu P, Garg M, Dhawan D. Protective role of zinc in nickel induced hepatotoxicity in rats. ChemicoBiological Interactions. 2004; 150(2):199–209. https://doi .org/10.1016/j.cbi.2004.09.012. PMid:15535990


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  • Potential Protective Effects of Selenium and Zinc against Thyroid Toxicity Induced by Nickel in Preimplanted Wistar Albino Rats

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Authors

Salah Imane
Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules, Department of Biology of Organismes, BATNA-2 University, 5000 Batna, Algeria
Adjroud Ounassa
Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules, Department of Biology of Organismes, BATNA-2 University, 5000 Batna, Algeria
Fedala Anfal
Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules, Department of Biology of Organismes, BATNA-2 University, 5000 Batna, Algeria
Saouli Asma
Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and Biomolecules, Department of Biology of Organismes, BATNA-2 University, 5000 Batna, Algeria

Abstract


Nickel Is A Heavy Metal That May Affect The Function Of The Thyroid. The Present Study Was Undertaken To Assess The Protective Effects Of Selenium And Zinc Against Nickel-induced Thyrotoxicity In Preimplanted Wistar Albino Rats. Nickel Is Administered Alone (100 Mg/kg Body Weight) Subcutaneously Or In Combination With Selenium (0.3 Mg/kg Body Weight) Either With Zinc (20 Mg/kg Body Weight) Or Combined With Both Selenium And Zinc. All Groups Of Rats Were Injected On Day 3 Of Gestation In The Pre-implantation Period. Exposure Of Rats To Nickel Caused A Significant Decrease In Maternal Body Weight On Days 6 And 20 Of Gestation And An Increase In Absolute And Relative Thyroid Weight Compared To The Controls. Nickel Treatment Was Also Led In Decreased Plasma Triiodothyronine, Thyroxine With A Concomitant Significant Increase In Thyroid-stimulating Hormone Levels When Compared To Control. These Changes Were Confirmed By Histological Damages. However, Co-administration Of Selenium And/or Zinc To Nickel-treated Rats Restored The Hormonal And Histological Aspects. Our Findings Suggested That Selenium And Zinc Ameliorated Nickel Induced Thyroid Damage.


Keywords


Nickel, Preimplanted Rat, Thyroid Hormones, Selenium, Zinc.

References





DOI: https://doi.org/10.18311/ti%2F2019%2Fv26i1%2F24438