Toxicology International (Formerly Indian Journal of Toxicology)

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Immunomodulating Effects of Allium sativum in Renal Tissue of LPS Challenged Mice


Affiliations
1 Department of Bioscience and Biotechnology, Banasthali Vidyapith, Vanasthali Road - 304022, Rajasthan, India
     

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Allium sativum contain various medicinal properties like immunomodulatory, antitumorigenetic, antiatherosclerotic and antimicrobial. In the present study, we analyzed the impact of hydroethanol extract of Allium sativum on cytokine production in LPS challenged mice. LPS significantly induced the activation of NF-kB and also increased the levels of NO, TNF-α, IL-6, IFN-Y, PGE2 with the suppression of IL-10 production. In the results we found that Allium sativum significantly attenuated the LPS-induced phosphorylation of NF-ĸB and normalized the levels of NO, TNF-α, IL-6, IFN-Y, PGE-2 and IL-10. In summary, it was deduced that garlic may promote an anti-inflammatory effect by inhibition of NF-kB activity in the tissue.

Keywords

Allium sativum, Anti-inflammatory, Cytokines, Lipopolysaccharide (LPS), NF-kB.
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  • Immunomodulating Effects of Allium sativum in Renal Tissue of LPS Challenged Mice

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Authors

Kanchan Sharma
Department of Bioscience and Biotechnology, Banasthali Vidyapith, Vanasthali Road - 304022, Rajasthan, India
Veena Sharma
Department of Bioscience and Biotechnology, Banasthali Vidyapith, Vanasthali Road - 304022, Rajasthan, India

Abstract


Allium sativum contain various medicinal properties like immunomodulatory, antitumorigenetic, antiatherosclerotic and antimicrobial. In the present study, we analyzed the impact of hydroethanol extract of Allium sativum on cytokine production in LPS challenged mice. LPS significantly induced the activation of NF-kB and also increased the levels of NO, TNF-α, IL-6, IFN-Y, PGE2 with the suppression of IL-10 production. In the results we found that Allium sativum significantly attenuated the LPS-induced phosphorylation of NF-ĸB and normalized the levels of NO, TNF-α, IL-6, IFN-Y, PGE-2 and IL-10. In summary, it was deduced that garlic may promote an anti-inflammatory effect by inhibition of NF-kB activity in the tissue.

Keywords


Allium sativum, Anti-inflammatory, Cytokines, Lipopolysaccharide (LPS), NF-kB.

References





DOI: https://doi.org/10.18311/ti%2F2019%2Fv26i2%2F24111