Toxicology International (Formerly Indian Journal of Toxicology)

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Safety and Anti-Fatigue Activity of Ayurvedic Formulation Sramahara Mahaakaasaya - A Pre-Clinical Study


Affiliations
1 Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, New Delhi - 110058, India
2 PG Department of Dravyaguna Vigyana, National Institute of Ayurveda, Jaipur - 302002, Rajasthan, India
3 Department of Roganidana and Vikritivigyana, Uttrakhand Ayurved University, Dehradun - 248001, Uttrakhand, India
4 Assam down town University, Panikhaiti, Guwahati - 781026, Assam, India
5 Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
6 Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
     

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An experimental evaluation of anti-fatigue activity of Shramahara Mahaakashaaya (SM) and its applicability in sports medicine has been systematically evaluated. Aqueous, ethanolic and petroleum ether extracts of SM granules (200mg/kg) were studies for light-dark model test for assessment anti-anxiety effect, rota-rod test for assessment of the effect on muscle tone and muscle balance, weight loaded forced swimming test for assessment of anti-fatigue activity. The acute toxicity study of SM granules has also been evaluated as per the OECD 423. SM granules showed significant anti-fatigue activity in different experimental models and found safe up to 2000mg/kg body weight dose. The results provide an important basis for considering Shramahara Mahaakashaaya (SM) as an alternative medicine having anti-fatigue effects which can be further included in the sports medicine.


Keywords

Acute Toxicity, Anti-Anxiety, Anti-Fatigue, Shramahara Mahaakashaaya.
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  • Safety and Anti-Fatigue Activity of Ayurvedic Formulation Sramahara Mahaakaasaya - A Pre-Clinical Study

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Authors

Bidhan Mahajon
Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, New Delhi - 110058, India
A. Ramamurthy
PG Department of Dravyaguna Vigyana, National Institute of Ayurveda, Jaipur - 302002, Rajasthan, India
Rupashri Nath
Department of Roganidana and Vikritivigyana, Uttrakhand Ayurved University, Dehradun - 248001, Uttrakhand, India
Manish K. Gautam
Assam down town University, Panikhaiti, Guwahati - 781026, Assam, India
Neeladri Das
Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India
Partha Roy
Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttarakhand, India

Abstract


An experimental evaluation of anti-fatigue activity of Shramahara Mahaakashaaya (SM) and its applicability in sports medicine has been systematically evaluated. Aqueous, ethanolic and petroleum ether extracts of SM granules (200mg/kg) were studies for light-dark model test for assessment anti-anxiety effect, rota-rod test for assessment of the effect on muscle tone and muscle balance, weight loaded forced swimming test for assessment of anti-fatigue activity. The acute toxicity study of SM granules has also been evaluated as per the OECD 423. SM granules showed significant anti-fatigue activity in different experimental models and found safe up to 2000mg/kg body weight dose. The results provide an important basis for considering Shramahara Mahaakashaaya (SM) as an alternative medicine having anti-fatigue effects which can be further included in the sports medicine.


Keywords


Acute Toxicity, Anti-Anxiety, Anti-Fatigue, Shramahara Mahaakashaaya.

References